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KRAS Secondary Mutations That Confer Acquired Resistance to KRAS G12C Inhibitors, Sotorasib and Adagrasib, and Overcoming Strategies: Insights From In Vitro Experiments

Journal of thoracic oncology, 2021-08, Vol.16 (8), p.1321-1332

2021

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Dephasing versus collapse: lessons from the tight-binding model with noise

New journal of physics, 2021-10, Vol.23 (10), p.103025

2021

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Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer

Journal of medicinal chemistry, 2023-07, Vol.66 (14), p.9376-9400

2023

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The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML

Oncogene, 2018-05, Vol.37 (20), p.2687-2701

2018

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One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS

Journal of medicinal chemistry, 2021-05, Vol.64 (10), p.6569-6580

2021

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Combining SOS1 and MEK Inhibitors in a Murine Model of Plexiform Neurofibroma Results in Tumor Shrinkage

The Journal of pharmacology and experimental therapeutics, 2023-05, Vol.385 (2), p.106-116

2023

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Seasonal differences in Vitis vinifera L. cv. Pinot noir fruit and wine quality in relation to climate

OENO one, 2019-01, Vol.53 (2)

2019

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Towards grapevine root architectural models to adapt viticulture to drought

Frontiers in plant science, 2023-03, Vol.14, p.1162506-1162506

2023

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A mobile device to investigate the response of grapevine berries to heat stress

OENO one, 2023-09, Vol.57 (3), p.287-295

2023

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Modeling the water balance of sloped vineyards under various climate change scenarios

BIO Web of Conferences, 2015, Vol.5, p.1026

2015

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SOS1 inhibitor combinations overcome KRAS inhibitor resistance

Nature cancer, 2024-08

2024

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Erratum to: Modeling the water balance of sloped vineyards under various climate change scenarios

BIO Web of Conferences, 2015, Vol.5, p.1027

2015

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Abstract 1083: MEKi and SOS1i as a combination treatment option for KRAS mutant endometrial cancer

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.1083-1083

2023

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Klimawandel und Weinbau

Geographische Rundschau, 2016-03, Vol.68 (3), p.20-26

2016

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Abstract B083: Secondary KRAS mutations lead to acquired resistance to KRASG12D inhibitor in colorectal cancer

Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.B083-B083

2023

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P2.01-045 Nintedanib Improves Anti-Tumor Efficacy in Combination with Anti PD-1 in Syngeneic Tumor Models Sensitive and Refractory to IO Inhibition: Topic: Immune Mechanisms in Thoracic Cancer and Targeted Therapy

Journal of thoracic oncology, 2017-01, Vol.12 (1), p.S813-S813

2017

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P2.01-045 Nintedanib Improves Anti-Tumor Efficacy in Combination with Anti PD-1 in Syngeneic Tumor Models Sensitive and Refractory to IO Inhibition

Journal of thoracic oncology, 2017-01, Vol.12 (1), p.S813

2017

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Abstract CT210: Trial in Process: Phase 1 studies of BI 1701963, a SOS1::KRAS Inhibitor, in combination with MEK inhibitors, irreversible KRASG12C inhibitors or irinotecan

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.CT210-CT210

2021

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Abstract A030: Evaluation of phosphoprotein- and transcript-based pharmacodynamic biomarkers in pre-clinical studies of the novel SOS1::KRAS inhibitor BI-3406

Molecular cancer therapeutics, 2019-12, Vol.18 (12_Supplement), p.A030-A030

2019

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Downscaling of climate change scenarios for a high-resolution, site-specific assessment of drought stress risk for two viticultural regions with heterogeneous landscapes

Earth system dynamics, 2022-05, Vol.13 (2), p.911-934

2022

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Abstract 1271: In vitro and in vivo characterization of BI 1823911 - a novel KRASG12C selective small molecule inhibitor

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1271-1271

2021

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Abstract 20: Xentuzumab, a humanized IGF-1 and IGF-2 ligand neutralizing antibody, improves the antitumor efficacy of enzalutamide in preclinical models of prostate cancer

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.20-20

2017

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The Dendritic Cell HLA-Class-II/Therapeutic Factor VIII (FVIII) Peptidome Is Influenced in Unanticipated Ways By the B-Domain of FVIII and the FVIII Chaperon Protein, Von Willebrand Factor: The Outrigger and Glycosylation-Umbrella (GUMB) Hypotheses

Blood, 2019-11, Vol.134 (Supplement_1), p.161-161

2019

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BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition

KRAS Secondary Mutations That Confer Acquired Resistance to KRAS G12C Inhibitors, Sotorasib and Adagrasib, and Overcoming Strategies: Insights From In Vitro Experiments

Dephasing versus collapse: lessons from the tight-binding model with noise

Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer

The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML

One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS

Combining SOS1 and MEK Inhibitors in a Murine Model of Plexiform Neurofibroma Results in Tumor Shrinkage

Seasonal differences in Vitis vinifera L. cv. Pinot noir fruit and wine quality in relation to climate

Towards grapevine root architectural models to adapt viticulture to drought

A mobile device to investigate the response of grapevine berries to heat stress

Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance

Modeling the water balance of sloped vineyards under various climate change scenarios

SOS1 inhibitor combinations overcome KRAS inhibitor resistance

Erratum to: Modeling the water balance of sloped vineyards under various climate change scenarios

Abstract 1083: MEKi and SOS1i as a combination treatment option for KRAS mutant endometrial cancer

Klimawandel und Weinbau

Abstract B083: Secondary KRAS mutations lead to acquired resistance to KRASG12D inhibitor in colorectal cancer

P2.01-045 Nintedanib Improves Anti-Tumor Efficacy in Combination with Anti PD-1 in Syngeneic Tumor Models Sensitive and Refractory to IO Inhibition: Topic: Immune Mechanisms in Thoracic Cancer and Targeted Therapy

P2.01-045 Nintedanib Improves Anti-Tumor Efficacy in Combination with Anti PD-1 in Syngeneic Tumor Models Sensitive and Refractory to IO Inhibition

Abstract CT210: Trial in Process: Phase 1 studies of BI 1701963, a SOS1::KRAS Inhibitor, in combination with MEK inhibitors, irreversible KRASG12C inhibitors or irinotecan

Abstract A030: Evaluation of phosphoprotein- and transcript-based pharmacodynamic biomarkers in pre-clinical studies of the novel SOS1::KRAS inhibitor BI-3406

Downscaling of climate change scenarios for a high-resolution, site-specific assessment of drought stress risk for two viticultural regions with heterogeneous landscapes

Abstract 1271: In vitro and in vivo characterization of BI 1823911 - a novel KRASG12C selective small molecule inhibitor

Abstract 20: Xentuzumab, a humanized IGF-1 and IGF-2 ligand neutralizing antibody, improves the antitumor efficacy of enzalutamide in preclinical models of prostate cancer

The Dendritic Cell HLA-Class-II/Therapeutic Factor VIII (FVIII) Peptidome Is Influenced in Unanticipated Ways By the B-Domain of FVIII and the FVIII Chaperon Protein, Von Willebrand Factor: The Outrigger and Glycosylation-Umbrella (GUMB) Hypotheses

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