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Cell-specific AHR-driven differential gene expression in the mouse liver cell following acute TCDD exposure

BMC genomics, 2024-08, Vol.25 (1), p.809-13, Article 809

2024

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Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver

International journal of molecular sciences, 2022-01, Vol.23 (3), p.1558

2022

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Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver

Scientific reports, 2023-03, Vol.13 (1), p.4138-4138, Article 4138

2023

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice

Scientific reports, 2020-09, Vol.10 (1), p.14831, Article 14831

2020

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A Physiologically Based Pharmacokinetic (PBPK) Modeling Framework for Mixtures of Dioxin-like Compounds

Toxics (Basel), 2022-11, Vol.10 (11), p.700

2022

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Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice

PloS one, 2017-09, Vol.12 (9), p.e0184842

2017

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Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis

Toxicological sciences, 2016-12, Vol.154 (2), p.253-266

2016

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Disruption of canonical AHR-mediated induction of hepatocyte PKM2 expression compromises antioxidant defenses and increases TCDD-induced hepatotoxicity

Redox biology, 2024-11, Vol.77, p.103405, Article 103405

2024

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Identification and Assessment of Endocrine Disruptors: Limitations of in Vivo and in Vitro Assays

Environmental health perspectives, 1998-04, Vol.106, p.577

Zacharewski, Tim

1998

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Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice

Toxicological sciences, 2023-01, Vol.191 (1), p.135-148

2023

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Benchmarking of a Bayesian single cell RNAseq differential gene expression test for dose-response study designs

Nucleic acids research, 2022-05, Vol.50 (8), p.e48-e48

2022

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In Vitro Bioassays for Assessing Estrogenic Substances

Environmental science & technology, 1997-03, Vol.31 (3), p.613-623

Zacharewski, T

1997

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Analysis of Cell–Cell Communication by Single-Nuclei RNA Sequencing Identifies AHR-Mediated Induction of NRG-ERBB Signaling

Receptors, 2023-05, Vol.2 (2), p.148-159

2023

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RNA-Seq versus oligonucleotide array assessment of dose-dependent TCDD-elicited hepatic gene expression in mice

BMC genomics, 2015-05, Vol.16 (1), p.373, Article 373

2015

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Overview of a workshop on screening methods for detecting potential (anti-) estrogenic/androgenic chemicals in wildlife

Environmental toxicology and chemistry, 1998-01, Vol.17 (1), p.68-87

1998

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Inhibition of the urea cycle by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin increases serum ammonia levels in mice

The Journal of biological chemistry, 2024-01, Vol.300 (1), p.105500-105500, Article 105500

2024

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Automated Dose-Response Analysis of the Relative Hepatic Gene Expression Potency of TCDF in C57BL/6 Mice

Toxicological sciences, 2009-11, Vol.112 (1), p.221-228

2009

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Gestational and Lactational Exposure of Male Mice to Diethylstilbestrol Causes Long-Term Effects on the Testis, Sperm Fertilizing Ability in Vitro, and Testicular Gene Expression

Endocrinology (Philadelphia), 2002-08, Vol.143 (8), p.3044-3059

2002

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats

Toxicology and applied pharmacology, 2020-07, Vol.398, p.115034-115034, Article 115034

2020

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A Case for Accelerating Standards to Achieve the FAIR Principles of Environmental Health Research Experimental Data

Environmental health perspectives, 2023-06, Vol.131 (6), p.65001-65001

2023

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Use of Xenopus laevis as a model for investigating in vitro and in vivo endocrine disruption in amphibians

Environmental toxicology and chemistry, 2005-08, Vol.24 (8), p.2002-2009

2005

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Generative modeling of single-cell gene expression for dose-dependent chemical perturbations

Patterns (New York, N.Y.), 2023-08, Vol.4 (8), p.100817-100817, Article 100817

2023

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Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo- p -dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction

Molecular pharmacology, 2018-08, Vol.94 (2), p.876-884

2018

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Effects of gestational and lactational exposure to Aroclor 1242 on sperm quality and in vitro fertility in early adult and middle-aged mice

Reproductive toxicology (Elmsford, N.Y.), 2001-05, Vol.15 (3), p.281-292

2001

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Normal mammary gland morphology in pubertal female mice following in utero and lactational exposure to genistein at levels comparable to human dietary exposure

Toxicology letters, 2002-07, Vol.133 (2), p.181-191

2002

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Cell-specific AHR-driven differential gene expression in the mouse liver cell following acute TCDD exposure

Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver

Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice

A Physiologically Based Pharmacokinetic (PBPK) Modeling Framework for Mixtures of Dioxin-like Compounds

Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice

Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis

Disruption of canonical AHR-mediated induction of hepatocyte PKM2 expression compromises antioxidant defenses and increases TCDD-induced hepatotoxicity

Identification and Assessment of Endocrine Disruptors: Limitations of in Vivo and in Vitro Assays

Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice

Benchmarking of a Bayesian single cell RNAseq differential gene expression test for dose-response study designs

In Vitro Bioassays for Assessing Estrogenic Substances

Analysis of Cell–Cell Communication by Single-Nuclei RNA Sequencing Identifies AHR-Mediated Induction of NRG-ERBB Signaling

RNA-Seq versus oligonucleotide array assessment of dose-dependent TCDD-elicited hepatic gene expression in mice

Overview of a workshop on screening methods for detecting potential (anti-) estrogenic/androgenic chemicals in wildlife

Inhibition of the urea cycle by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin increases serum ammonia levels in mice

Automated Dose-Response Analysis of the Relative Hepatic Gene Expression Potency of TCDF in C57BL/6 Mice

Gestational and Lactational Exposure of Male Mice to Diethylstilbestrol Causes Long-Term Effects on the Testis, Sperm Fertilizing Ability in Vitro, and Testicular Gene Expression

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats

A Case for Accelerating Standards to Achieve the FAIR Principles of Environmental Health Research Experimental Data

Use of Xenopus laevis as a model for investigating in vitro and in vivo endocrine disruption in amphibians

Generative modeling of single-cell gene expression for dose-dependent chemical perturbations

Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo- p -dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction

Effects of gestational and lactational exposure to Aroclor 1242 on sperm quality and in vitro fertility in early adult and middle-aged mice

Normal mammary gland morphology in pubertal female mice following in utero and lactational exposure to genistein at levels comparable to human dietary exposure

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