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Prospects for Antibacterial Discovery and Development

Journal of the American Chemical Society, 2021-12, Vol.143 (50), p.21127-21142

2021

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In situ assembly of enzyme inhibitors using extended tethering

Nature biotechnology, 2003-03, Vol.21 (3), p.308-314

2003

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Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions

Journal of medicinal chemistry, 1994-05, Vol.37 (10), p.1385-1401

1994

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Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries

Journal of medicinal chemistry, 1994-04, Vol.37 (9), p.1233-1251

1994

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Exercise and rehabilitation of the cancer patient

Urologic oncology, 2008-03, Vol.26 (2), p.204-204

Gordon, Eric M., P.T

2008

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Combinatorial modification of natural products: Synthesis and in vitro analysis of derivatives of thiazole peptide antibiotic GE2270 A: A-ring modifications

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (20), p.3409-3414

2003

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Site-Directed Ligand Discovery

Proceedings of the National Academy of Sciences - PNAS, 2000-08, Vol.97 (17), p.9367-9372

2000

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Aminoethylenes: A Tetrahedral Intermediate Isostere Yielding Potent Inhibitors of the Aspartyl Protease BACE-1

Journal of medicinal chemistry, 2006-02, Vol.49 (3), p.839-842

2006

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Selective Reduction of Peptide Isothiazolidin-3-ones

Organic letters, 2006-12, Vol.8 (25), p.5697-5699

2006

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Farnesyl Diphosphate-Based Inhibitors of Ras Farnesyl Protein Transferase

Journal of medicinal chemistry, 1995-07, Vol.38 (15), p.2906-2921

1995

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Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design

Journal of medicinal chemistry, 2002-11, Vol.45 (23), p.5005-5022

2002

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Versatile Approach To Encoding Combinatorial Organic Syntheses Using Chemically Robust Secondary Amine Tags

Journal of medicinal chemistry, 1996-04, Vol.39 (8), p.1601-1608

1996

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Encoded Combinatorial Chemistry: Synthesis and Screening of a Library of Highly Functionalized Pyrrolidines

Proceedings of the National Academy of Sciences - PNAS, 1997-04, Vol.94 (7), p.2805-2810

1997

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Identification of potent and novel small-molecule inhibitors of caspase-3

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (21), p.3651-3655

2003

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Innovative approaches to novel antibacterial drug discovery

Current opinion in biotechnology, 1997-12, Vol.8 (6), p.757-762

1997

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Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2804-2815

1991

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Hydroxamic Acid-Based Bisubstrate Analog Inhibitors of Ras Farnesyl Protein Transferase

Journal of medicinal chemistry, 1996-10, Vol.39 (21), p.4197-4210

1996

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Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase

Journal of medicinal chemistry, 1988-10, Vol.31 (10), p.1869-1871

1988

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Isoprenyl phosphinylformates: new inhibitors of squalene synthetase

Journal of medicinal chemistry, 1991-06, Vol.34 (6), p.1912-1914

1991

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Isolation and structure elucidation of oxoxylopine, a new oxoaporphine alkaloid from Stephania abyssinica

Journal of organic chemistry, 1970-05, Vol.35 (5), p.1682-1684

1970

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Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells

Oncogene, 1995-05, Vol.10 (9), p.1763-1779

1995

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Combinatorial synthesis and screening of a chemical library of 1,4-dihydropyridine calcium channel blockers

Bioorganic & medicinal chemistry, 1998-07, Vol.6 (7), p.883-889

1998

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Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo

The Journal of biological chemistry, 1993-11, Vol.268 (33), p.24832-24837

1993

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Combinatorial modification of natural products: Preparation of unencoded and encoded libraries of Rauwolfia alkaloids

Bioorganic & medicinal chemistry, 1996-07, Vol.4 (7), p.1097-1106

1996

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Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis

Journal of medicinal chemistry, 1990-11, Vol.33 (11), p.2952-2956

1990

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Prospects for Antibacterial Discovery and Development

In situ assembly of enzyme inhibitors using extended tethering

Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions

Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries

Exercise and rehabilitation of the cancer patient

Combinatorial modification of natural products: Synthesis and in vitro analysis of derivatives of thiazole peptide antibiotic GE2270 A: A-ring modifications

Site-Directed Ligand Discovery

Aminoethylenes: A Tetrahedral Intermediate Isostere Yielding Potent Inhibitors of the Aspartyl Protease BACE-1

Selective Reduction of Peptide Isothiazolidin-3-ones

Farnesyl Diphosphate-Based Inhibitors of Ras Farnesyl Protein Transferase

Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design

Versatile Approach To Encoding Combinatorial Organic Syntheses Using Chemically Robust Secondary Amine Tags

Encoded Combinatorial Chemistry: Synthesis and Screening of a Library of Highly Functionalized Pyrrolidines

Identification of potent and novel small-molecule inhibitors of caspase-3

Innovative approaches to novel antibacterial drug discovery

Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety

Hydroxamic Acid-Based Bisubstrate Analog Inhibitors of Ras Farnesyl Protein Transferase

Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase

Isoprenyl phosphinylformates: new inhibitors of squalene synthetase

Isolation and structure elucidation of oxoxylopine, a new oxoaporphine alkaloid from Stephania abyssinica

Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells

Combinatorial synthesis and screening of a chemical library of 1,4-dihydropyridine calcium channel blockers

Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo

Combinatorial modification of natural products: Preparation of unencoded and encoded libraries of Rauwolfia alkaloids

Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis

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