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Persistence Pays Off: Milvexian Emerges from the Industry’s Longstanding Search for Orally Bioavailable Factor XIa Inhibitors

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.1767-1769

Goodwin, Nicole C

2022

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Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes

Journal of medicinal chemistry, 2017-01, Vol.60 (2), p.710-721

2017

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Design and Characterization of 1,3-Dihydro‑2H‑benzo[d]azepin-2-ones as Rule-of‑5 Compliant Bivalent BET Inhibitors

ACS medicinal chemistry letters, 2023-09, Vol.14 (9), p.1231-1236

2023

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LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice

The Journal of pharmacology and experimental therapeutics, 2017-07, Vol.362 (1), p.85

2017

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Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma

ACS medicinal chemistry letters, 2015-01, Vol.6 (1), p.84-88

2015

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Site-Selective C–H Alkylation of Piperazine Substrates via Organic Photoredox Catalysis

Organic letters, 2020-01, Vol.22 (2), p.679-683

2020

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The First Enantioselective Organocatalytic Mukaiyama−Michael Reaction: A Direct Method for the Synthesis of Enantioenriched γ-Butenolide Architecture

Journal of the American Chemical Society, 2003-02, Vol.125 (5), p.1192-1194

2003

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Biocatalysis in Medicinal Chemistry: Challenges to Access and Drivers for Adoption

ACS medicinal chemistry letters, 2019-10, Vol.10 (10), p.1363-1366

2019

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Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement

Bioorganic & medicinal chemistry, 2024-02, Vol.100, p.117618-117618, Article 117618

2024

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Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation

ACS medicinal chemistry letters, 2015-01, Vol.6 (1), p.53-57

2015

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Enhancing the Visibility of Women in the ACS Division of Medicinal Chemistry (ACS MEDI)

ACS medicinal chemistry letters, 2023-04, Vol.14 (4), p.345-349

2023

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Empowering Voices: Inspiring Women in Medicinal Chemistry

ACS medicinal chemistry letters, 2024-04, Vol.15 (4), p.424-431

2024

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Ischemic preconditioning, retinal neuroprotection and histone deacetylase activities

Experimental eye research, 2016-05, Vol.146, p.269-275

2016

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Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors

ACS medicinal chemistry letters, 2019-11, Vol.10 (11), p.1518-1523

2019

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Novel l-Xylose Derivatives as Selective Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes

Journal of medicinal chemistry, 2009-10, Vol.52 (20), p.6201-6204

2009

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LP‐925219 maximizes urinary glucose excretion in mice by inhibiting both renal SGLT1 and SGLT2

Pharmacology research & perspectives, 2015-03, Vol.3 (2), p.e00129-n/a

2015

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LP ‐925219 maximizes urinary glucose excretion in mice by inhibiting both renal SGLT 1 and SGLT 2

Pharmacology research & perspectives, 2015-03, Vol.3 (2)

2015

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Copper-Nitroxyl-Catalyzed α-Oxygenation of Cyclic Secondary Amines Including Application to Late-Stage Functionalization

Journal of the American Chemical Society, 2024-05

2024

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Design and Characterization of 1,3-Dihydro-2 H -benzo[ d ]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors

ACS medicinal chemistry letters, 2023-09, Vol.14 (9), p.1231-1236

2023

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The First Enantioselective Organocatalytic Mukaiyama-Michael Reaction: A Direct Method for the Synthesis of Enantioenriched γ-Butenolide Architecture

ChemInform, 2003-06, Vol.34 (25), p.no-no

2003

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Mass Spectrometry Imaging of Cassette-Dosed Drugs for Higher Throughput Pharmacokinetic and Biodistribution Analysis

Analytical chemistry (Washington), 2014-08, Vol.86 (16), p.8473-8480

2014

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Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (3), p.1053-1058

2013

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EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model

PLoS pathogens, 2021-03, Vol.17 (3), p.e1009428-e1009428

2021

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Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Cell, 2021-01, Vol.184 (1), p.64-75.e11

2021

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Persistence Pays Off: Milvexian Emerges from the Industry’s Longstanding Search for Orally Bioavailable Factor XIa Inhibitors

Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes

Design and Characterization of 1,3-Dihydro‑2H‑benzo[d]azepin-2-ones as Rule-of‑5 Compliant Bivalent BET Inhibitors

LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice

Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma

Site-Selective C–H Alkylation of Piperazine Substrates via Organic Photoredox Catalysis

The First Enantioselective Organocatalytic Mukaiyama−Michael Reaction: A Direct Method for the Synthesis of Enantioenriched γ-Butenolide Architecture

Biocatalysis in Medicinal Chemistry: Challenges to Access and Drivers for Adoption

Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement

Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation

Enhancing the Visibility of Women in the ACS Division of Medicinal Chemistry (ACS MEDI)

Empowering Voices: Inspiring Women in Medicinal Chemistry

Ischemic preconditioning, retinal neuroprotection and histone deacetylase activities

Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors

Novel l-Xylose Derivatives as Selective Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes

LP‐925219 maximizes urinary glucose excretion in mice by inhibiting both renal SGLT1 and SGLT2

LP ‐925219 maximizes urinary glucose excretion in mice by inhibiting both renal SGLT 1 and SGLT 2

Copper-Nitroxyl-Catalyzed α-Oxygenation of Cyclic Secondary Amines Including Application to Late-Stage Functionalization

Design and Characterization of 1,3-Dihydro-2 H -benzo[ d ]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors

Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors

The First Enantioselective Organocatalytic Mukaiyama-Michael Reaction: A Direct Method for the Synthesis of Enantioenriched γ-Butenolide Architecture

Mass Spectrometry Imaging of Cassette-Dosed Drugs for Higher Throughput Pharmacokinetic and Biodistribution Analysis

Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing

EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

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