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Maternal treatment with oral intestinal alkaline phosphatase mitigates high fat diet-induced cognitive disorders in offspring mice

Behavioural brain research, 2020-08, Vol.392, p.112701-112701, Article 112701

2020

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673. Novel Delayed-Release Formulation of an Oral β-Lactamase Prevents Gut Microbiome Damage and Attenuates Antibiotic Resistance Caused by Oral Amoxicillin/Clavulanate without Interfering with Amoxicillin Systemic Absorption in Dogs

Open forum infectious diseases, 2019-10, Vol.6 (Supplement_2), p.S307-S307

2019

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1140 – Syn-007, an Oral Beta-Lactamase Prevents Gut Microbime Dysbiosis Caused by Oral Amoxicillin and Oral Amoxicillin/Clavulanate Without Affecting Amoxicillin Systemic Absorption in Dogs

Gastroenterology (New York, N.Y. 1943), 2019-05, Vol.156 (6), p.S-241-S-242

2019

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620. Oral β-Lactamase Therapies Prevent Microbiome Damage and Attenuate Antibiotic Resistance From IV and Oral Antibiotics in Large Animal Models of Antibiotic-Mediated Gut Dysbiosis

Open forum infectious diseases, 2018-11, Vol.5 (suppl_1), p.S226-S226

2018

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Sa1839 - Orally Delivered Beta-Lactamase Prevents Gut Microbiome Dysbiosis Caused by IV and Oral Antibiotics and Mitigates Propagation of Antibiotic Resistance in Porcine and Canine Models

Gastroenterology (New York, N.Y. 1943), 2018-05, Vol.154 (6), p.S-415-S-415

2018

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Gut Antibiotic Inactivation by Β-Lactamases Is Intended to Prevent Microbiome Damage and Attenuate Antibiotic Resistance in Large Animal Models

Open forum infectious diseases, 2017-10, Vol.4 (suppl_1), p.S232-S233

2017

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SYN-006, a Novel Carbapenemase, Intended to Protect the Gut Microbiome from Antibiotic-Mediated Damage May Also Reduce Propagation of Carbapenem-Resistant Pathogens

Open forum infectious diseases, 2017-10, Vol.4 (suppl_1), p.S231-S232

2017

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An Orally Delivered Beta-Lactamase Protects the Gut Microbiome from Antibiotic-Mediated Damage and Mitigates the Propagation of Antibiotic-Resistance Genes in a Porcine Dysbiosis Model

Gastroenterology (New York, N.Y. 1943), 2017-04, Vol.152 (5), p.S1305-S1306

2017

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332g - An Orally Delivered Beta-Lactamase Protects the Gut Microbiome from Antibiotic-Mediated Damage and Mitigates the Propagation of Antibiotic-Resistance Genes in a Porcine Dysbiosis Model

Gastroenterology (New York, N.Y. 1943), 2017-04, Vol.152 (5), p.S1305-S1306

2017

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Clinical-Stage, Oral β-Lactamase Enzyme to Prevent Clostridium difficile Infection Triggered by Antibiotic-Mediated Gut Microbiome Disruption

Open forum infectious diseases, 2016-12, Vol.3 (suppl_1)

2016

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Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles

The Journal of clinical investigation, 2015-04, Vol.125 (4), p.1471-1484

2015

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A Crucial Role for Caspase 1 in Thrombo-Inflammatory Microparticle Release

Blood, 2014-12, Vol.124 (21), p.2806-2806

2014

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Abstract 70: P2X7-Induced Thiol-Disulfide Exchange is Critical for the Coupling of Coagulation and Inflammation

Arteriosclerosis, thrombosis, and vascular biology, 2013-05, Vol.33 (suppl_1)

2013

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Inflammation, Obesity, and Thrombosis

Blood, 2012-11, Vol.120 (21), p.SCI-45-SCI-45

2012

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Thrombosis and Inflammation Are Coupled by a Common Thioredoxin Reductase Pathway Downstream of the P2×7 Receptor

Blood, 2012-11, Vol.120 (21), p.2218-2218

2012

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Infrared fluorescence for vascular barrier breach in vivo--a novel method for quantitation of albumin efflux

Thrombosis and haemostasis, 2012-11, Vol.108 (5), p.981-991

2012

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Protease-Activated Receptor 4 (PAR4) Plays a Critical Role in Fetal Loss and Peripheral Thrombosis in a Mouse Model of Thrombophilia

Blood, 2011-11, Vol.118 (21), p.373-373

2011

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Tissue factor-PAR2 signaling promotes diet-induced obesity and adipose inflammation

Nature medicine, 2011-10, Vol.17 (11), p.1490-1497

2011

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P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice

The Journal of clinical investigation, 2011-07, Vol.121 (7), p.2932-2944

2011

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P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice

The Journal of clinical investigation, 2011-07, Vol.121 (7), p.2932

2011

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Novel Infrared Fluorescence Methodology Defines An Essential Role for Endothelial Protein C Receptor (EPCR) for Protection Against Vascular Leakage In Inflammation

Blood, 2010-11, Vol.116 (21), p.653-653

2010

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P2×7 Signaling Triggers Tissue Factor Activation and Protein Disulfide Isomerase-Dependent Release of TF+ Microparticles In Thrombosis

Blood, 2010-11, Vol.116 (21), p.344-344

2010

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Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

Blood, 2009-11, Vol.114 (20), p.4562-4565

2009

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Vascular and dendritic cell coagulation signaling in sepsis progression

Journal of thrombosis and haemostasis, 2009-07, Vol.7 (Suppl 1), p.118-121

2009

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Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

Blood, 2009-03, Vol.113 (12), p.2859-2866

2009

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Maternal treatment with oral intestinal alkaline phosphatase mitigates high fat diet-induced cognitive disorders in offspring mice

673. Novel Delayed-Release Formulation of an Oral β-Lactamase Prevents Gut Microbiome Damage and Attenuates Antibiotic Resistance Caused by Oral Amoxicillin/Clavulanate without Interfering with Amoxicillin Systemic Absorption in Dogs

1140 – Syn-007, an Oral Beta-Lactamase Prevents Gut Microbime Dysbiosis Caused by Oral Amoxicillin and Oral Amoxicillin/Clavulanate Without Affecting Amoxicillin Systemic Absorption in Dogs

620. Oral β-Lactamase Therapies Prevent Microbiome Damage and Attenuate Antibiotic Resistance From IV and Oral Antibiotics in Large Animal Models of Antibiotic-Mediated Gut Dysbiosis

Sa1839 - Orally Delivered Beta-Lactamase Prevents Gut Microbiome Dysbiosis Caused by IV and Oral Antibiotics and Mitigates Propagation of Antibiotic Resistance in Porcine and Canine Models

Gut Antibiotic Inactivation by Β-Lactamases Is Intended to Prevent Microbiome Damage and Attenuate Antibiotic Resistance in Large Animal Models

SYN-006, a Novel Carbapenemase, Intended to Protect the Gut Microbiome from Antibiotic-Mediated Damage May Also Reduce Propagation of Carbapenem-Resistant Pathogens

An Orally Delivered Beta-Lactamase Protects the Gut Microbiome from Antibiotic-Mediated Damage and Mitigates the Propagation of Antibiotic-Resistance Genes in a Porcine Dysbiosis Model

332g - An Orally Delivered Beta-Lactamase Protects the Gut Microbiome from Antibiotic-Mediated Damage and Mitigates the Propagation of Antibiotic-Resistance Genes in a Porcine Dysbiosis Model

Clinical-Stage, Oral β-Lactamase Enzyme to Prevent Clostridium difficile Infection Triggered by Antibiotic-Mediated Gut Microbiome Disruption

Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles

A Crucial Role for Caspase 1 in Thrombo-Inflammatory Microparticle Release

Abstract 70: P2X7-Induced Thiol-Disulfide Exchange is Critical for the Coupling of Coagulation and Inflammation

Inflammation, Obesity, and Thrombosis

Thrombosis and Inflammation Are Coupled by a Common Thioredoxin Reductase Pathway Downstream of the P2×7 Receptor

Infrared fluorescence for vascular barrier breach in vivo--a novel method for quantitation of albumin efflux

Protease-Activated Receptor 4 (PAR4) Plays a Critical Role in Fetal Loss and Peripheral Thrombosis in a Mouse Model of Thrombophilia

Tissue factor-PAR2 signaling promotes diet-induced obesity and adipose inflammation

P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice

P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice

Novel Infrared Fluorescence Methodology Defines An Essential Role for Endothelial Protein C Receptor (EPCR) for Protection Against Vascular Leakage In Inflammation

P2×7 Signaling Triggers Tissue Factor Activation and Protein Disulfide Isomerase-Dependent Release of TF+ Microparticles In Thrombosis

Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

Vascular and dendritic cell coagulation signaling in sepsis progression

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

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