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Modeling neurodegeneration in Caenorhabditis elegans

Disease models & mechanisms, 2020-10, Vol.13 (10)

2020

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Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (11), p.4013-4018

2014

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Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (38), p.E3976-E3985

2014

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The Glycolytic Enzyme, GPI, Is a Functionally Conserved Modifier of Dopaminergic Neurodegeneration in Parkinson’s Models

Cell metabolism, 2014-07, Vol.20 (1), p.145-157

2014

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Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson's Disease

Brain sciences, 2019-03, Vol.9 (4), p.73

2019

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Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration

International journal of molecular sciences, 2019-06, Vol.20 (13), p.3202

2019

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Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease

PloS one, 2016-10, Vol.11 (10), p.e0164465

2016

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Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease

Human molecular genetics, 2015-03, Vol.24 (5), p.1322-1335

2015

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Xanthine Dehydrogenase Is a Modulator of Dopaminergic Neurodegeneration in Response to Bacterial Metabolite Exposure in C. elegans

Cells (Basel, Switzerland), 2023-04, Vol.12 (8), p.1170

2023

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Attenuation of Dopaminergic Neurodegeneration in a C. elegans Parkinson's Model through Regulation of Xanthine Dehydrogenase (XDH-1) Expression by the RNA Editase, ADR-2

Journal of developmental biology, 2023-05, Vol.11 (2), p.20

2023

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Using Caenorhabditis elegans to probe toxicity of 1-alkyl-3-methylimidazolium chloride based ionic liquids

Chemical communications (Cambridge, England), 2004-03 (6), p.668

2004

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Conserved nicotine-activated neuroprotective pathways involve mitochondrial stress

iScience, 2021-03, Vol.24 (3), p.102140-102140, Article 102140

2021

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No Country for Old Worms: A Systematic Review of the Application of C. elegans to Investigate a Bacterial Source of Environmental Neurotoxicity in Parkinson's Disease

Metabolites, 2018-10, Vol.8 (4), p.70

2018

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Vacuolar protein sorting protein 41 (VPS41) at an intersection of endosomal traffic in neurodegenerative disease

Neural regeneration research, 2019-07, Vol.14 (7), p.1210-1212

2019

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Mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a Caenorhabditis elegans α-synuclein model of Parkinson’s disease

iScience, 2023-06, Vol.26 (6), p.106859-106859, Article 106859

2023

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Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease

The Journal of neuroscience, 2017-11, Vol.37 (46), p.11085-11100

2017

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Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy

NPJ Parkinson's Disease, 2022-06, Vol.8 (1), p.74-74, Article 74

2022

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Generation of stable transgenic C. elegans using microinjection

Journal of visualized experiments, 2008-08 (18)

2008

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Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates α-Synuclein Toxicity in Neurons

Science (American Association for the Advancement of Science), 2013-11, Vol.342 (6161), p.979-983

2013

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α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

Nature genetics, 2009-03, Vol.41 (3), p.308-315

2009

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C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease

Developmental dynamics, 2010-05, Vol.239 (5), p.1282-1295

2010

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Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease

Human molecular genetics, 2018-05, Vol.27 (9), p.1514-1532

2018

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Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow

Nature biomedical engineering, 2022-01, Vol.6 (1), p.76-93

2022

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Phenazine derivatives cause proteotoxicity and stress in C. elegans

Neuroscience letters, 2015-01, Vol.584, p.23-27

2015

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Integrated regulation of dopaminergic and epigenetic effectors of neuroprotection in Parkinson's disease models

Proceedings of the National Academy of Sciences - PNAS, 2023-02, Vol.120 (7), p.e2210712120

2023

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Modeling neurodegeneration in Caenorhabditis elegans

Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity

Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease

The Glycolytic Enzyme, GPI, Is a Functionally Conserved Modifier of Dopaminergic Neurodegeneration in Parkinson’s Models

Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson's Disease

Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration

Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease

Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease

Xanthine Dehydrogenase Is a Modulator of Dopaminergic Neurodegeneration in Response to Bacterial Metabolite Exposure in C. elegans

Attenuation of Dopaminergic Neurodegeneration in a C. elegans Parkinson's Model through Regulation of Xanthine Dehydrogenase (XDH-1) Expression by the RNA Editase, ADR-2

Using Caenorhabditis elegans to probe toxicity of 1-alkyl-3-methylimidazolium chloride based ionic liquids

Conserved nicotine-activated neuroprotective pathways involve mitochondrial stress

No Country for Old Worms: A Systematic Review of the Application of C. elegans to Investigate a Bacterial Source of Environmental Neurotoxicity in Parkinson's Disease

Vacuolar protein sorting protein 41 (VPS41) at an intersection of endosomal traffic in neurodegenerative disease

Mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a Caenorhabditis elegans α-synuclein model of Parkinson’s disease

Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease

Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy

Generation of stable transgenic C. elegans using microinjection

Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates α-Synuclein Toxicity in Neurons

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease

Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease

Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow

Phenazine derivatives cause proteotoxicity and stress in C. elegans

Integrated regulation of dopaminergic and epigenetic effectors of neuroprotection in Parkinson's disease models

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