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Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA

Nucleic acids research, 2021-01, Vol.49 (2), p.713-725

2021

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Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma

Cancer cell, 2017-01, Vol.31 (1), p.50-63

2017

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p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

Nature cell biology, 2005-02, Vol.7 (2), p.165-171

2005

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Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses

Nature communications, 2021-06, Vol.12 (1), p.3622-15, Article 3622

2021

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A trapped human PPM1A–phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity

The Journal of biological chemistry, 2018-05, Vol.293 (21), p.7993-8008

2018

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Structural Basis for p300 Taz2-p53 TAD1 Binding and Modulation by Phosphorylation

Structure (London), 2009-02, Vol.17 (2), p.202-210

2009

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Targeting mutant p53-R248W reactivates WT p53 function and alters the onco-metabolic profile

Frontiers in oncology, 2023-01, Vol.12, p.1094210-1094210

2023

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Chemical Features Important for Activity in a Class of Inhibitors Targeting the Wip1 Flap Subdomain

ChemMedChem, 2018-05, Vol.13 (9), p.894-901

2018

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Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents

Proceedings of the National Academy of Sciences - PNAS, 2012-01, Vol.109 (2), p.E68-E75

2012

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Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio

Cell cycle (Georgetown, Tex.), 2012-05, Vol.11 (10), p.1883-1887

2012

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An Acetyl-Methyl Switch Drives a Conformational Change in p53

Structure (London), 2015-02, Vol.23 (2), p.322-331

2015

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UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells

DNA repair, 2011-01, Vol.10 (1), p.5-15

2011

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Acetylation of Mouse p53 at Lysine 317 Negatively Regulates p53 Apoptotic Activities after DNA Damage

Molecular and Cellular Biology, 2006-09, Vol.26 (18), p.6859-6869

2006

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p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes

The Journal of clinical investigation, 2013-12, Vol.123 (12), p.5247-5257

2013

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Crystal structure and mechanistic studies of the PPM1D serine/threonine phosphatase catalytic domain

The Journal of biological chemistry, 2024-08, Vol.300 (8), p.107561, Article 107561

2024

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Regulation of the Wip1 phosphatase and its effects on the stress response

Frontiers in bioscience (Landmark. Print), 2012-01, Vol.17 (4), p.1480

2012

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Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication

Cell cycle (Georgetown, Tex.), 2014-03, Vol.13 (6), p.1015-1029

2014

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The Area Between Exchange Curves as a Measure of Conformational Differences in Hydrogen-Deuterium Exchange Mass Spectrometry Studies

Journal of the American Society for Mass Spectrometry, 2017-05, Vol.28 (5), p.978-981

2017

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p53 N-terminal phosphorylation: a defining layer of complex regulation

Carcinogenesis (New York), 2012-08, Vol.33 (8), p.1441-1449

2012

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Variation of Tetrahydrofurans in Thyclotides Enhances Oligonucleotide Binding and Cellular Uptake of Peptide Nucleic Acids

JACS Au, 2023-07, Vol.3 (7), p.1952-1964

2023

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Alkyl-substituted N-methylaryl-N′-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase

European journal of medicinal chemistry, 2022-12, Vol.243, p.114763-114763, Article 114763

2022

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Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression

Molecular biology of the cell, 2002-08, Vol.13 (8), p.2585-2597

2002

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Genetic variants and mutations of PPM1D control the response to DNA damage

Cell cycle (Georgetown, Tex.), 2013-08, Vol.12 (16), p.2656-2664

2013

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Binding of a Third Metal Ion by the Human Phosphatases PP2Cα and Wip1 Is Required for Phosphatase Activity

Biochemistry (Easton), 2013-08, Vol.52 (34), p.5830-5843

2013

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Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange–Mass Spectrometry

Biochemistry (Easton), 2017-05, Vol.56 (21), p.2676-2689

2017

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Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA

Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma

p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses

A trapped human PPM1A–phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity

Structural Basis for p300 Taz2-p53 TAD1 Binding and Modulation by Phosphorylation

Targeting mutant p53-R248W reactivates WT p53 function and alters the onco-metabolic profile

Chemical Features Important for Activity in a Class of Inhibitors Targeting the Wip1 Flap Subdomain

Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents

Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio

An Acetyl-Methyl Switch Drives a Conformational Change in p53

UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells

Acetylation of Mouse p53 at Lysine 317 Negatively Regulates p53 Apoptotic Activities after DNA Damage

p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes

Crystal structure and mechanistic studies of the PPM1D serine/threonine phosphatase catalytic domain

Regulation of the Wip1 phosphatase and its effects on the stress response

Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication

The Area Between Exchange Curves as a Measure of Conformational Differences in Hydrogen-Deuterium Exchange Mass Spectrometry Studies

p53 N-terminal phosphorylation: a defining layer of complex regulation

Variation of Tetrahydrofurans in Thyclotides Enhances Oligonucleotide Binding and Cellular Uptake of Peptide Nucleic Acids

Alkyl-substituted N-methylaryl-N′-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase

Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression

Genetic variants and mutations of PPM1D control the response to DNA damage

Binding of a Third Metal Ion by the Human Phosphatases PP2Cα and Wip1 Is Required for Phosphatase Activity

Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange–Mass Spectrometry

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