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New Mechanism of Gemcitabine and Its Phosphates: DNA Polymerization Disruption via 3′–5′ Exonuclease Inhibition

Biochemistry (Easton), 2020-11, Vol.59 (45), p.4344-4352

2020

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Crystallographic and molecular-modeling studies of lipase B from Candida antarctica reveal a stereospecificity pocket for secondary alcohols

Biochemistry (Easton), 1995-12, Vol.34 (51), p.16838-16851

1995

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Why Are Lopinavir and Ritonavir Effective against the Newly Emerged Coronavirus 2019? Atomistic Insights into the Inhibitory Mechanisms

Biochemistry (Easton), 2020-05, Vol.59 (18), p.1769-1779

2020

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Crystal Structure of the IMP-1 Metallo β-Lactamase from Pseudomonas aeruginosa and Its Complex with a Mercaptocarboxylate Inhibitor: Binding Determinants of a Potent, Broad-Spectrum Inhibitor

Biochemistry (Easton), 2000-04, Vol.39 (15), p.4288-4298

2000

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Tuning of Peroxiredoxin Catalysis for Various Physiological Roles

Biochemistry (Easton), 2014-12, Vol.53 (49), p.7693-7705

2014

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Inhibition of Transforming Growth Factor-β Signaling by Low Molecular Weight Compounds Interfering with ATP- or Substrate-Binding Sites of the TGFβ Type I Receptor Kinase

Biochemistry (Easton), 2002-09, Vol.41 (36), p.11000-11007

2002

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Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues

Biochemistry (Easton), 2019-02, Vol.58 (5), p.391-400

2019

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Structural and Functional Analyses of Inhibition of Human Dihydroorotate Dehydrogenase by Antiviral Furocoumavirin

Biochemistry (Easton), 2024-05, Vol.63 (10), p.1241-1245

2024

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Structurally Designed trans-2-Phenylcyclopropylamine Derivatives Potently Inhibit Histone Demethylase LSD1/KDM1

Biochemistry (Easton), 2010-08, Vol.49 (30), p.6494-6503

2010

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Stimulation of Topoisomerase II-Mediated DNA Cleavage by Three DNA-Intercalating Plant Alkaloids: Cryptolepine, Matadine, and Serpentine

Biochemistry (Easton), 1999-06, Vol.38 (24), p.7719-7726

1999

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Specificity Distorted: Chemical Induction of Biological Paracatalysis

Biochemistry (Easton), 2020-09, Vol.59 (38), p.3517-3522

2020

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Novel Mechanistic Class of Fatty Acid Amide Hydrolase Inhibitors with Remarkable Selectivity

Biochemistry (Easton), 2007-11, Vol.46 (45), p.13019-13030

2007

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Irreversible Inhibition of the Mycobacterium tuberculosis β-Lactamase by Clavulanate

Biochemistry (Easton), 2007-10, Vol.46 (43), p.11998-12004

2007

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Alzheimer's Amyloid Precursor Protein α-Secretase Is Inhibited by Hydroxamic Acid-Based Zinc Metalloprotease Inhibitors: Similarities to the Angiotensin Converting Enzyme Secretase

Biochemistry (Easton), 1998-02, Vol.37 (6), p.1680-1685

1998

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Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer’s Disease

Biochemistry (Easton), 2020-07, Vol.59 (28), p.2585-2591

2020

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Structural Dissection of Helianthamide Reveals the Basis of Its Potent Inhibition of Human Pancreatic α‑Amylase

Biochemistry (Easton), 2018-09, Vol.57 (37), p.5384-5387

2018

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Synthetic Triterpenoid Inhibition of Human Ghrelin O‑Acyltransferase: The Involvement of a Functionally Required Cysteine Provides Mechanistic Insight into Ghrelin Acylation

Biochemistry (Easton), 2017-02, Vol.56 (7), p.919-931

2017

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Structural and Functional Studies of Bacterial Enolase, a Potential Target against Gram-Negative Pathogens

Biochemistry (Easton), 2019-03, Vol.58 (9), p.1188-1197

2019

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Identification of Inhibitors of the dNTP Triphosphohydrolase SAMHD1 Using a Novel and Direct High-Throughput Assay

Biochemistry (Easton), 2018-11, Vol.57 (47), p.6624-6636

2018

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Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors

Biochemistry (Easton), 2018-11, Vol.57 (47), p.6604-6614

2018

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Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase

Biochemistry (Easton), 2024-03, Vol.63 (6), p.788-796

2024

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Transition State Analogue Inhibitors of 5′-Deoxyadenosine/5′-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis

Biochemistry (Easton), 2017-09, Vol.56 (38), p.5090-5098

2017

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Targeting a Cryptic Allosteric Site for Selective Inhibition of the Oncogenic Protein Tyrosine Phosphatase Shp2

Biochemistry (Easton), 2015-01, Vol.54 (2), p.497-504

2015

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Novel Noncompetitive Type Three Secretion System ATPase Inhibitors Shut Down Shigella Effector Secretion

Biochemistry (Easton), 2020-07, Vol.59 (28), p.2667-2678

2020

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Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production

Biochemistry (Easton), 2016-08, Vol.55 (31), p.4356-4365

2016

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New Mechanism of Gemcitabine and Its Phosphates: DNA Polymerization Disruption via 3′–5′ Exonuclease Inhibition

Crystallographic and molecular-modeling studies of lipase B from Candida antarctica reveal a stereospecificity pocket for secondary alcohols

Why Are Lopinavir and Ritonavir Effective against the Newly Emerged Coronavirus 2019? Atomistic Insights into the Inhibitory Mechanisms

Crystal Structure of the IMP-1 Metallo β-Lactamase from Pseudomonas aeruginosa and Its Complex with a Mercaptocarboxylate Inhibitor: Binding Determinants of a Potent, Broad-Spectrum Inhibitor

Tuning of Peroxiredoxin Catalysis for Various Physiological Roles

Inhibition of Transforming Growth Factor-β Signaling by Low Molecular Weight Compounds Interfering with ATP- or Substrate-Binding Sites of the TGFβ Type I Receptor Kinase

Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues

Structural and Functional Analyses of Inhibition of Human Dihydroorotate Dehydrogenase by Antiviral Furocoumavirin

Structurally Designed trans-2-Phenylcyclopropylamine Derivatives Potently Inhibit Histone Demethylase LSD1/KDM1

Stimulation of Topoisomerase II-Mediated DNA Cleavage by Three DNA-Intercalating Plant Alkaloids: Cryptolepine, Matadine, and Serpentine

Specificity Distorted: Chemical Induction of Biological Paracatalysis

Novel Mechanistic Class of Fatty Acid Amide Hydrolase Inhibitors with Remarkable Selectivity

Irreversible Inhibition of the Mycobacterium tuberculosis β-Lactamase by Clavulanate

Alzheimer's Amyloid Precursor Protein α-Secretase Is Inhibited by Hydroxamic Acid-Based Zinc Metalloprotease Inhibitors: Similarities to the Angiotensin Converting Enzyme Secretase

Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer’s Disease

Structural Dissection of Helianthamide Reveals the Basis of Its Potent Inhibition of Human Pancreatic α‑Amylase

Synthetic Triterpenoid Inhibition of Human Ghrelin O‑Acyltransferase: The Involvement of a Functionally Required Cysteine Provides Mechanistic Insight into Ghrelin Acylation

Structural and Functional Studies of Bacterial Enolase, a Potential Target against Gram-Negative Pathogens

Identification of Inhibitors of the dNTP Triphosphohydrolase SAMHD1 Using a Novel and Direct High-Throughput Assay

Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors

Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase

Transition State Analogue Inhibitors of 5′-Deoxyadenosine/5′-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis

Targeting a Cryptic Allosteric Site for Selective Inhibition of the Oncogenic Protein Tyrosine Phosphatase Shp2

Novel Noncompetitive Type Three Secretion System ATPase Inhibitors Shut Down Shigella Effector Secretion

Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production

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