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In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing

Journal of the American College of Cardiology, 2014-04, Vol.63 (15), p.1556-1566

2014

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Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells

Molecular therapy, 2011-12, Vol.19 (12), p.2186-2200

2011

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Macrophages retain hematopoietic stem cells in the spleen via VCAM-1

The Journal of experimental medicine, 2015-04, Vol.212 (4), p.497-512

2015

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The roles of individual mammalian argonautes in RNA interference in vivo

PloS one, 2014-07, Vol.9 (7), p.e101749-e101749

2014

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Antibodies Targeting Human or Mouse VSIG4 Repolarize Tumor-Associated Macrophages Providing the Potential of Potent and Specific Clinical Anti-Tumor Response Induced across Multiple Cancer Types

International journal of molecular sciences, 2024-06, Vol.25 (11), p.6160

2024

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Attenuated liver fibrosis in the absence of B cells

The Journal of clinical investigation, 2005-11, Vol.115 (11), p.3072-3082

2005

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Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery

Proceedings of the National Academy of Sciences - PNAS, 2011-08, Vol.108 (32), p.12996-13001

2011

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Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (11), p.3955-3960

2014

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VH replacement in primary immunoglobulin repertoire diversification

Proceedings of the National Academy of Sciences - PNAS, 2015-02, Vol.112 (5), p.E458-E466

2015

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Loss of NFAT5 Results in Renal Atrophy and Lack of Tonicity-Responsive Gene Expression

Proceedings of the National Academy of Sciences - PNAS, 2004-02, Vol.101 (8), p.2392-2397

2004

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Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8+ T Cell-mediated Hepatic Antiviral Immunity

Molecular therapy. Nucleic acids, 2013, Vol.2 (2), p.e72-e72, Article e72

2013

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PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Cancer research communications, 2023-10, Vol.3 (10), p.2182-2194

2023

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Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing

Molecular therapy. Nucleic acids, 2017-06, Vol.7 (C), p.314-323

2017

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Antibody repertoires generated by VH replacement and direct VH to JH joining

Immunity (Cambridge, Mass.), 2006-07, Vol.25 (1), p.43-53

2006

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Importance of Innate Immunity and Collagen Binding Integrin α1β1 in TNBS-Induced Colitis

Immunity (Cambridge, Mass.), 2002-12, Vol.17 (6), p.769-780

2002

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862 Targeting PSGL-1, a novel macrophage checkpoint, repolarizes suppressive macrophages, induces an inflammatory tumor microenvironment, and suppresses tumor growth

Journal for immunotherapy of cancer, 2020-11, Vol.8 (Suppl 3), p.A915-A915

2020

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Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells

Molecular therapy. Nucleic acids, 2012-01, Vol.1 (1), p.e4-e4, Article e4

2012

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Direct in vivo VH to JH rearrangement violating the 12/23 rule

The Journal of experimental medicine, 2005-02, Vol.201 (3), p.341-348

2005

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Highly Effective Gene Transfection In Vivo by Alkylated Polyethylenimine

Journal of Drug Delivery, 2011-01, Vol.2011, p.204058-6

2011

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Recombinant ST2 boosts hepatic Th2 response in vivo

Journal of leukocyte biology, 2007-07, Vol.82 (1), p.124-132

2007

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Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

Nature communications, 2014-06, Vol.5 (1), p.4277-4277, Article 4277

2014

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Macrophages - Controlling the Bifurcation Between Tumor Existence or Regression

Advanced biology, 2023-10, Vol.7 (10), p.e2300047-e2300047

2023

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PSGL-1 is a novel macrophage checkpoint in immuno-oncology

Journal of clinical oncology, 2020-05, Vol.38 (15_suppl), p.e15090-e15090

2020

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Abstract P105: Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays and fresh human tumor cultures

Molecular cancer therapeutics, 2021-12, Vol.20 (12_Supplement), p.P105-P105

2021

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Abstract P107: PSGL-1 blocking antibodies repolarize tumor associated macrophages, reduce suppressive myeloid populations and induce inflammation in the tumor microenvironment, leading to suppression of tumor growth

Molecular cancer therapeutics, 2021-12, Vol.20 (12_Supplement), p.P107-P107

2021

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In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing

Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells

Macrophages retain hematopoietic stem cells in the spleen via VCAM-1

The roles of individual mammalian argonautes in RNA interference in vivo

Antibodies Targeting Human or Mouse VSIG4 Repolarize Tumor-Associated Macrophages Providing the Potential of Potent and Specific Clinical Anti-Tumor Response Induced across Multiple Cancer Types

Attenuated liver fibrosis in the absence of B cells

Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

VH replacement in primary immunoglobulin repertoire diversification

Loss of NFAT5 Results in Renal Atrophy and Lack of Tonicity-Responsive Gene Expression

Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8+ T Cell-mediated Hepatic Antiviral Immunity

PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing

Antibody repertoires generated by VH replacement and direct VH to JH joining

Importance of Innate Immunity and Collagen Binding Integrin α1β1 in TNBS-Induced Colitis

862 Targeting PSGL-1, a novel macrophage checkpoint, repolarizes suppressive macrophages, induces an inflammatory tumor microenvironment, and suppresses tumor growth

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells

Direct in vivo VH to JH rearrangement violating the 12/23 rule

Highly Effective Gene Transfection In Vivo by Alkylated Polyethylenimine

Recombinant ST2 boosts hepatic Th2 response in vivo

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

Macrophages - Controlling the Bifurcation Between Tumor Existence or Regression

PSGL-1 is a novel macrophage checkpoint in immuno-oncology

Abstract P105: Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays and fresh human tumor cultures

Abstract P107: PSGL-1 blocking antibodies repolarize tumor associated macrophages, reduce suppressive myeloid populations and induce inflammation in the tumor microenvironment, leading to suppression of tumor growth

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