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ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses

The Journal of immunology (1950), 2018-03, Vol.200 (6), p.2025-2037

2018

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29 Immune modulation and baseline biomarker correlation with clinical benefit following treatment with COM701+nivolumab+/-BMS-986207 in patients with platinum resistant ovarian cancer

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A32-A34

2023

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Discovery and Validation of Novel Peptide Agonists for G-protein-coupled Receptors

The Journal of biological chemistry, 2008-12, Vol.283 (50), p.34643-34649

2008

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252 Novel DNAM-1 axis member, PVRIG, is potentially a dominant checkpoint involved in stem-like memory T cells – dendritic cell interaction

Journal for immunotherapy of cancer, 2021-11, Vol.9 (Suppl 2), p.A272-A273

2021

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Peptides modulating conformational changes in secreted chaperones: From in silico design to preclinical proof of concept

Proceedings of the National Academy of Sciences - PNAS, 2009-08, Vol.106 (33), p.13797-13801

2009

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A Novel Recombinant Soluble Splice Variant of Met Is a Potent Antagonist of the Hepatocyte Growth Factor/Scatter Factor-Met Pathway

Clinical cancer research, 2008-07, Vol.14 (14), p.4612-4621

2008

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Systematic antigenic profiling of hematopoietic antigens on ovarian carcinoma cells identifies membrane proteins for targeted therapy development

American journal of obstetrics and gynecology, 2009-08, Vol.201 (2), p.196.e1-196.e7

2009

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PVRIG is Expressed on Stem-Like T Cells in Dendritic Cell–Rich Niches in Tumors and Its Blockade May Induce Immune Infiltration in Non-Inflamed Tumors

Cancer immunology research, 2024-07, Vol.12 (7), p.876-890

2024

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Abstract 584: From code to cure: Computational discovery of novel immune checkpoints

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.584-584

2017

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Abstract 2778: Discovery and preclinical characterization of BAY 1905254 a novel immune checkpoint inhibitor for cancer immunotherapy targeting the immunoglobulin-like domain containing receptor 2 (ILDR2)

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.2778-2778

2018

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Abstract 4292: Gene model correction for PVRIG and TIGIT in single cell sequencing data enables accurate detection and study of its functional relevance

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.4292-4292

2023

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Abstract 7533: PVRIG is uniquely expressed in tumor dendritic cells-rich niches on stem-like memory T cells and its blockade may induce immune infiltration and activation in non-inflamed tumors

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.7533-7533

2024

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Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2)

Cancer immunology research, 2020-07, Vol.8 (7), p.895-911

2020

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Abstract 581: Discovery and development of COM701, a therapeutic antibody targeting the novel immune checkpoint PVRIG

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.581-581

2017

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Abstract 5027: Identification of novel immune checkpoints as potential targets for cancer immunotherapy

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.5027-5027

2014

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Abstract B291: Identification of novel immune checkpoints and their implementation as mAb targets for cancer immunotherapy

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.B291-B291

2013

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Large-scale protein annotation through gene ontology

Genome research, 2002-05, Vol.12 (5), p.785-794

2002

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Blockage of CGEN-928 Expression Down-Regulates AKT Signaling Pathway and Inhibits Multiple Myeloma (MM) Cell Proliferation

Blood, 2011-11, Vol.118 (21), p.5102-5102

2011

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Multiple Myeloma (MM) Highly Expresses CGEN-928 and the Anti-CGEN-928 TM21 Antibody Markedly Inhibits the Growth of MM Cells and Enhances the Anti-Myeloma Effects of Dexamethasone, Melphalan and Bortezomib

Blood, 2010-11, Vol.116 (21), p.4067-4067

2010

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Activation of Relaxin-Related Receptors by Short, Linear Peptides Derived from a Collagen-Containing Precursor

Annals of the New York Academy of Sciences, 2009-04, Vol.1160 (1), p.78-86

2009

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Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific

Cellular and molecular neurobiology, 2000-06, Vol.20 (3), p.305-317

2000

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cGMP Formation in Rat Atrial Slices Is Ligand and Endothelin Receptor Subtype Specific

Circulation research, 1996-03, Vol.78 (3), p.424-430

1996

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Identification of novel immune checkpoints as targets for cancer immunotherapy

Journal for immunotherapy of cancer, 2013-11, Vol.1 (S1), p.P135-P135, Article P135

2013

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Arachidonic acid and lipoxygenase products stimulate protein kinase C beta mRNA levels in pituitary alpha T3-1 cell line: role in gonadotropin-releasing hormone action

Biochemical journal, 1996-06, Vol.316 ( Pt 2) (2), p.667-670

1996

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Arachidonic acid and lipoxygenase products stimulate gonadotropin alpha-subunit mRNA levels in pituitary alpha T3-1 cell line: role in gonadotropin releasing hormone action

Biochemistry (Easton), 1994-11, Vol.33 (43), p.12795-12799

1994

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ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses

29 Immune modulation and baseline biomarker correlation with clinical benefit following treatment with COM701+nivolumab+/-BMS-986207 in patients with platinum resistant ovarian cancer

Discovery and Validation of Novel Peptide Agonists for G-protein-coupled Receptors

252 Novel DNAM-1 axis member, PVRIG, is potentially a dominant checkpoint involved in stem-like memory T cells – dendritic cell interaction

Peptides modulating conformational changes in secreted chaperones: From in silico design to preclinical proof of concept

A Novel Recombinant Soluble Splice Variant of Met Is a Potent Antagonist of the Hepatocyte Growth Factor/Scatter Factor-Met Pathway

Systematic antigenic profiling of hematopoietic antigens on ovarian carcinoma cells identifies membrane proteins for targeted therapy development

PVRIG is Expressed on Stem-Like T Cells in Dendritic Cell–Rich Niches in Tumors and Its Blockade May Induce Immune Infiltration in Non-Inflamed Tumors

Abstract 584: From code to cure: Computational discovery of novel immune checkpoints

Abstract 2778: Discovery and preclinical characterization of BAY 1905254 a novel immune checkpoint inhibitor for cancer immunotherapy targeting the immunoglobulin-like domain containing receptor 2 (ILDR2)

Abstract 4292: Gene model correction for PVRIG and TIGIT in single cell sequencing data enables accurate detection and study of its functional relevance

Abstract 7533: PVRIG is uniquely expressed in tumor dendritic cells-rich niches on stem-like memory T cells and its blockade may induce immune infiltration and activation in non-inflamed tumors

Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2)

Abstract 581: Discovery and development of COM701, a therapeutic antibody targeting the novel immune checkpoint PVRIG

Abstract 5027: Identification of novel immune checkpoints as potential targets for cancer immunotherapy

Abstract B291: Identification of novel immune checkpoints and their implementation as mAb targets for cancer immunotherapy

Large-scale protein annotation through gene ontology

Blockage of CGEN-928 Expression Down-Regulates AKT Signaling Pathway and Inhibits Multiple Myeloma (MM) Cell Proliferation

Multiple Myeloma (MM) Highly Expresses CGEN-928 and the Anti-CGEN-928 TM21 Antibody Markedly Inhibits the Growth of MM Cells and Enhances the Anti-Myeloma Effects of Dexamethasone, Melphalan and Bortezomib

Activation of Relaxin-Related Receptors by Short, Linear Peptides Derived from a Collagen-Containing Precursor

Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific

cGMP Formation in Rat Atrial Slices Is Ligand and Endothelin Receptor Subtype Specific

Identification of novel immune checkpoints as targets for cancer immunotherapy

Arachidonic acid and lipoxygenase products stimulate protein kinase C beta mRNA levels in pituitary alpha T3-1 cell line: role in gonadotropin-releasing hormone action

Arachidonic acid and lipoxygenase products stimulate gonadotropin alpha-subunit mRNA levels in pituitary alpha T3-1 cell line: role in gonadotropin releasing hormone action

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