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Structure-Based Drug Design of RN486, a Potent and Selective Bruton’s Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis

Journal of medicinal chemistry, 2015-01, Vol.58 (1), p.512-516

2015

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Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes

eLife, 2023-10, Vol.12

2023

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High-Throughput Liquid Chromatography-Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II

International journal of molecular sciences, 2020-07, Vol.21 (15), p.5449

2020

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From Chemical Tools to Clinical Medicines: Nonimmunosuppressive Cyclophilin Inhibitors Derived from the Cyclosporin and Sanglifehrin Scaffolds

Journal of medicinal chemistry, 2014-09, Vol.57 (17), p.7145-7159

2014

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Highly Enantioselective Syntheses of Homopropargylic Alcohols and Dihydrofurans Catalyzed by a Bis(oxazolinyl)pyridine−Scandium Triflate Complex

Journal of the American Chemical Society, 2001-12, Vol.123 (48), p.12095-12096

2001

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Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors

Journal of medicinal chemistry, 2015-09, Vol.58 (17), p.6733-6746

2015

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Small-Molecule Inhibitors of Store-Operated Calcium Entry

ChemMedChem, 2009-05, Vol.4 (5), p.706-718

2009

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Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice

Science translational medicine, 2020-05, Vol.12 (545)

2020

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Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

The Journal of clinical investigation, 2018-05, Vol.128 (5), p.2144-2155

2018

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Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

Science translational medicine, 2015-02, Vol.7 (273), p.273ra15

2015

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Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations

Science translational medicine, 2012-12, Vol.4 (164), p.164ra161

2012

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Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline

Journal of medicinal chemistry, 2018-10, Vol.61 (20), p.9360-9370

2018

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Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling

Journal of medicinal chemistry, 2012-06, Vol.55 (11), p.5536-5545

2012

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Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (15), p.4348-4351

2008

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Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond – Part 2

Bioorganic & medicinal chemistry letters, 2019-02, Vol.29 (4), p.674-680

2019

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Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta

Journal of medicinal chemistry, 2012-09, Vol.55 (17), p.7686-7695

2012

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Finding the perfect spot for fluorine: improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (2), p.367-371

2015

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Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition

Journal of medicinal chemistry, 2012-06, Vol.55 (12), p.5887-5900

2012

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Potent Nonimmunosuppressive Cyclophilin Inhibitors With Improved Pharmaceutical Properties and Decreased Transporter Inhibition

Journal of medicinal chemistry, 2014-10, Vol.57 (20), p.8503-8516

2014

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Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease

Structure-Based Drug Design of RN486, a Potent and Selective Bruton’s Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis

Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes

High-Throughput Liquid Chromatography-Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II

From Chemical Tools to Clinical Medicines: Nonimmunosuppressive Cyclophilin Inhibitors Derived from the Cyclosporin and Sanglifehrin Scaffolds

Highly Enantioselective Syntheses of Homopropargylic Alcohols and Dihydrofurans Catalyzed by a Bis(oxazolinyl)pyridine−Scandium Triflate Complex

Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors

Small-Molecule Inhibitors of Store-Operated Calcium Entry

Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations

Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline

Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis

Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling

Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase

Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond – Part 2

Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta

Finding the perfect spot for fluorine: improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold

Diphenyl Ether Non-Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties

Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition

Potent Nonimmunosuppressive Cyclophilin Inhibitors With Improved Pharmaceutical Properties and Decreased Transporter Inhibition

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