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Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

International journal of molecular sciences, 2020-02, Vol.21 (3), p.1102

2020

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From oncogenic mutation to dynamic code

Science (American Association for the Advancement of Science), 2018-08, Vol.361 (6405), p.844-845

2018

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Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

Biochemical journal, 2000-10, Vol.351 Pt 2 (2), p.289-305

Kolch, W

2000

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Computational approaches for analyzing information flow in biological networks

Science signaling, 2012-04, Vol.5 (220), p.re1

2012

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Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation

British journal of cancer, 2019-05, Vol.121 (1), p.37-50

2019

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The secret life of kinases: functions beyond catalysis

Cell communication and signaling, 2011-10, Vol.9 (1), p.23-23

2011

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Cell fate decisions are specified by the dynamic ERK interactome

Nature cell biology, 2009-12, Vol.11 (12), p.1458-1464

2009

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BGRMI: A method for inferring gene regulatory networks from time-course gene expression data and its application in breast cancer research

Scientific reports, 2016-11, Vol.6 (1), p.37140-37140, Article 37140

2016

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Coordinating ERK/MAPK signalling through scaffolds and inhibitors

Nature reviews. Molecular cell biology, 2005-11, Vol.6 (11), p.827-837

Kolch, Walter

2005

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RASSF1A Tumour Suppressor: Target the Network for Effective Cancer Therapy

Cancers, 2020-01, Vol.12 (1), p.229

2020

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The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier

Science signaling, 2010-12, Vol.3 (153), p.ra90

2010

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Crosstalk and signaling switches in mitogen-activated protein kinase cascades

Frontiers in physiology, 2012-01, Vol.3, p.355-355

2012

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Oncotherapeutic Strategies in Early Onset Colorectal Cancer

Cancers, 2023-01, Vol.15 (2), p.552

2023

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Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling

Genes, 2021-04, Vol.12 (4), p.553

2021

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Technical, bioinformatical and statistical aspects of liquid chromatography–mass spectrometry (LC–MS) and capillary electrophoresis-mass spectrometry (CE-MS) based clinical proteomics: A critical assessment

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009-05, Vol.877 (13), p.1250-1258

2009

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Proteomic Mapping of the Interactome of KRAS Mutants Identifies New Features of RAS Signalling Networks and the Mechanism of Action of Sotorasib

Cancers, 2023-08, Vol.15 (16), p.4141

2023

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On-beads digestion in conjunction with data-dependent mass spectrometry: a shortcut to quantitative and dynamic interaction proteomics

Biology (Basel, Switzerland), 2014-04, Vol.3 (2), p.320-332

2014

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Personalized Computational Models as Biomarkers

Journal of personalized medicine, 2017-09, Vol.7 (3), p.9

2017

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A comparative analysis of extracellular vesicles (EVs) from human and feline plasma

Scientific reports, 2022-06, Vol.12 (1), p.10851-10851, Article 10851

2022

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HGF Induces Epithelial-to-Mesenchymal Transition by Modulating the Mammalian Hippo/MST2 and ISG15 Pathways

Journal of proteome research, 2014-06, Vol.13 (6), p.2874-2886

2014

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Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway

Journal of cell science, 2009-02, Vol.122 (3), p.425-435

2009

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Transcriptional profiling of early differentiation of primary human mesenchymal stem cells into chondrocytes

Scientific data, 2023-11, Vol.10 (1), p.758-758, Article 758

2023

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Cell State Transition Models Stratify Breast Cancer Cell Phenotypes and Reveal New Therapeutic Targets

Cancers, 2024-06, Vol.16 (13), p.2354

2024

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Targeting KRAS in Pancreatic Cancer

Journal of personalized medicine, 2022-11, Vol.12 (11), p.1870

2022

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BTLA and PD-1 signals attenuate TCR-mediated transcriptomic changes

iScience, 2024-07, Vol.27 (7), p.110253, Article 110253

2024

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Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

From oncogenic mutation to dynamic code

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

Computational approaches for analyzing information flow in biological networks

Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation

The secret life of kinases: functions beyond catalysis

Cell fate decisions are specified by the dynamic ERK interactome

BGRMI: A method for inferring gene regulatory networks from time-course gene expression data and its application in breast cancer research

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

RASSF1A Tumour Suppressor: Target the Network for Effective Cancer Therapy

The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier

Crosstalk and signaling switches in mitogen-activated protein kinase cascades

Oncotherapeutic Strategies in Early Onset Colorectal Cancer

Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling

Technical, bioinformatical and statistical aspects of liquid chromatography–mass spectrometry (LC–MS) and capillary electrophoresis-mass spectrometry (CE-MS) based clinical proteomics: A critical assessment

Proteomic Mapping of the Interactome of KRAS Mutants Identifies New Features of RAS Signalling Networks and the Mechanism of Action of Sotorasib

On-beads digestion in conjunction with data-dependent mass spectrometry: a shortcut to quantitative and dynamic interaction proteomics

Personalized Computational Models as Biomarkers

A comparative analysis of extracellular vesicles (EVs) from human and feline plasma

HGF Induces Epithelial-to-Mesenchymal Transition by Modulating the Mammalian Hippo/MST2 and ISG15 Pathways

Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway

Transcriptional profiling of early differentiation of primary human mesenchymal stem cells into chondrocytes

Cell State Transition Models Stratify Breast Cancer Cell Phenotypes and Reveal New Therapeutic Targets

Targeting KRAS in Pancreatic Cancer

BTLA and PD-1 signals attenuate TCR-mediated transcriptomic changes

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