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Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease

Nature communications, 2020-10, Vol.11 (1), p.5370-5370, Article 5370

2020

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Potential function for the Huntingtin protein as a scaffold for selective autophagy

Proceedings of the National Academy of Sciences - PNAS, 2014-11, Vol.111 (47), p.16889-16894

2014

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PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo

Neuron (Cambridge, Mass.), 2016-05, Vol.90 (3), p.507-520

2016

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Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

The Journal of neuroscience, 2008-11, Vol.28 (45), p.11500-11510

2008

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Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice

Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (9), p.3528-3533

2012

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Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

Human molecular genetics, 2008-12, Vol.17 (23), p.3767-3775

2008

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Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease

Nature communications, 2023-03, Vol.14 (1), p.1194-1194, Article 1194

2023

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Serine 421 regulates mutant huntingtin toxicity and clearance in mice

The Journal of clinical investigation, 2016-09, Vol.126 (9), p.3585-3597

2016

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A cause for childhood ataxia

eLife, 2016-03, Vol.5

Steffan, Joan S

2016

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The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis

Human molecular genetics, 2007-01, Vol.16 (1), p.61-77

2007

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APOE4 dysregulates autophagy in cultured cells

Autophagy reports, 2022-01, Vol.1 (1), p.29-33

2022

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Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor, Ameliorates Motor Deficits in a Mouse Model of Huntington's Disease

Proceedings of the National Academy of Sciences - PNAS, 2003-02, Vol.100 (4), p.2041-2046

2003

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The Huntington's Disease Protein Interacts with p53 and CREB-Binding Protein and Represses Transcription

Proceedings of the National Academy of Sciences - PNAS, 2000-06, Vol.97 (12), p.6763-6768

2000

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Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease

Matrix biology plus, 2021-12, Vol.12, p.100089-100089, Article 100089

2021

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Normal-Repeat-Length Polyglutamine Peptides Accelerate Aggregation Nucleation and Cytotoxicity of Expanded Polyglutamine Proteins

Proceedings of the National Academy of Sciences - PNAS, 2006-09, Vol.103 (39), p.14367-14372

2006

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Serine residues 13 and 16 are key modulators of mutant huntingtin induced toxicity in Drosophila

Experimental neurology, 2021-04, Vol.338, p.113463, Article 113463

2021

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Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins

Journal of cell science, 2022-01, Vol.135 (2)

2022

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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

The Journal of cell biology, 2009-12, Vol.187 (7), p.1083-1099

2009

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Diminished LC3-Associated Phagocytosis by Huntington's Disease Striatal Astrocytes

Journal of Huntington's disease, 2022-01, Vol.11 (1), p.25

2022

Volltextzugriff (PDF)

Autophagy researchers

Autophagy, 2014-02, Vol.10 (2), p.188-191

2014

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Histone Deacetylase Inhibitors Reduce Polyglutamine Toxicity

Proceedings of the National Academy of Sciences - PNAS, 2001-12, Vol.98 (26), p.15179-15184

2001

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Human Neural Progenitor Transplantation Rescues Behavior and Reduces α‐Synuclein in a Transgenic Model of Dementia with Lewy Bodies

Stem cells translational medicine, 2017-06, Vol.6 (6), p.1477-1490

2017

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A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila

Nature genetics, 2002-04, Vol.30 (4), p.367-376

2002

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Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice

Journal of Huntington's disease, 2012, Vol.1 (1), p.71

2012

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Phosphorylation of Threonine 3

The Journal of biological chemistry, 2009-10, Vol.284 (43), p.29427-29436

2009

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Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease

Potential function for the Huntingtin protein as a scaffold for selective autophagy

PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease

Serine 421 regulates mutant huntingtin toxicity and clearance in mice

A cause for childhood ataxia

The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis

APOE4 dysregulates autophagy in cultured cells

Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor, Ameliorates Motor Deficits in a Mouse Model of Huntington's Disease

The Huntington's Disease Protein Interacts with p53 and CREB-Binding Protein and Represses Transcription

Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease

Normal-Repeat-Length Polyglutamine Peptides Accelerate Aggregation Nucleation and Cytotoxicity of Expanded Polyglutamine Proteins

Serine residues 13 and 16 are key modulators of mutant huntingtin induced toxicity in Drosophila

Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

Diminished LC3-Associated Phagocytosis by Huntington's Disease Striatal Astrocytes

Autophagy researchers

Histone Deacetylase Inhibitors Reduce Polyglutamine Toxicity

Human Neural Progenitor Transplantation Rescues Behavior and Reduces α‐Synuclein in a Transgenic Model of Dementia with Lewy Bodies

A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila

Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice

Phosphorylation of Threonine 3

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