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PI3K inhibitors in thrombosis and cardiovascular disease

Clinical and translational medicine, 2020-01, Vol.9 (1), p.1-21

2020

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Highly efficient platelet generation in lung vasculature reproduced by microfluidics

Nature communications, 2023-07, Vol.14 (1), p.4026-4026, Article 4026

2023

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Carbonic Anhydrase Inhibitors suppress platelet procoagulant responses and in vivo thrombosis: Carbonic Anhydrase Inhibitors as Antithrombotics

Platelets (Edinburgh), 2020-10, Vol.31 (7), p.853-859

2020

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Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kα pathway

Blood, 2007-12, Vol.110 (13), p.4243-4252

Hers, Ingeborg

2007

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The Identification of ATP-citrate Lyase as a Protein Kinase B (Akt) Substrate in Primary Adipocytes

The Journal of biological chemistry, 2002-09, Vol.277 (37), p.33895-33900

2002

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Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A2

ACS central science, 2020-06, Vol.6 (6), p.995-1000

2020

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Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis

JCI insight, 2018-05, Vol.3 (10)

2018

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In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function

Blood advances, 2017-06, Vol.1 (14), p.918-932

2017

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Integrin αIIbβ3 outside-in signaling

Blood, 2017-10, Vol.130 (14), p.1607-1619

2017

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Absence of platelet phenotype in mice lacking the motor protein myosin Va

PloS one, 2013-01, Vol.8 (1), p.e53239-e53239

2013

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GPR56, a novel platelet collagen receptor that loves stress

Journal of thrombosis and haemostasis, 2021-08, Vol.19 (8), p.1848-1851

2021

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mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets

The Journal of biological chemistry, 2011-07, Vol.286 (28), p.24553-24560

2011

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204Effects of adiposity on the human proteome: Mendelian randomization study using individual-level data

International journal of epidemiology, 2021-09, Vol.50 (Supplement_1)

2021

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Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes

Biochemical journal, 2005-06, Vol.388 (Pt 2), p.713-720

2005

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Difluorinated thromboxane A2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors

British journal of pharmacology, 2024-10, Vol.181 (19), p.3685-3699

2024

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Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3 activation in patients with COVID-19

Journal of thrombosis and haemostasis, 2023-05, Vol.21 (5), p.1307-1321

2023

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Phosphoinositide 3-kinases p110α and p110β have differential roles in insulin-like growth factor-1-mediated Akt phosphorylation and platelet priming

Arteriosclerosis, thrombosis, and vascular biology, 2014-08, Vol.34 (8), p.1681-1688

2014

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Platelet dense granule secretion defects may obscure α-granule secretion mechanisms: evidence from Munc13-4–deficient platelets

Blood, 2015-05, Vol.125 (19), p.3034-3036

2015

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Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling

Cardiovascular research, 2015-07, Vol.107 (1), p.9-19

2015

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Carbonic Anhydrase Inhibitors suppress platelet procoagulant responses and in vivo thrombosis

Platelets (Edinburgh), 2020-10, Vol.31 (7), p.853-859

2020

Volltextzugriff (PDF)

mTORC2 protein-mediated protein kinase B (Akt) serine 473 phosphorylation is not required for Akt1 activity in human platelets

The Journal of biological chemistry, 2011-09, Vol.286 (35), p.31062-31062

2011

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Chemical degradation of BTK/TEC as a novel approach to inhibit platelet function

Blood advances, 2023-05, Vol.7 (9), p.1692-1696

2023

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Protein Kinase C-mediated Phosphorylation and Activation of PDE3A Regulate cAMP Levels in Human PlateletsS

The Journal of biological chemistry, 2009-05, Vol.284 (18), p.12339-12348

2009

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In-depth PtdIns(3,4,5)P 3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function

Blood advances, 2017-06, Vol.1 (14), p.918

2017

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Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A 2

ACS central science, 2020-06, Vol.6 (6), p.995-1000

2020

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PI3K inhibitors in thrombosis and cardiovascular disease

Highly efficient platelet generation in lung vasculature reproduced by microfluidics

Carbonic Anhydrase Inhibitors suppress platelet procoagulant responses and in vivo thrombosis: Carbonic Anhydrase Inhibitors as Antithrombotics

Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kα pathway

The Identification of ATP-citrate Lyase as a Protein Kinase B (Akt) Substrate in Primary Adipocytes

Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A2

Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis

In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function

Integrin αIIbβ3 outside-in signaling

Absence of platelet phenotype in mice lacking the motor protein myosin Va

GPR56, a novel platelet collagen receptor that loves stress

mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets

204Effects of adiposity on the human proteome: Mendelian randomization study using individual-level data

Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes

Difluorinated thromboxane A2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors

Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3 activation in patients with COVID-19

Phosphoinositide 3-kinases p110α and p110β have differential roles in insulin-like growth factor-1-mediated Akt phosphorylation and platelet priming

Platelet dense granule secretion defects may obscure α-granule secretion mechanisms: evidence from Munc13-4–deficient platelets

Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling

Carbonic Anhydrase Inhibitors suppress platelet procoagulant responses and in vivo thrombosis

mTORC2 protein-mediated protein kinase B (Akt) serine 473 phosphorylation is not required for Akt1 activity in human platelets

Chemical degradation of BTK/TEC as a novel approach to inhibit platelet function

Protein Kinase C-mediated Phosphorylation and Activation of PDE3A Regulate cAMP Levels in Human PlateletsS

In-depth PtdIns(3,4,5)P 3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function

Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A 2

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