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Maximizing Diversity from a Kinase Screen: Identification of Novel and Selective pan-Trk Inhibitors for Chronic Pain

Journal of medicinal chemistry, 2014-07, Vol.57 (13), p.5800-5816

2014

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MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate

ACS medicinal chemistry letters, 2018-07, Vol.9 (7), p.652-656

2018

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A New Synthesis of Naphthyridinones and Quinolinones: Palladium-Catalyzed Amidation of o-Carbonyl-Substituted Aryl Halides

Organic letters, 2004-07, Vol.6 (14), p.2433-2435

2004

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Imidazopyridine CB2 agonists: Optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2354-2358

2011

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The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation

Current topics in medicinal chemistry, 2005-01, Vol.5 (2), p.109-125

2005

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Development of the Copper-Catalyzed Olefin Aziridination Reaction

Journal of the American Chemical Society, 1994-04, Vol.116 (7), p.2742-2753

1994

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A Mild Method for the Formation and in Situ Reaction of Imidoyl Chlorides: Conversion of Pyridine-1-oxides to 2-Aminopyridine Amides

Organic letters, 2002-09, Vol.4 (18), p.3127-3129

2002

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Bis(oxazoline)-copper complexes as chiral catalysts for the enantioselective aziridination of olefins

Journal of the American Chemical Society, 1993-06, Vol.115 (12), p.5328-5329

1993

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Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer

Molecular cancer therapeutics, 2019-11, Vol.18 (11), p.1926-1936

2019

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Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo

Journal of medicinal chemistry, 2019-03, Vol.62 (5), p.2708-2719

2019

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Discovery of a 3‑(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.2983-2992

2017

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Copper-catalyzed aziridination of olefins by (N-(p-toluenesulfonyl)imino)phenyliodinane

Journal of organic chemistry, 1991-11, Vol.56 (24), p.6744-6746

1991

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Glycals in Organic Synthesis: The Evolution of Comprehensive Strategies for the Assembly of Oligosaccharides and Glycoconjugates of Biological Consequence

Angewandte Chemie International Edition, 1996-07, Vol.35 (13-14), p.1380-1419

1996

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Novel Miniaturized Drug Conjugate Leverages HSP90-driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors

Molecular cancer therapeutics, 2020-08, Vol.19 (8), p.1613-1622

2020

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Solid-Supported Synthesis of Imidazoles: A Strategy for Direct Resin-Attachment to the Imidazole Core

Journal of organic chemistry, 1998-05, Vol.63 (9), p.2800-2801

1998

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Structural characterization of nonactive site, TrkA-selective kinase inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (3), p.E297-E306

2017

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Stereoselective aldol reactions of chlorotitanium enolates. An efficient method for the assemblage of polypropionate-related synthons

Journal of the American Chemical Society, 1991, Vol.113 (3), p.1047-1049

1991

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Identification and in Vivo Evaluation of Liver X Receptor β‑Selective Agonists for the Potential Treatment of Alzheimer’s Disease

Journal of medicinal chemistry, 2016-04, Vol.59 (7), p.3489-3498

2016

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Simple Method Provides Resolution of Albumin, Lipoprotein, Free Fraction, and Chylomicron To Enhance the Utility of Protein Binding Assays

Journal of medicinal chemistry, 2015-02, Vol.58 (3), p.1420-1425

2015

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The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors

Current cancer drug targets, 2008-02, Vol.8 (1), p.7-18

2008

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MK-7622: A First-in-Class M 1 Positive Allosteric Modulator Development Candidate

ACS medicinal chemistry letters, 2018-07, Vol.9 (7), p.652-656

2018

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New procedure for the direct generation of titanium enolates. Diastereoselective bond constructions with representative electrophiles

Journal of the American Chemical Society, 1990-10, Vol.112 (22), p.8215-8216

1990

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Discovery of a Selective Allosteric M1 Receptor Modulator with Suitable Development Properties Based on a Quinolizidinone Carboxylic Acid Scaffold

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4773-4780

2011

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Benzimidazole CB2 agonists: design, synthesis and SAR

Bioorganic & medicinal chemistry letters, 2014-02, Vol.24 (4), p.1218-1221

2014

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Maximizing Diversity from a Kinase Screen: Identification of Novel and Selective pan-Trk Inhibitors for Chronic Pain

MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate

A New Synthesis of Naphthyridinones and Quinolinones: Palladium-Catalyzed Amidation of o-Carbonyl-Substituted Aryl Halides

Imidazopyridine CB2 agonists: Optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy

The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation

Development of the Copper-Catalyzed Olefin Aziridination Reaction

A Mild Method for the Formation and in Situ Reaction of Imidoyl Chlorides: Conversion of Pyridine-1-oxides to 2-Aminopyridine Amides

Bis(oxazoline)-copper complexes as chiral catalysts for the enantioselective aziridination of olefins

Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer

Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo

Discovery of a 3‑(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity

Copper-catalyzed aziridination of olefins by (N-(p-toluenesulfonyl)imino)phenyliodinane

Potent N-(1,3-Thiazol-2-yl)pyridin-2-amine Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors with Excellent Pharmacokinetics and Low Affinity for the hERG Ion Channel

Glycals in Organic Synthesis: The Evolution of Comprehensive Strategies for the Assembly of Oligosaccharides and Glycoconjugates of Biological Consequence

Novel Miniaturized Drug Conjugate Leverages HSP90-driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors

Solid-Supported Synthesis of Imidazoles: A Strategy for Direct Resin-Attachment to the Imidazole Core

Structural characterization of nonactive site, TrkA-selective kinase inhibitors

Stereoselective aldol reactions of chlorotitanium enolates. An efficient method for the assemblage of polypropionate-related synthons

Identification and in Vivo Evaluation of Liver X Receptor β‑Selective Agonists for the Potential Treatment of Alzheimer’s Disease

Simple Method Provides Resolution of Albumin, Lipoprotein, Free Fraction, and Chylomicron To Enhance the Utility of Protein Binding Assays

The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors

MK-7622: A First-in-Class M 1 Positive Allosteric Modulator Development Candidate

New procedure for the direct generation of titanium enolates. Diastereoselective bond constructions with representative electrophiles

Discovery of a Selective Allosteric M1 Receptor Modulator with Suitable Development Properties Based on a Quinolizidinone Carboxylic Acid Scaffold

Benzimidazole CB2 agonists: design, synthesis and SAR

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