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Muscarinic receptors in the bladder: from basic research to therapeutics

British journal of pharmacology, 2006-02, Vol.147 (S2), p.S80-S87

Hegde, Sharath S.

2006

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Revefenacin Absorption, Metabolism, and Excretion in Healthy Subjects and Pharmacological Activity of Its Major Metabolite

Drug metabolism and disposition, 2020-12, Vol.48 (12), p.1312-1320

2020

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Are blood vessels a target to treat lower urinary tract dysfunction?

Naunyn-Schmiedeberg's archives of pharmacology, 2015-07, Vol.388 (7), p.687-694

2015

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A Multivalent Approach to Drug Discovery for Novel Antibiotics

Journal of antibiotics, 2008-10, Vol.61 (10), p.595-602

2008

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Discovery of (R)‑1-(3-((2-Chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1′-Biphenyl]-2-ylcarbamate (TD-5959, GSK961081, Batefenterol): First-in-Class Dual Pharmacology Multivalent Muscarinic Antagonist and β2 Agonist (MABA) for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)

Journal of medicinal chemistry, 2015-03, Vol.58 (6), p.2609-2622

2015

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Efficacy of telavancin, a lipoglycopeptide antibiotic, in experimental models of Gram-positive infection

Expert review of anti-infective therapy, 2014-12, Vol.12 (12), p.1463-1475

2014

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Concomitant Angiotensin AT1 Receptor Antagonism and Neprilysin Inhibition Produces Omapatrilat-like Antihypertensive Effects Without Promoting Tracheal Plasma Extravasation in the Rat

Journal of cardiovascular pharmacology, 2011-04, Vol.57 (4), p.495-504

2011

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Discovery of TD-0212, an Orally Active Dual Pharmacology AT 1 Antagonist and Neprilysin Inhibitor (ARNI)

ACS medicinal chemistry letters, 2019-01, Vol.10 (1), p.86-91

2019

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Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties

The Journal of pharmacology and experimental therapeutics, 2014-10, Vol.351 (1), p.190

2014

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Pharmacological properties of revefenacin (TD‐4208), a novel, nebulized long‐acting, and lung selective muscarinic antagonist, at human recombinant muscarinic receptors and in rat, guinea pig, and human isolated airway tissues

Pharmacology research & perspectives, 2018-06, Vol.6 (3), p.e00400-n/a

2018

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Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI)

ACS medicinal chemistry letters, 2019-01, Vol.10 (1), p.86-91

2019

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Efficacy of telavancin in a murine model of bacteraemia induced by methicillin-resistant Staphylococcus aureus

Journal of antimicrobial chemotherapy, 2006-08, Vol.58 (2), p.462-465

2006

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Comparative pharmacology of recombinant human M3 and M5 muscarinic receptors expressed in CHO‐K1 cells

British journal of pharmacology, 1999-05, Vol.127 (2), p.590-596

1999

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A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (4), p.939-943

2013

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Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β2 -adrenoceptor agonist (MABA)

Pulmonary pharmacology & therapeutics, 2012-10, Vol.25 (5), p.357-363

2012

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Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β(2)-adrenoceptor agonist (MABA)

Pulmonary pharmacology & therapeutics, 2012-10, Vol.25 (5), p.357-363

2012

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Treatment of the overactive bladder syndrome with muscarinic receptor antagonists: a matter of metabolites?

Naunyn-Schmiedeberg's archives of pharmacology, 2006-11, Vol.374 (2), p.79-85

2006

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Application of the classical Einthoven model of bronchoconstriction to the study of inhaled bronchodilators in rodents

Journal of pharmacological and toxicological methods, 2011-01, Vol.63 (1), p.89-95

2011

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Combating the growing problem of methicillin-resistant Staphylococcus aureus: do the newer antibiotics represent a better alternative to vancomycin?

Expert review of anti-infective therapy, 2007-06, Vol.5 (3), p.333-335

2007

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Pharmacological analysis of the interaction of antimuscarinic drugs at M2 and M3 muscarinic receptors in vivo using the pithed rat assay

Naunyn-Schmiedeberg's archives of pharmacology, 2008, Vol.376 (5), p.341-349

2008

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In Vitro Muscarinic Receptor Radioligand‐Binding Assays

Current Protocols in Pharmacology, 2010-03, Vol.48 (1), p.1.33.1-1.33.18

2010

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Antimuscarinics for the treatment of overactive bladder: current options and emerging therapies

Current opinion in investigational drugs (London, England : 2000), 2004-01, Vol.5 (1), p.40

2004

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Catecholamine modulatory effects of nepicastat (RS‐25560‐197), a novel, potent and selective inhibitor of dopamine‐β‐hydroxylase

British journal of pharmacology, 1997-08, Vol.121 (8), p.1803-1809

1997

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Are blood vessels a target to treat lower urinary tract dysfunction?

Naunyn-Schmiedeberg's archives of pharmacology, 2015-05, Vol.388 (7), p.687-694

2015

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Functional characterization of rat submaxillary gland muscarinic receptors using microphysiometry

British journal of pharmacology, 2001-04, Vol.132 (7), p.1606-1614

2001

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Muscarinic receptors in the bladder: from basic research to therapeutics

Revefenacin Absorption, Metabolism, and Excretion in Healthy Subjects and Pharmacological Activity of Its Major Metabolite

Are blood vessels a target to treat lower urinary tract dysfunction?

A Multivalent Approach to Drug Discovery for Novel Antibiotics

Efficacy of telavancin, a lipoglycopeptide antibiotic, in experimental models of Gram-positive infection

Concomitant Angiotensin AT1 Receptor Antagonism and Neprilysin Inhibition Produces Omapatrilat-like Antihypertensive Effects Without Promoting Tracheal Plasma Extravasation in the Rat

Discovery of TD-0212, an Orally Active Dual Pharmacology AT 1 Antagonist and Neprilysin Inhibitor (ARNI)

Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties

Pharmacological properties of revefenacin (TD‐4208), a novel, nebulized long‐acting, and lung selective muscarinic antagonist, at human recombinant muscarinic receptors and in rat, guinea pig, and human isolated airway tissues

Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI)

Efficacy of telavancin in a murine model of bacteraemia induced by methicillin-resistant Staphylococcus aureus

Comparative pharmacology of recombinant human M3 and M5 muscarinic receptors expressed in CHO‐K1 cells

A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma

Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β2 -adrenoceptor agonist (MABA)

Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β(2)-adrenoceptor agonist (MABA)

Treatment of the overactive bladder syndrome with muscarinic receptor antagonists: a matter of metabolites?

Application of the classical Einthoven model of bronchoconstriction to the study of inhaled bronchodilators in rodents

Combating the growing problem of methicillin-resistant Staphylococcus aureus: do the newer antibiotics represent a better alternative to vancomycin?

Pharmacological analysis of the interaction of antimuscarinic drugs at M2 and M3 muscarinic receptors in vivo using the pithed rat assay

In Vitro Muscarinic Receptor Radioligand‐Binding Assays

Antimuscarinics for the treatment of overactive bladder: current options and emerging therapies

Catecholamine modulatory effects of nepicastat (RS‐25560‐197), a novel, potent and selective inhibitor of dopamine‐β‐hydroxylase

Are blood vessels a target to treat lower urinary tract dysfunction?

Functional characterization of rat submaxillary gland muscarinic receptors using microphysiometry

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