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Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells

Drug metabolism and disposition, 1996-06, Vol.24 (6), p.634

1996

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In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s

Drug metabolism and disposition, 1997-10, Vol.25 (10), p.1191

1997

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The absorption, distribution, metabolism and excretion of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in rats and dogs

Drug metabolism and disposition, 2000-10, Vol.28 (10), p.1244

2000

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Ethambutol Toxicity in HIV Patients on Antiretroviral Therapy

RUHS journal of health sciences, 2023-10, Vol.2 (4), p.207

2023

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Disposition and pharmacokinetics of the antimigraine drug, rizatriptan, in humans

Drug metabolism and disposition, 2000-01, Vol.28 (1), p.89

2000

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Mesenchymal hamartoma of the liver

Computerized medical imaging and graphics, 2001, Vol.25 (1), p.61-65

2001

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In vitro and in vivo biotransformation of simvastatin, an inhibitor of HMG CoA reductase

Drug metabolism and disposition, 1990-07, Vol.18 (4), p.476

1990

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Disposition of DMP 811 (L-708,404), a potent angiotensin II receptor antagonist, in the rat, monkey, and chimpanzee

Drug metabolism and disposition, 1995-10, Vol.23 (10), p.1104

1995

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Metabolism of MK-499, a class III antiarrhythmic agent, in rats and dogs

Drug metabolism and disposition, 1998-05, Vol.26 (5), p.388

1998

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Disposition of L-738,167, a potent and long-acting fibrinogen receptor antagonist, in dogs. Dose-dependent pharmacokinetics

Drug metabolism and disposition, 1997-03, Vol.25 (3), p.355

1997

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In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist: an approach for the selection of a prodrug candidate

Drug metabolism and disposition, 1997-08, Vol.25 (8), p.978

1997

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Biotransformation of lovastatin. II. In vitro metabolism by rat and mouse liver microsomes and involvement of cytochrome P-450 in dehydrogenation of lovastatin

Drug metabolism and disposition, 1990-03, Vol.18 (2), p.218

1990

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Disposition of MK-852, a fibrinogen receptor antagonist, in rats and dogs

Drug metabolism and disposition, 1994-07, Vol.22 (4), p.631

1994

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Biotransformation of lovastatin. I. Structure elucidation of in vitro and in vivo metabolites in the rat and mouse

Drug metabolism and disposition, 1990-03, Vol.18 (2), p.203

1990

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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety

Journal of medicinal chemistry, 1999-11, Vol.42 (23), p.4778-4793

1999

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Stereoselectivity of cytochrome P-450c in the formation of naphthalene and anthracene 1,2-oxides

The Journal of biological chemistry, 1984-07, Vol.259 (14), p.8966-8973

1984

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Species and organ differences in first-pass metabolism of the ester prodrug L-751,164 in dogs and monkeys. In vivo and in vitro studies

Drug metabolism and disposition, 1996-11, Vol.24 (11), p.1263

1996

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Metabolism of antiparkinson agent dopazinol by rat liver microsomes

Drug metabolism and disposition, 1990-11, Vol.18 (6), p.1025

1990

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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains

Journal of medicinal chemistry, 1999-11, Vol.42 (23), p.4794-4803

1999

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Metabolism of Chrysene and Phenanthrene to Bay-Region Diol Epoxides by Rat Liver Enzymes

Molecular pharmacology, 1981-01, Vol.19 (1), p.168-178

1981

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Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of L-775,606, a potent 5-HT(1D) receptor agonist

Xenobiotica, 2000-01, Vol.30 (1), p.47-59

2000

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Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of L-775,606, a potent 5-HT1D receptor agonist

Xenobiotica, 2000, Vol.30 (1), p.47-59

2000

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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series

Journal of medicinal chemistry, 1999-11, Vol.42 (23), p.4804-4813

1999

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Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide

Asian Pacific journal of tropical biomedicine, 2011, Vol.1 (1), p.57-63

2011

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Regioselectivity and stereoselectivity in the metabolism of HMG-CoA reductase inhibitors

Biochemical and biophysical research communications, 1990-02, Vol.166 (3), p.1155-1162

1990

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Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells

In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s

The absorption, distribution, metabolism and excretion of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in rats and dogs

Ethambutol Toxicity in HIV Patients on Antiretroviral Therapy

Disposition and pharmacokinetics of the antimigraine drug, rizatriptan, in humans

Mesenchymal hamartoma of the liver

In vitro and in vivo biotransformation of simvastatin, an inhibitor of HMG CoA reductase

Disposition of DMP 811 (L-708,404), a potent angiotensin II receptor antagonist, in the rat, monkey, and chimpanzee

Metabolism of MK-499, a class III antiarrhythmic agent, in rats and dogs

Disposition of L-738,167, a potent and long-acting fibrinogen receptor antagonist, in dogs. Dose-dependent pharmacokinetics

In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist: an approach for the selection of a prodrug candidate

Biotransformation of lovastatin. II. In vitro metabolism by rat and mouse liver microsomes and involvement of cytochrome P-450 in dehydrogenation of lovastatin

Disposition of MK-852, a fibrinogen receptor antagonist, in rats and dogs

Biotransformation of lovastatin. I. Structure elucidation of in vitro and in vivo metabolites in the rat and mouse

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety

Stereoselectivity of cytochrome P-450c in the formation of naphthalene and anthracene 1,2-oxides

Species and organ differences in first-pass metabolism of the ester prodrug L-751,164 in dogs and monkeys. In vivo and in vitro studies

Metabolism of antiparkinson agent dopazinol by rat liver microsomes

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains

Metabolism of Chrysene and Phenanthrene to Bay-Region Diol Epoxides by Rat Liver Enzymes

Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of L-775,606, a potent 5-HT(1D) receptor agonist

Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of L-775,606, a potent 5-HT1D receptor agonist

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series

Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide

Regioselectivity and stereoselectivity in the metabolism of HMG-CoA reductase inhibitors

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