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1024 In Vivo Efficacy of C12-200 Lipid-Like SiRNA Carriers to Inhibit Hepatic Fibrosis

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-942-S-942

2012

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862 Targeting PSGL-1, a novel macrophage checkpoint, repolarizes suppressive macrophages, induces an inflammatory tumor microenvironment, and suppresses tumor growth

Journal for immunotherapy of cancer, 2020-11, Vol.8 (Suppl 3), p.A915-A915

2020

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Abstract 5001: Quantitative systems pharmacology modeling and analysis provides biological insights into anti-PD-1 dosing and predicts optimal PD-1 x TIM-3 therapeutic properties for bispecifics and fixed dose combinations in immuno-oncology

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.5001-5001

2016

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Abstract 5602: VTX-0811, a first-in-class PSGL-1 blocking monoclonal antibody, repolarizes tumor associated macrophages and induces inflammation in the tumor microenvironment, leading to suppression of tumor growth in pre-clinical studies

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.5602-5602

2022

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Abstract 5613: Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays and fresh human tumor cultures, and inhibits tumor growth in in vivo murine tumor models

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.5613-5613

2022

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Abstract P105: Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays and fresh human tumor cultures

Molecular cancer therapeutics, 2021-12, Vol.20 (12_Supplement), p.P105-P105

2021

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Abstract P107: PSGL-1 blocking antibodies repolarize tumor associated macrophages, reduce suppressive myeloid populations and induce inflammation in the tumor microenvironment, leading to suppression of tumor growth

Molecular cancer therapeutics, 2021-12, Vol.20 (12_Supplement), p.P107-P107

2021

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Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin [kappa]-chain locus

Nature Immunology, 2007-07, Vol.8 (7), p.715-722

2007

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Antibodies Targeting Human or Mouse VSIG4 Repolarize Tumor-Associated Macrophages Providing the Potential of Potent and Specific Clinical Anti-Tumor Response Induced across Multiple Cancer Types

International journal of molecular sciences, 2024-06, Vol.25 (11), p.6160

2024

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Antibody Repertoires Generated by V H Replacement and Direct V H to J H Joining

Immunity (Cambridge, Mass.), 2006, Vol.25 (1), p.43-53

2006

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Antibody Repertoires Generated by V sub(H) Replacement and Direct V sub(H) to J sub(H) Joining

Immunity (Cambridge, Mass.), 2006-07, Vol.25 (1), p.43-53

2006

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Antibody repertoires generated by VH replacement and direct VH to JH joining

Immunity (Cambridge, Mass.), 2006-07, Vol.25 (1), p.43-53

2006

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Attenuated liver fibrosis in the absence of B cells

The Journal of clinical investigation, 2005-11, Vol.115 (11), p.3072-3082

2005

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Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery

Proceedings of the National Academy of Sciences - PNAS, 2011-08, Vol.108 (32), p.12996-13001

2011

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Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

Nature communications, 2014-06, Vol.5 (1), p.4277-4277, Article 4277

2014

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Direct in vivo V sub(H) to J sub(H) rearrangement violating the 12/23 rule

The Journal of experimental medicine, 2005-02, Vol.201 (3), p.341-348

2005

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Direct in vivo VH to JH rearrangement violating the 12/23 rule

The Journal of experimental medicine, 2005-02, Vol.201 (3), p.341-348

2005

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Expression and Functional Importance of Collagen-Binding Integrins, {alpha}1{beta}1 and {alpha}2{beta}1, on Virus-Activated T Cells

The Journal of immunology (1950), 2003-09, Vol.171 (6), p.2804

2003

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Expression and functional importance of collagen-binding integrins, alpha 1 beta 1 and alpha 2 beta 1, on virus-activated T cells

The Journal of immunology (1950), 2003-09, Vol.171 (6), p.2804-2811

2003

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Expression and Functional Importance of Collagen-Binding Integrins, α1β1 and α2β1, on Virus-Activated T Cells

The Journal of immunology (1950), 2003-09, Vol.171 (6), p.2804-2811

2003

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Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements

The Journal of experimental medicine, 2003-05, Vol.197 (9), p.1165-1172

2003

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Expression of a Targeted λ1 Light Chain Gene Is Developmentally Regulated and Independent of Igκ Rearrangements

The Journal of experimental medicine, 2003-05, Vol.197 (9), p.1165-1172

2003

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Highly Effective Gene Transfection In Vivo by Alkylated Polyethylenimine

Journal of Drug Delivery, 2011-01, Vol.2011, p.204058-6

2011

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Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing

Molecular therapy. Nucleic acids, 2017-06, Vol.7 (C), p.314-323

2017

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Importance of Innate Immunity and Collagen Binding Integrin [alpha]1[beta]1 in TNBS-Induced Colitis

Immunity (Cambridge, Mass.), 2002-12, Vol.17 (6), p.769

2002

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1024 In Vivo Efficacy of C12-200 Lipid-Like SiRNA Carriers to Inhibit Hepatic Fibrosis

862 Targeting PSGL-1, a novel macrophage checkpoint, repolarizes suppressive macrophages, induces an inflammatory tumor microenvironment, and suppresses tumor growth

Abstract 5001: Quantitative systems pharmacology modeling and analysis provides biological insights into anti-PD-1 dosing and predicts optimal PD-1 x TIM-3 therapeutic properties for bispecifics and fixed dose combinations in immuno-oncology

Abstract 5602: VTX-0811, a first-in-class PSGL-1 blocking monoclonal antibody, repolarizes tumor associated macrophages and induces inflammation in the tumor microenvironment, leading to suppression of tumor growth in pre-clinical studies

Abstract 5613: Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays and fresh human tumor cultures, and inhibits tumor growth in in vivo murine tumor models

Abstract P105: Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays and fresh human tumor cultures

Abstract P107: PSGL-1 blocking antibodies repolarize tumor associated macrophages, reduce suppressive myeloid populations and induce inflammation in the tumor microenvironment, leading to suppression of tumor growth

Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin [kappa]-chain locus

Antibodies Targeting Human or Mouse VSIG4 Repolarize Tumor-Associated Macrophages Providing the Potential of Potent and Specific Clinical Anti-Tumor Response Induced across Multiple Cancer Types

Antibody Repertoires Generated by V H Replacement and Direct V H to J H Joining

Antibody Repertoires Generated by V sub(H) Replacement and Direct V sub(H) to J sub(H) Joining

Antibody repertoires generated by VH replacement and direct VH to JH joining

Attenuated liver fibrosis in the absence of B cells

Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

Direct in vivo V sub(H) to J sub(H) rearrangement violating the 12/23 rule

Direct in vivo VH to JH rearrangement violating the 12/23 rule

Expression and Functional Importance of Collagen-Binding Integrins, {alpha}1{beta}1 and {alpha}2{beta}1, on Virus-Activated T Cells

Expression and functional importance of collagen-binding integrins, alpha 1 beta 1 and alpha 2 beta 1, on virus-activated T cells

Expression and Functional Importance of Collagen-Binding Integrins, α1β1 and α2β1, on Virus-Activated T Cells

Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements

Expression of a Targeted λ1 Light Chain Gene Is Developmentally Regulated and Independent of Igκ Rearrangements

Highly Effective Gene Transfection In Vivo by Alkylated Polyethylenimine

Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing

Importance of Innate Immunity and Collagen Binding Integrin [alpha]1[beta]1 in TNBS-Induced Colitis

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