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Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing

Clinical cancer research, 2022-10, Vol.28 (20), p.4551-4564

2022

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LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML

Blood, 2018-04, Vol.131 (15), p.1730-1742

2018

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Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models

The Prostate, 2024-07, Vol.84 (10), p.909-921

2024

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Bomedemstat as an investigative treatment for myeloproliferative neoplasms

Expert opinion on investigational drugs, 2023-10, Vol.32 (10), p.879-886

2023

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Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition

Cancer discovery, 2020-10, Vol.10 (10), p.1500-1513

2020

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Antimalarial iron chelator, FBS0701, shows asexual and gametocyte Plasmodium falciparum activity and single oral dose cure in a murine malaria model

PloS one, 2012-05, Vol.7 (5), p.e37171

2012

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LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone

HemaSphere, 2018-06, Vol.2 (3), p.e54-n/a

2018

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Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes

Wellcome open research, 2023, Vol.8, p.146-146

2023

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A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with marfan and loeys-dietz syndrome

American journal of medical genetics. Part A, 2013-08, Vol.161A (8), p.2040-2046

2013

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A phase 1 dose-escalation study: safety, tolerability, and pharmacokinetics of FBS0701, a novel oral iron chelator for the treatment of transfusional iron overload

Haematologica (Roma), 2011-04, Vol.96 (4), p.521-525

2011

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Cardiac R2 values are independent of the image analysis approach employed

Magnetic resonance in medicine, 2014-08, Vol.72 (2), p.485-491

2014

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Response to "De novo mutation of the TGFB3 latency-associated peptide domain in a patient with overgrowth and Loeys-Dietz syndrome features"

American journal of medical genetics. Part A, 2014-08, Vol.164A (8), p.2144-2145

Rienhoff Jr, Hugh Young

2014

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Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss

BMC medical genetics, 2020-02, Vol.21 (1), p.35-35, Article 35

2020

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LSD1 Inhibition with IMG7289 (bomedemstat) Rebalances Megakaryopoiesis and Erythropoiesis in a Patient with MPN/MDS with Refractory Anemia with Ringed Sideroblast and Marked Thrombocytosis with JAK2 and SF3B1 Mutations

Blood, 2020-11, Vol.136 (Supplement 1), p.23-24

2020

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A Phase 2 Study of the LSD1 Inhibitor Img-7289 (bomedemstat) for the Treatment of Essential Thrombocythemia (ET)

Blood, 2021-11, Vol.138 (Supplement 1), p.386-386

2021

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Reflections on my daughter's DNA

Applied & translational genomics, 2016-03, Vol.8, p.45-48

Rienhoff, Hugh Young

2016

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Genomewide Association Studies and Assessment of Risk of Disease

The New England journal of medicine, 2010-11, Vol.363 (21), p.2076-2077

2010

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Are cardiac R2 values dependent on the image analysis approach employed?

Journal of cardiovascular magnetic resonance, 2013-01, Vol.15 (Suppl 1), p.P76-P76, Article P76

2013

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Iron-overload-related disease in HFE hereditary hemochromatosis

The New England journal of medicine, 2008-05, Vol.358 (21), p.2294; author reply 2294-2294; author reply 2295

Rienhoff, Jr, Hugh Young

2008

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Iron-Overload–Related Disease in HFE Hereditary Hemochromatosis

The New England journal of medicine, 2008-05, Vol.358 (21), p.2293-2295

2008

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Single oral dose cure of lethal P. yoelii with a new iron chelator in human clinical trials for iron overload

Malaria journal, 2010-10, Vol.9 (S2), p.P54-P54, Article P54

2010

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An Enhanced Sensitivity DNA Sequencing Protocol for the Detection in AML of Measurable Residual Disease (MRD) Applicable for All Mutations

Blood, 2018-11, Vol.132 (Supplement 1), p.5279-5279

2018

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LSD1 Inhibition Synergizes with Venetoclax in Acute Myeloid Leukemia By Targeting Cellular Metabolism

Blood, 2023-11, Vol.142 (Supplement 1), p.4156-4156

2023

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Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse

American journal of physiology: endocrinology and metabolism, 2010-06, Vol.298 (6), p.E1236-E1243

2010

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Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing

LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML

Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models

Bomedemstat as an investigative treatment for myeloproliferative neoplasms

Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia

Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition

Antimalarial iron chelator, FBS0701, shows asexual and gametocyte Plasmodium falciparum activity and single oral dose cure in a murine malaria model

LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone

Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes

A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with marfan and loeys-dietz syndrome

A phase 1 dose-escalation study: safety, tolerability, and pharmacokinetics of FBS0701, a novel oral iron chelator for the treatment of transfusional iron overload

Cardiac R2 values are independent of the image analysis approach employed

Response to "De novo mutation of the TGFB3 latency-associated peptide domain in a patient with overgrowth and Loeys-Dietz syndrome features"

Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss

LSD1 Inhibition with IMG7289 (bomedemstat) Rebalances Megakaryopoiesis and Erythropoiesis in a Patient with MPN/MDS with Refractory Anemia with Ringed Sideroblast and Marked Thrombocytosis with JAK2 and SF3B1 Mutations

A Phase 2 Study of the LSD1 Inhibitor Img-7289 (bomedemstat) for the Treatment of Essential Thrombocythemia (ET)

Reflections on my daughter's DNA

Genomewide Association Studies and Assessment of Risk of Disease

Are cardiac R2 values dependent on the image analysis approach employed?

Iron-overload-related disease in HFE hereditary hemochromatosis

Iron-Overload–Related Disease in HFE Hereditary Hemochromatosis

Single oral dose cure of lethal P. yoelii with a new iron chelator in human clinical trials for iron overload

An Enhanced Sensitivity DNA Sequencing Protocol for the Detection in AML of Measurable Residual Disease (MRD) Applicable for All Mutations

LSD1 Inhibition Synergizes with Venetoclax in Acute Myeloid Leukemia By Targeting Cellular Metabolism

Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse

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