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Animal models of Diamond-Blackfan anemia: updates and challenges

Haematologica (Roma), 2023-05, Vol.108 (5), p.1222-1231

2023

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Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis

American Journal of Physiology - Renal Physiology, 2010, Vol.298 (1), p.F142-F149

2010

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Activation of nemo-like kinase in diamond blackfan anemia suppresses early erythropoiesis by preventing mitochondrial biogenesis

The Journal of biological chemistry, 2024-08, Vol.300 (8), p.107542, Article 107542

2024

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Beyond mRNA: The role of non-coding RNAs in normal and aberrant hematopoiesis

Molecular genetics and metabolism, 2017-11, Vol.122 (3), p.28-38

2017

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Downregulation of SATB1 by miRNAs reduces megakaryocyte/erythroid progenitor expansion in preclinical models of Diamond–Blackfan anemia

Experimental hematology, 2022-07, Vol.111, p.66-78

2022

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The active component of ginseng, ginsenoside Rb1, improves erythropoiesis in models of Diamond–Blackfan anemia by targeting Nemo-like kinase

The Journal of biological chemistry, 2021-09, Vol.297 (3), p.100988-100988, Article 100988

2021

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Imatinib mesylate blocks a non‐Smad TGF‐β pathway and reduces renal fibrogenesis in vivo

The FASEB journal, 2005-01, Vol.19 (1), p.1-11

2005

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Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia

Scientific reports, 2018-03, Vol.8 (1), p.5165-11, Article 5165

2018

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Profibrotic TGFβ responses require the cooperative action of PDGF and ErbB receptor tyrosine kinases

The FASEB journal, 2013-11, Vol.27 (11), p.4444-4454

2013

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Transforming growth factor-β activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2

Cancer research (Chicago, Ill.), 2005-11, Vol.65 (22), p.10431-10440

2005

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Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2

Molecular biology of the cell, 2010-11, Vol.21 (22), p.4009-4019

2010

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Erbin and the NF2 Tumor Suppressor Merlin Cooperatively Regulate Cell-Type-Specific Activation of PAK2 by TGF-β

Developmental cell, 2009-03, Vol.16 (3), p.433-444

2009

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Peter Townsend

BMJ (Online), 2017-11, p.j5183

Wilkes, Mark

2017

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Small Molecule Inhibitor Targeting Nemo-like Kinase Improves Erythropoiesis in Human and Mouse Models of Diamond Blackfan Anemia

Blood, 2023-11, Vol.142 (Supplement 1), p.2728-2728

2023

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SATB1 Regulates Chromatin Organization and HSP70 Expression in Early Erythropoiesis and Is Downregulated in Models of Diamond Blackfan Anemia

Blood, 2021-11, Vol.138 (Supplement 1), p.2189-2189

2021

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The Serine Threonine Kinase Inhibitor Ots-167 Improves Erythropoiesis through Suppression of Nlk Activity in Diamond Blackfan Anemia Models

Blood, 2021-11, Vol.138 (Supplement 1), p.2179-2179

2021

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Nutritional Supplements, Ginseng and Leucine, Increase Erythropoiesis in Diamond Blackfan Anemia Models through Inhibition of Nemo-like Kinase

Blood, 2021-11, Vol.138 (Supplement 1), p.1129-1129

2021

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Novel Mouse Model That Recapitulates the Hematologic Phenotype of Diamond Blackfan Anemia

Blood, 2023-11, Vol.142 (Supplement 1), p.944-944

2023

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Genetic Modulators of Niclosamide Sensitivity and Resistance in Acute Myeloid Leukemia

Blood, 2020-11, Vol.136 (Supplement 1), p.29-29

2020

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Chromatin Organization By SATB1 Regulates HSP70 Induction in Early Erythropoiesis and Lost in Diamond Blackfan Anemia

Blood, 2018-11, Vol.132 (Supplement 1), p.2591-2591

2018

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Metformin Upregulates Mir-26a to Improve Erythropoiesis in Preclinical Models of Diamond Blackfan Anemia through Suppression of Nlk Expression

Blood, 2020-11, Vol.136 (Supplement 1), p.7-7

2020

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SATB1 Regulates GATA1 Protein Expression in Early Hematopoiesis and Is Deregulated in Diamond Blackfan Anemia

Blood, 2020-11, Vol.136 (Supplement 1), p.3-3

2020

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3141 – GINSENOSIDE RB1 AND METFORMIN IMPROVES ERYTHROPOIESIS IN MODELS OF DIAMOND BLACKFAN ANEMIA BY TARGETING NEMO-LIKE KINASE

Experimental hematology, 2021-08, Vol.100, p.S110-S110

2021

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Nemo-like Kinase Hyper-Activated in Erythroid Progenitors in Models of Diamond Blackfan Anemia

Blood, 2017-12, Vol.130 (Suppl_1), p.78-78

2017

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The Assessment of Residual Stress Effects on Ductile Tearing Using Continuum Damage Mechanics

Journal of pressure vessel technology, 2008-11, Vol.130 (4)

2008

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Animal models of Diamond-Blackfan anemia: updates and challenges

Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis

Activation of nemo-like kinase in diamond blackfan anemia suppresses early erythropoiesis by preventing mitochondrial biogenesis

Beyond mRNA: The role of non-coding RNAs in normal and aberrant hematopoiesis

Downregulation of SATB1 by miRNAs reduces megakaryocyte/erythroid progenitor expansion in preclinical models of Diamond–Blackfan anemia

The active component of ginseng, ginsenoside Rb1, improves erythropoiesis in models of Diamond–Blackfan anemia by targeting Nemo-like kinase

Imatinib mesylate blocks a non‐Smad TGF‐β pathway and reduces renal fibrogenesis in vivo

Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia

Profibrotic TGFβ responses require the cooperative action of PDGF and ErbB receptor tyrosine kinases

Transforming growth factor-β activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2

Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2

Erbin and the NF2 Tumor Suppressor Merlin Cooperatively Regulate Cell-Type-Specific Activation of PAK2 by TGF-β

Peter Townsend

Small Molecule Inhibitor Targeting Nemo-like Kinase Improves Erythropoiesis in Human and Mouse Models of Diamond Blackfan Anemia

SATB1 Regulates Chromatin Organization and HSP70 Expression in Early Erythropoiesis and Is Downregulated in Models of Diamond Blackfan Anemia

The Serine Threonine Kinase Inhibitor Ots-167 Improves Erythropoiesis through Suppression of Nlk Activity in Diamond Blackfan Anemia Models

Nutritional Supplements, Ginseng and Leucine, Increase Erythropoiesis in Diamond Blackfan Anemia Models through Inhibition of Nemo-like Kinase

Novel Mouse Model That Recapitulates the Hematologic Phenotype of Diamond Blackfan Anemia

Genetic Modulators of Niclosamide Sensitivity and Resistance in Acute Myeloid Leukemia

Chromatin Organization By SATB1 Regulates HSP70 Induction in Early Erythropoiesis and Lost in Diamond Blackfan Anemia

Metformin Upregulates Mir-26a to Improve Erythropoiesis in Preclinical Models of Diamond Blackfan Anemia through Suppression of Nlk Expression

SATB1 Regulates GATA1 Protein Expression in Early Hematopoiesis and Is Deregulated in Diamond Blackfan Anemia

3141 – GINSENOSIDE RB1 AND METFORMIN IMPROVES ERYTHROPOIESIS IN MODELS OF DIAMOND BLACKFAN ANEMIA BY TARGETING NEMO-LIKE KINASE

Nemo-like Kinase Hyper-Activated in Erythroid Progenitors in Models of Diamond Blackfan Anemia

The Assessment of Residual Stress Effects on Ductile Tearing Using Continuum Damage Mechanics

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