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Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene

Circulation (New York, N.Y.), 2011-01, Vol.123 (1), p.53-61

2011

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Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation

Science translational medicine, 2012-07, Vol.4 (144), p.144ra102

2012

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TorsinA controls TAN line assembly and the retrograde flow of dorsal perinuclear actin cables during rearward nuclear movement

The Journal of cell biology, 2017-03, Vol.216 (3), p.657-674

2017

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Apoptosis-induced translocation of nesprin-2 from the nuclear envelope to mitochondria is associated with mitochondrial dysfunction

Nucleus (Austin, Tex.), 2024-12, Vol.15 (1), p.2413501

2024

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Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy

The Journal of clinical investigation, 2007-05, Vol.117 (5), p.1282-1293

2007

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Jaundice in patients with COVID‐19

JGH open, 2021-10, Vol.5 (10), p.1166-1171

2021

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Activation of MAPK in hearts of EMD null mice: similarities between mouse models of X-linked and autosomal dominant Emery–Dreifuss muscular dystrophy

Human molecular genetics, 2007-08, Vol.16 (15), p.1884-1895

2007

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Permanently Farnesylated Prelamin A, Progeria, and Atherosclerosis

Circulation (New York, N.Y.), 2018-07, Vol.138 (3), p.283-286

2018

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Protein structural and mechanistic basis of progeroid laminopathies

The FEBS journal, 2021-05, Vol.288 (9), p.2757-2772

2021

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Abnormal p38 mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation

Human molecular genetics, 2012-10, Vol.21 (19), p.4325-4333

2012

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Nuclear envelope protein autoantigens in primary biliary cirrhosis

Hepatology research, 2007-10, Vol.37 (s3), p.S406-S411

Worman, Howard J.

2007

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Nuclear envelope-localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis

The Journal of clinical investigation, 2019-11, Vol.129 (11), p.4885-4900

2019

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Pathogenic mutations in genes encoding nuclear envelope proteins and defective nucleocytoplasmic connections

Experimental Biology and Medicine, 2019-11, Vol.244 (15), p.1333-1344

2019

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mTOR Inhibition Prolongs Survival and Has Beneficial Effects on Heart Function After Onset of Lamin A/C Gene Mutation Cardiomyopathy in Mice

Circulation. Heart failure, 2024-04, Vol.17 (4)

2024

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Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts

Nucleus (Austin, Tex.), 2015-01, Vol.6 (1), p.77-88

2015

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Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins

Nucleus (Austin, Tex.), 2012-09, Vol.3 (5), p.452-462

2012

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Postnatal development of mice with combined genetic depletions of lamin A/C, emerin and lamina-associated polypeptide 1

Human molecular genetics, 2019-08, Vol.28 (15), p.2486-2500

2019

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Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth

Human molecular genetics, 2017-01, Vol.26 (1), p.65-78

2017

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Cellular stress induces Bax-regulated nuclear bubble budding and rupture followed by nuclear protein release

Nucleus (Austin, Tex.), 2014-11, Vol.5 (6), p.527-541

2014

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Nuclear Membrane Dynamics and Reassembly in Living Cells: Targeting of an Inner Nuclear Membrane Protein in Interphase and Mitosis

The Journal of cell biology, 1997-09, Vol.138 (6), p.1193-1206

1997

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Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice

Nucleus (Austin, Tex.), 2014-05, Vol.5 (3), p.260-268

2014

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Signals and Structural Features Involved in Integral Membrane Protein Targeting to the Inner Nuclear Membrane

The Journal of cell biology, 1995-07, Vol.130 (1), p.15-27

1995

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The Amino-Terminal Domain of the Lamin B Receptor Is a Nuclear Envelope Targeting Signal

The Journal of cell biology, 1993-03, Vol.120 (5), p.1093-1100

1993

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Nuclear lamins and laminopathies: The Cell Biology of Disease

The Journal of pathology, 2012, Vol.226 (2), p.316-325

WORMAN, Howard J

2012

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How do mutations in lamins A and C cause disease?

The Journal of clinical investigation, 2004-02, Vol.113 (3), p.349-351

2004

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Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene

Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation

TorsinA controls TAN line assembly and the retrograde flow of dorsal perinuclear actin cables during rearward nuclear movement

Apoptosis-induced translocation of nesprin-2 from the nuclear envelope to mitochondria is associated with mitochondrial dysfunction

Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy

Jaundice in patients with COVID‐19

Activation of MAPK in hearts of EMD null mice: similarities between mouse models of X-linked and autosomal dominant Emery–Dreifuss muscular dystrophy

Permanently Farnesylated Prelamin A, Progeria, and Atherosclerosis

Protein structural and mechanistic basis of progeroid laminopathies

Abnormal p38 mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation

Nuclear envelope protein autoantigens in primary biliary cirrhosis

Nuclear envelope-localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis

Pathogenic mutations in genes encoding nuclear envelope proteins and defective nucleocytoplasmic connections

mTOR Inhibition Prolongs Survival and Has Beneficial Effects on Heart Function After Onset of Lamin A/C Gene Mutation Cardiomyopathy in Mice

Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts

Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins

Postnatal development of mice with combined genetic depletions of lamin A/C, emerin and lamina-associated polypeptide 1

Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth

Cellular stress induces Bax-regulated nuclear bubble budding and rupture followed by nuclear protein release

Nuclear Membrane Dynamics and Reassembly in Living Cells: Targeting of an Inner Nuclear Membrane Protein in Interphase and Mitosis

Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice

Signals and Structural Features Involved in Integral Membrane Protein Targeting to the Inner Nuclear Membrane

The Amino-Terminal Domain of the Lamin B Receptor Is a Nuclear Envelope Targeting Signal

Nuclear lamins and laminopathies: The Cell Biology of Disease

How do mutations in lamins A and C cause disease?

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