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A Perspective on Efflux Transport Proteins in the Liver

Clinical pharmacology and therapeutics, 2012-11, Vol.92 (5), p.599-612

2012

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Influence of Drug Transport Proteins on the Pharmacokinetics and Drug Interactions of Hiv Protease Inhibitors

Journal of pharmaceutical sciences, 2011-09, Vol.100 (9), p.3636-3654

2011

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Assessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes

Drug metabolism and disposition, 2005-03, Vol.33 (3), p.388

2005

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Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration of In Vitro, Pharmacokinetic Modeling, and Simulation Studies

Pharmaceutical research, 2008-08, Vol.25 (8), p.1851-1860

2008

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Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes

Drug metabolism and disposition, 2008-01, Vol.36 (1), p.198

2008

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Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats

Drug metabolism and disposition, 2006-04, Vol.34 (4), p.556

2006

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In Vitro–In Vivo Correlation of Hepatobiliary Drug Clearance in Humans

Clinical pharmacology and therapeutics, 2007-03, Vol.81 (3), p.406-413

2007

Volltextzugriff (PDF)

Development of a Population Pharmacokinetic Model To Describe Azithromycin Whole-Blood and Plasma Concentrations over Time in Healthy Subjects

Antimicrobial Agents and Chemotherapy, 2013-07, Vol.57 (7), p.3194-3201

2013

Volltextzugriff (PDF)

Use of sandwich-cultured human hepatocytes to predict biliary clearance of angiotensin II receptor blockers and HMG-CoA reductase inhibitors

Drug metabolism and disposition, 2009-03, Vol.37 (3), p.447

2009

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Pharmacokinetics and Safety of Fluconazole in Young Infants Supported With Extracorporeal Membrane Oxygenation

The Pediatric infectious disease journal, 2012-10, Vol.31 (10), p.1042-1047

2012

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Relationship between drug/metabolite exposure and impairment of excretory transport function

Drug metabolism and disposition, 2009-02, Vol.37 (2), p.386

2009

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In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats

Drug metabolism and disposition, 2010-10, Vol.38 (10), p.1848

2010

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Cyclophosphamide and 4‐hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis

British journal of clinical pharmacology, 2012-09, Vol.74 (3), p.445-455

2012

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Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats

Drug metabolism and disposition, 2011-03, Vol.39 (3), p.441

2011

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Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2)

Drug metabolism and disposition, 2008-11, Vol.36 (11), p.2219

2008

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Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital

Drug metabolism and disposition, 2002-08, Vol.30 (8), p.918

2002

Volltextzugriff (PDF)

Integration of Preclinical and Clinical Data with Pharmacokinetic Modeling and Simulation to Evaluate Fexofenadine as a Probe for Hepatobiliary Transport Function

Pharmaceutical research, 2009-08, Vol.26 (8), p.1942-1951

2009

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Pharmacokinetic and Pharmacodynamic Implications of P-glycoprotein Modulation

Pharmacotherapy, 2001-07, Vol.21 (7), p.778-796

2001

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Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers

Drug metabolism and disposition, 2008-05, Vol.36 (5), p.911

2008

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Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice

Drug metabolism and disposition, 2008-01, Vol.36 (1), p.61

2008

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Effect of albumin on the biliary clearance of compounds in sandwich-cultured rat hepatocytes

Drug metabolism and disposition, 2008-10, Vol.36 (10), p.2086

2008

Volltextzugriff (PDF)

Roles of P-Glycoprotein, Bcrp, and Mrp2 in Biliary Excretion of Spiramycin in Mice

Antimicrobial Agents and Chemotherapy, 2007-09, Vol.51 (9), p.3230-3234

2007

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Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver

Drug metabolism and disposition, 2009-09, Vol.37 (9), p.1916

2009

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Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment

Drug metabolism and disposition, 2002-09, Vol.30 (9), p.962

2002

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Relative bioavailability of tolvaptan administered via nasogastric tube and tolvaptan tablets swallowed intact

American journal of health-system pharmacy, 2013-07, Vol.70 (14), p.1230-1237

2013

Volltextzugriff (PDF)

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A Perspective on Efflux Transport Proteins in the Liver

Influence of Drug Transport Proteins on the Pharmacokinetics and Drug Interactions of Hiv Protease Inhibitors

Assessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes

Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration of In Vitro, Pharmacokinetic Modeling, and Simulation Studies

Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes

Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats

In Vitro–In Vivo Correlation of Hepatobiliary Drug Clearance in Humans

Development of a Population Pharmacokinetic Model To Describe Azithromycin Whole-Blood and Plasma Concentrations over Time in Healthy Subjects

Use of sandwich-cultured human hepatocytes to predict biliary clearance of angiotensin II receptor blockers and HMG-CoA reductase inhibitors

Pharmacokinetics and Safety of Fluconazole in Young Infants Supported With Extracorporeal Membrane Oxygenation

Relationship between drug/metabolite exposure and impairment of excretory transport function

In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats

Cyclophosphamide and 4‐hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis

Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats

Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2)

Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital

Integration of Preclinical and Clinical Data with Pharmacokinetic Modeling and Simulation to Evaluate Fexofenadine as a Probe for Hepatobiliary Transport Function

Pharmacokinetic and Pharmacodynamic Implications of P-glycoprotein Modulation

Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers

Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice

Effect of albumin on the biliary clearance of compounds in sandwich-cultured rat hepatocytes

Roles of P-Glycoprotein, Bcrp, and Mrp2 in Biliary Excretion of Spiramycin in Mice

Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver

Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment

Relative bioavailability of tolvaptan administered via nasogastric tube and tolvaptan tablets swallowed intact

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