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Pharmacokinetic/pharmacodynamic modeling in drug development

Annual review of pharmacology and toxicology, 2000-01, Vol.40 (1), p.67-95

2000

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Good Practices in Model‐Informed Drug Discovery and Development: Practice, Application, and Documentation

CPT: pharmacometrics and systems pharmacology, 2016-03, Vol.5 (3), p.93-122

2016

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Modelling response time profiles in the absence of drug concentrations: definition and performance evaluation of the K-PD model

Journal of pharmacokinetics and pharmacodynamics, 2007-02, Vol.34 (1), p.57-85

2007

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Pharmacokinetic Similarity of Biologics: Analysis Using Nonlinear Mixed-Effects Modeling

Clinical pharmacology and therapeutics, 2012-02, Vol.91 (2), p.234-242

2012

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Animal Health Modeling & Simulation Society: a new society promoting model-based approaches in veterinary pharmacology

Journal of Veterinary Pharmacology and Therapeutics, 2013-10, Vol.36 (5), p.417-419

2013

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Pharmacometrics: Opportunity for Reducing Disease Burden in the Developing World: The Case of Africa

CPT: pharmacometrics and systems pharmacology, 2013-08, Vol.2 (8), p.1-4

2013

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Modeling and Simulation to Optimize the Design and Analysis of Confirmatory Trials, Characterize Risk–Benefit, and Support Label Claims

CPT: pharmacometrics and systems pharmacology, 2013-02, Vol.2 (2), p.1-3

2013

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Population pharmacokinetics of ibandronate in Caucasian and Japanese healthy males and postmenopausal females

International journal of clinical pharmacology and therapeutics, 2006-12, Vol.44 (12), p.655-667

2006

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Relationships between exposure to saquinavir monotherapy and antiviral response in HIV-positive patients

Clinical pharmacokinetics, 1999-07, Vol.37 (1), p.75-86

1999

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Population pharmacokinetic analysis of the major metabolites of capecitabine

Journal of pharmacokinetics and pharmacodynamics, 2002-02, Vol.29 (1), p.25-47

2002

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Population pharmacokinetics of levodopa in patients with Parkinson's disease treated with tolcapone

Clinical pharmacology and therapeutics, 2000-06, Vol.67 (6), p.610-620

2000

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Practical experience and issues in designing and performing population pharmacokinetic/pharmacodynamic studies

European journal of clinical pharmacology, 1996, Vol.49 (4), p.251-254

1996

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Population pharmacokinetics of tolcapone in parkinsonian patients in dose finding studies

British journal of clinical pharmacology, 2000-01, Vol.49 (1), p.39-48

2000

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Sparse sampling for assessment of drug exposure in toxicological studies

European journal of drug metabolism and pharmacokinetics, 1996-04, Vol.21 (2), p.105-111

1996

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Population approaches in drug development. Report on an expert meeting to discuss population pharmacokinetic/pharmacodynamic software

European journal of clinical pharmacology, 1994-06, Vol.46 (5), p.389-391

1994

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Simultaneous Pharmacokinetic Modeling of a Drug and Two Metabolites: Application to Albendazole in Sheep

Journal of pharmaceutical sciences, 1991-01, Vol.80 (1), p.3-10

1991

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Zero-order absorption and linear disposition of oral colchicine in healthy volunteers

European journal of clinical pharmacology, 1989, Vol.37 (1), p.79-84

1989

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Exploratory analysis of population pharmacokinetic data from clinical trials with application to isradipine

Clinical pharmacology and therapeutics, 1991-07, Vol.50 (1), p.39-54

1991

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A mathematical model of the kinetics of 5-fluorouracil and its metabolites in cancer patients

Cancer chemotherapy and pharmacology, 1991-01, Vol.28 (2), p.123-129

1991

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L’architecture religieuse en Allemagne entre 1220 et 1350

Bulletin monumental, 2010, Vol.168 (3), p.227-242

Schurr, Marc Carel

2010

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Recherches récentes sur le gothique tardif (1350-1550)

Bulletin monumental, 2010, Vol.168 (3), p.243-280

Nußbaum, Norbert

2010

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Hyperparameter Estimation Using Stochastic Approximation with Application to Population Pharmacokinetics

Biometrics, 1988-09, Vol.44 (3), p.673-683

1988

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A semimechanistic and mechanistic population PK–PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis

British journal of clinical pharmacology, 2004-12, Vol.58 (6), p.618-631

2004

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Modelling and simulation in the development and use of anti-cancer agents : An underused tool?

Journal of pharmacokinetics and pharmacodynamics, 2004-12, Vol.31 (6), p.419-440

2004

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Population pharmacokinetics and concentration–effect relationships of capecitabine metabolites in colorectal cancer patients

British journal of clinical pharmacology, 2003-03, Vol.55 (3), p.252-263

2003

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Pharmacokinetic/pharmacodynamic modeling in drug development

Good Practices in Model‐Informed Drug Discovery and Development: Practice, Application, and Documentation

Modelling response time profiles in the absence of drug concentrations: definition and performance evaluation of the K-PD model

Pharmacokinetic Similarity of Biologics: Analysis Using Nonlinear Mixed-Effects Modeling

Animal Health Modeling & Simulation Society: a new society promoting model-based approaches in veterinary pharmacology

Pharmacometrics: Opportunity for Reducing Disease Burden in the Developing World: The Case of Africa

Modeling and Simulation to Optimize the Design and Analysis of Confirmatory Trials, Characterize Risk–Benefit, and Support Label Claims

Population pharmacokinetics of ibandronate in Caucasian and Japanese healthy males and postmenopausal females

Relationships between exposure to saquinavir monotherapy and antiviral response in HIV-positive patients

Population pharmacokinetic analysis of the major metabolites of capecitabine

Population pharmacokinetics of levodopa in patients with Parkinson's disease treated with tolcapone

Practical experience and issues in designing and performing population pharmacokinetic/pharmacodynamic studies

Population pharmacokinetics of tolcapone in parkinsonian patients in dose finding studies

Sparse sampling for assessment of drug exposure in toxicological studies

Population approaches in drug development. Report on an expert meeting to discuss population pharmacokinetic/pharmacodynamic software

Simultaneous Pharmacokinetic Modeling of a Drug and Two Metabolites: Application to Albendazole in Sheep

Zero-order absorption and linear disposition of oral colchicine in healthy volunteers

Exploratory analysis of population pharmacokinetic data from clinical trials with application to isradipine

A mathematical model of the kinetics of 5-fluorouracil and its metabolites in cancer patients

L’architecture religieuse en Allemagne entre 1220 et 1350

Recherches récentes sur le gothique tardif (1350-1550)

Hyperparameter Estimation Using Stochastic Approximation with Application to Population Pharmacokinetics

A semimechanistic and mechanistic population PK–PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis

Modelling and simulation in the development and use of anti-cancer agents : An underused tool?

Population pharmacokinetics and concentration–effect relationships of capecitabine metabolites in colorectal cancer patients

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