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Structure-Based Design and Synthesis of Novel Potent Na+,K+-ATPase Inhibitors Derived from a 5α,14α-Androstane Scaffold as Positive Inotropic Compounds

Journal of medicinal chemistry, 2003-08, Vol.46 (17), p.3644-3654

2003

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17α-O-(Aminoalkyl)oxime Derivatives of 3β,14β-Dihydroxy-5β-androstane and 3β-Hydroxy-14-oxoseco-D-5β-androstane as Inhibitors of Na+,K+-ATPase at the Digitalis Receptor

Journal of medicinal chemistry, 2001-11, Vol.44 (23), p.3821-3830

2001

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Synthesis and Inotropic Activity of 1-(O-Aminoalkyloximes) of Perhydroindene Derivatives as Simplified Digitalis-like Compounds Acting on the Na+,K+-ATPase

Journal of medicinal chemistry, 2002-01, Vol.45 (1), p.189-207

2002

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17β-(3-Furyl)-5β-androstane-3β,14β,17α-triol (PST 2238). A Very Potent Antihypertensive Agent with a Novel Mechanism of Action

Journal of medicinal chemistry, 1997-05, Vol.40 (11), p.1561-1564

1997

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17β-O-Aminoalkyloximes of 5β-Androstane-3β,14β-diol with Digitalis-like Activity: Synthesis, Cardiotonic Activity, Structure−Activity Relationships, and Molecular Modeling of the Na+,K+-ATPase Receptor

Journal of medicinal chemistry, 2000-06, Vol.43 (12), p.2332-2349

2000

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A New Approach to the Design of Novel Inhibitors of Na+,K+-ATPase: 17α-Substituted Seco-D 5β-Androstane as Cassaine Analogues

Journal of medicinal chemistry, 1998-07, Vol.41 (16), p.3033-3040

1998

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Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds

Journal of medicinal chemistry, 2003-08, Vol.46 (17), p.3644

2003

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Structure-based design and synthesis of novel potent Na+, K+-ATPase inhibitors derived from a 5α14α-androstane scaffold as positive inotropic compounds

Journal of medicinal chemistry, 2003, Vol.46 (17), p.3644-3654

2003

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Synthesis and Quantitative Structure−Activity Relationships of 17β-(Hydrazonomethyl)-5β-androstane-3β,14β-diol Derivatives That Bind to Na+,K+-ATPase Receptor

Journal of medicinal chemistry, 1996-08, Vol.39 (17), p.3385-3393

1996

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Synthesis and antiprotozoal activity of methylnitro derivatives of 2,2'-biimidazole

Journal of medicinal chemistry, 1972-09, Vol.15 (9), p.926-930

1972

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Digitalis-like compounds: Synthesis and biological evaluation of 3β-(aminoalkylthio) derivatives

Bioorganic & medicinal chemistry letters, 1997-02, Vol.7 (4), p.469-472

1997

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Synthesis, Cardiotonic Activity, and Structure−Activity Relationships of 17β-Guanylhydrazone Derivatives of 5β-Androstane-3β,14β-diol Acting on the Na+,K+-ATPase Receptor

Journal of medicinal chemistry, 1997-10, Vol.40 (21), p.3484-3488

1997

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Synthesis and anticonvulsant and sedative-hypnotic activity of 4-(alkylimino)-2,3-dihydro-4H-1-benzopyrans and benzothiopyrans

Journal of medicinal chemistry, 1990-10, Vol.33 (10), p.2865-2869

1990

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Digitalis-like compounds: Synthesis and biological evaluation of seco-D and D-homo derivatives

Steroids, 1996-10, Vol.61 (10), p.572-582

1996

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Synthesis of 1-(4-substituted)benzyl-6-hydroxyisoquinolines with potential activity on NA+,K+-atpase

Journal of heterocyclic chemistry, 1993-12, Vol.30 (6), p.1581-1591

1993

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Synthesis of (R,S)-6H-6-[2-(dimethylamino)ethoxycarbonyl]-[6-14C]dibenzob[b,d]pyran.HCL ([14C] FCE 20696)

Journal of labelled compounds & radiopharmaceuticals, 1989-09, Vol.27 (9), p.1035-1040

1989

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New digitalis steroids. Synthesis of 17α-amino 5β,14β-steroids by thermolysis of 17β-azidocarbonyloxymethyl derivatives

J. Chem. Soc., Perkin Trans. 1, 1995 (13), p.1755-1758

1995

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Synthesis of phenyl-substituted 2H-3,4-dihydro-3-aminomethyl-1,4-benzoxazines. Intermediates for 1H-2,3,3a,4-tetrahydroimidazo[5,1-c][1,4]benzoxazin-1-one derivatives. Part II

Journal of heterocyclic chemistry, 1983-03, Vol.20 (2), p.259-265

1983

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Preparation of 7-oxaaporphine derivatives and evaluation of their dopaminergic activity

Journal of medicinal chemistry, 1988-07, Vol.31 (7), p.1466-1471

1988

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[ 3H]imipramine displacement and 5HT uptake inhibition by tryptoline derivatives: In rat brain 5-methoxytryptoline is not the autacoid for [ 3H]imipramine recognition sites

European journal of pharmacology, 1986-04, Vol.123 (1), p.45-52

1986

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Synthesis of phenyl‐substituted 2 H ‐3,4‐dihydro‐3‐aminomethyl‐1,4‐benzoxazines. Intermediates for 1 H ‐2,3,3a,4‐tetrahydroimidazo[5,1‐ c ][1,4]benzoxazin‐1‐one derivatives. Part II

Journal of heterocyclic chemistry, 1983-03, Vol.20 (2), p.259-265

1983

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Synthesis of 6′- and 7′-(3-furylmethyl) derivatives of endo-1′,2′,3′,4′-tetrahydro-1′,4′-ethano-2′-naphthylethanol with potential activity on Na + , K + -ATPase

J. Chem. Soc., Perkin Trans. 1, 1994 (12), p.1619-1624

1994

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PST 2238: A New Antihypertensive Compound that Modulates Na+,K+‐ATPase and Antagonizes the Pressor Effect of OLF

Cardiovascular drug reviews, 1999-03, Vol.17 (1), p.39-57

1999

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Azetidine derivatives of tricyclic antidepressant agents

Journal of medicinal chemistry, 1979-02, Vol.22 (2), p.183-191

1979

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Computer-assisted studies of hypolipidemic drugs

Journal of molecular structure. Theochem, 1983, Vol.104 (1), p.135-145

1983

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Structure-Based Design and Synthesis of Novel Potent Na+,K+-ATPase Inhibitors Derived from a 5α,14α-Androstane Scaffold as Positive Inotropic Compounds

17α-O-(Aminoalkyl)oxime Derivatives of 3β,14β-Dihydroxy-5β-androstane and 3β-Hydroxy-14-oxoseco-D-5β-androstane as Inhibitors of Na+,K+-ATPase at the Digitalis Receptor

Synthesis and Inotropic Activity of 1-(O-Aminoalkyloximes) of Perhydroindene Derivatives as Simplified Digitalis-like Compounds Acting on the Na+,K+-ATPase

17β-(3-Furyl)-5β-androstane-3β,14β,17α-triol (PST 2238). A Very Potent Antihypertensive Agent with a Novel Mechanism of Action

17β-O-Aminoalkyloximes of 5β-Androstane-3β,14β-diol with Digitalis-like Activity: Synthesis, Cardiotonic Activity, Structure−Activity Relationships, and Molecular Modeling of the Na+,K+-ATPase Receptor

A New Approach to the Design of Novel Inhibitors of Na+,K+-ATPase: 17α-Substituted Seco-D 5β-Androstane as Cassaine Analogues

Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds

Structure-based design and synthesis of novel potent Na+, K+-ATPase inhibitors derived from a 5α14α-androstane scaffold as positive inotropic compounds

Synthesis and Quantitative Structure−Activity Relationships of 17β-(Hydrazonomethyl)-5β-androstane-3β,14β-diol Derivatives That Bind to Na+,K+-ATPase Receptor

Synthesis and antiprotozoal activity of methylnitro derivatives of 2,2'-biimidazole

Digitalis-like compounds: Synthesis and biological evaluation of 3β-(aminoalkylthio) derivatives

Synthesis, Cardiotonic Activity, and Structure−Activity Relationships of 17β-Guanylhydrazone Derivatives of 5β-Androstane-3β,14β-diol Acting on the Na+,K+-ATPase Receptor

Synthesis and anticonvulsant and sedative-hypnotic activity of 4-(alkylimino)-2,3-dihydro-4H-1-benzopyrans and benzothiopyrans

Digitalis-like compounds: Synthesis and biological evaluation of seco-D and D-homo derivatives

Synthesis of 1-(4-substituted)benzyl-6-hydroxyisoquinolines with potential activity on NA+,K+-atpase

Synthesis of (R,S)-6H-6-[2-(dimethylamino)ethoxycarbonyl]-[6-14C]dibenzob[b,d]pyran.HCL ([14C] FCE 20696)

New digitalis steroids. Synthesis of 17α-amino 5β,14β-steroids by thermolysis of 17β-azidocarbonyloxymethyl derivatives

Synthesis of phenyl-substituted 2H-3,4-dihydro-3-aminomethyl-1,4-benzoxazines. Intermediates for 1H-2,3,3a,4-tetrahydroimidazo[5,1-c][1,4]benzoxazin-1-one derivatives. Part II

Preparation of 7-oxaaporphine derivatives and evaluation of their dopaminergic activity

[ 3H]imipramine displacement and 5HT uptake inhibition by tryptoline derivatives: In rat brain 5-methoxytryptoline is not the autacoid for [ 3H]imipramine recognition sites

Synthesis of phenyl‐substituted 2 H ‐3,4‐dihydro‐3‐aminomethyl‐1,4‐benzoxazines. Intermediates for 1 H ‐2,3,3a,4‐tetrahydroimidazo[5,1‐ c ][1,4]benzoxazin‐1‐one derivatives. Part II

Synthesis of 6′- and 7′-(3-furylmethyl) derivatives of endo-1′,2′,3′,4′-tetrahydro-1′,4′-ethano-2′-naphthylethanol with potential activity on Na + , K + -ATPase

PST 2238: A New Antihypertensive Compound that Modulates Na+,K+‐ATPase and Antagonizes the Pressor Effect of OLF

Azetidine derivatives of tricyclic antidepressant agents

Computer-assisted studies of hypolipidemic drugs

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