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Development and Therapeutic Implications of Selective Histone Deacetylase 6 Inhibitors

Journal of medicinal chemistry, 2013-08, Vol.56 (16), p.6297-6313

2013

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Development and characterization of rabbit monoclonal antibodies that recognize human spermine oxidase and application to immunohistochemistry of human cancer tissues

PloS one, 2022-04, Vol.17 (4), p.e0267046

2022

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Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex

eLife, 2018-06, Vol.7

2018

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Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

PloS one, 2019-03, Vol.14 (3), p.e0213095

2019

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Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes

Wellcome open research, 2023, Vol.8, p.146-146

2023

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Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity

The Journal of clinical investigation, 2020-04, Vol.130 (4), p.1830-1842

2020

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Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor

Communications biology, 2022-08, Vol.5 (1), p.787-787, Article 787

2022

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Site-Specific Protein Labeling with N‑Hydroxysuccinimide-Esters and the Analysis of Ubiquitin Ligase Mechanisms

Journal of the American Chemical Society, 2018-08, Vol.140 (30), p.9374-9378

2018

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Inhibition of the CoREST Repressor Complex Promotes Wound Re-Epithelialization through the Regulation of Keratinocyte Migration

Journal of investigative dermatology, 2024-02, Vol.144 (2), p.378-386.e2

2024

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The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma

The Journal of clinical investigation, 2024-03, Vol.134 (6)

2024

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RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells

Nucleic acids research, 2012-08, Vol.40 (15), p.7347

2012

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Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in PIK3CA -Mutant Colorectal Cancer

Molecular cancer research, 2020-02, Vol.18 (2), p.264-277

2020

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An Optimized RAD51 Inhibitor That Disrupts Homologous Recombination without Requiring Michael Acceptor Reactivity

Journal of medicinal chemistry, 2013-01, Vol.56 (1), p.254-263

2013

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Second-Generation Histone Deacetylase 6 Inhibitors Enhance the Immunosuppressive Effects of Foxp3+ T-Regulatory Cells

Journal of medicinal chemistry, 2012-01, Vol.55 (2), p.639-651

2012

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Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot–Marie–Tooth Disease

ACS chemical neuroscience, 2016-02, Vol.7 (2), p.240-258

2016

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A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1

ACS chemical biology, 2014-06, Vol.9 (6), p.1284-1293

2014

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Exploration of the labeling of [11C]tubastatin A at the hydroxamic acid site with [11C]carbon monoxide

Journal of labelled compounds & radiopharmaceuticals, 2016-01, Vol.59 (1), p.9-13

2016

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Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase6 and Exhibit Neuroprotection in Cortical Neuron Models of Oxidative Stress

ChemMedChem, 2012-03, Vol.7 (3), p.425

2012

Volltextzugriff (PDF)

Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase 6 and Exhibit Neuroprotection in Cortical Neuron Models of Oxidative Stress

ChemMedChem, 2012-03, Vol.7 (3), p.425-439

2012

Volltextzugriff (PDF)

An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine2A Receptor

Chembiochem : a European journal of chemical biology, 2016-10, Vol.17 (20), p.1951-1960

2016

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An Fc Domain Protein–Small Molecule Conjugate as an Enhanced Immunomodulator

Journal of the American Chemical Society, 2014-03, Vol.136 (9), p.3370-3373

2014

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Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (5), p.1346-1348

2007

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The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma

The Journal of clinical investigation, 2024-03, Vol.134 (6), p.1-21

2024

Volltextzugriff (PDF)

Site-specific Protein Labeling with NHS-Esters and the Analysis of Ubiquitin Ligase Mechanisms

Journal of the American Chemical Society, 2018-07, Vol.140 (30), p.9374-9378

2018

Volltextzugriff (PDF)

Analysis of CoREST Complex‐Chromatin Interactions with Chemical Tools

The FASEB journal, 2018-04, Vol.32 (S1), p.524.7-524.7

2018

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Development and Therapeutic Implications of Selective Histone Deacetylase 6 Inhibitors

Development and characterization of rabbit monoclonal antibodies that recognize human spermine oxidase and application to immunohistochemistry of human cancer tissues

Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes

Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity

Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor

Site-Specific Protein Labeling with N‑Hydroxysuccinimide-Esters and the Analysis of Ubiquitin Ligase Mechanisms

Inhibition of the CoREST Repressor Complex Promotes Wound Re-Epithelialization through the Regulation of Keratinocyte Migration

The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma

RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells

Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in PIK3CA -Mutant Colorectal Cancer

An Optimized RAD51 Inhibitor That Disrupts Homologous Recombination without Requiring Michael Acceptor Reactivity

Second-Generation Histone Deacetylase 6 Inhibitors Enhance the Immunosuppressive Effects of Foxp3+ T-Regulatory Cells

Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot–Marie–Tooth Disease

A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1

Exploration of the labeling of [11C]tubastatin A at the hydroxamic acid site with [11C]carbon monoxide

Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase6 and Exhibit Neuroprotection in Cortical Neuron Models of Oxidative Stress

Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase 6 and Exhibit Neuroprotection in Cortical Neuron Models of Oxidative Stress

An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine2A Receptor

An Fc Domain Protein–Small Molecule Conjugate as an Enhanced Immunomodulator

Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives

The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma

Site-specific Protein Labeling with NHS-Esters and the Analysis of Ubiquitin Ligase Mechanisms

Analysis of CoREST Complex‐Chromatin Interactions with Chemical Tools

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