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High‐Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates

Angewandte Chemie International Edition, 2019-12, Vol.58 (51), p.18405-18409

International ed. in English, 2019

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Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors

Journal of medicinal chemistry, 2018-12, Vol.61 (23), p.10665-10699

2018

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Design considerations for chiral frustrated Lewis pairs: B/N FLPs derived from 3,5-bicyclic aryl piperidines

Dalton transactions : an international journal of inorganic chemistry, 2019, Vol.48 (1), p.133-141

2019

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Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice

PloS one, 2013-10, Vol.8 (10), p.e76557

2013

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Direct activation of relatively unstrained carbon-carbon bonds in homogeneous systems

Org. Chem. Front, 2014-07, Vol.1 (5), p.567-581

2014

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Access to Highly Substituted 7‑Azaindoles from 2‑Fluoropyridines via 7‑Azaindoline Intermediates

Organic letters, 2015-09, Vol.17 (17), p.4292-4295

2015

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High‐Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates

Angewandte Chemie, 2019-12, Vol.131 (51), p.18576-18580

2019

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Structural and Rate Studies of the Formation of Substituted Benzynes

Journal of the American Chemical Society, 2008-03, Vol.130 (11), p.3406-3412

2008

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Rationale, pharmacology and clinical efficacy of partial agonists of α4β2 nACh receptors for smoking cessation

Trends in pharmacological sciences (Regular ed.), 2007-07, Vol.28 (7), p.316-325

2007

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Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin

Journal of medicinal chemistry, 2017-01, Vol.60 (2), p.767-786

2017

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Formation of 3-Halobenzyne: Solvent Effects and Cycloaddition Adducts

Organic letters, 2004-05, Vol.6 (10), p.1589-1592

2004

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Access to 7β-analogs of codeine with mixed μ/δ agonist activity via 6,7-α-epoxide opening

Bioorganic & medicinal chemistry letters, 2013-09, Vol.23 (17), p.4870-4874

2013

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Partial Agonists of the α3β4 Neuronal Nicotinic Acetylcholine Receptor Reduce Ethanol Consumption and Seeking in Rats

Neuropsychopharmacology (New York, N.Y.), 2011-02, Vol.36 (3), p.603-615

2011

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Development of a Scalable Synthesis for an Inhaled pan-JAK Inhibitor

Organic process research & development, 2019-09, Vol.23 (9), p.1990-2000

2019

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Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect

European journal of pharmacology, 2009-03, Vol.605 (1), p.114-116

2009

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METABOLISM AND DISPOSITION OF VARENICLINE, A SELECTIVE α4β2 ACETYLCHOLINE RECEPTOR PARTIAL AGONIST, IN VIVO AND IN VITRO

Drug metabolism and disposition, 2006-01, Vol.34 (1), p.121-130

2006

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Kiloscale Buchwald–Hartwig Amination: Optimized Coupling of Base-Sensitive 6‑Bromoisoquinoline-1-carbonitrile with (S)‑3-Amino-2-methylpropan-1-ol

Organic process research & development, 2014-12, Vol.18 (12), p.1752-1758

2014

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α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties

Behavioural pharmacology, 2011-08, Vol.22 (4), p.291-299

2011

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Total Synthesis of (±)-Cytisine via the Intramolecular Heck Cyclization of Activated N-Alkyl Glutarimides

Organic letters, 2000-12, Vol.2 (26), p.4205-4208

Coe, Jotham W

2000

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Syntheses of the opioid substructures 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine and 2,3,4,5-tetrahydro-1,5-methano-1H-2-benzazepine

Tetrahedron letters, 2011-03, Vol.52 (9), p.953-954

2011

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In pursuit of α4β2 nicotinic receptor partial agonists for smoking cessation: Carbon analogs of (−)-cytisine

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (12), p.2974-2979

2005

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Cyclopentadiene: The Impact of Storage Conditions on Thermal Stability

Organic process research & development, 2007-11, Vol.11 (6), p.1141-1146

2007

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3,5-Bicyclic aryl piperidines: A novel class of α4β2 neuronal nicotinic receptor partial agonists for smoking cessation

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (22), p.4889-4897

2005

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A novel series of [3.2.1] azabicyclic biaryl ethers as α3β4 and α6/4β4 nicotinic receptor agonists

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (16), p.4749-4752

2010

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High‐Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates

Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors

Design considerations for chiral frustrated Lewis pairs: B/N FLPs derived from 3,5-bicyclic aryl piperidines

Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice

Direct activation of relatively unstrained carbon-carbon bonds in homogeneous systems

Access to Highly Substituted 7‑Azaindoles from 2‑Fluoropyridines via 7‑Azaindoline Intermediates

High‐Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates

Structural and Rate Studies of the Formation of Substituted Benzynes

Rationale, pharmacology and clinical efficacy of partial agonists of α4β2 nACh receptors for smoking cessation

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin

Formation of 3-Halobenzyne: Solvent Effects and Cycloaddition Adducts

Access to 7β-analogs of codeine with mixed μ/δ agonist activity via 6,7-α-epoxide opening

Partial Agonists of the α3β4 Neuronal Nicotinic Acetylcholine Receptor Reduce Ethanol Consumption and Seeking in Rats

Development of a Scalable Synthesis for an Inhaled pan-JAK Inhibitor

Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect

METABOLISM AND DISPOSITION OF VARENICLINE, A SELECTIVE α4β2 ACETYLCHOLINE RECEPTOR PARTIAL AGONIST, IN VIVO AND IN VITRO

Kiloscale Buchwald–Hartwig Amination: Optimized Coupling of Base-Sensitive 6‑Bromoisoquinoline-1-carbonitrile with (S)‑3-Amino-2-methylpropan-1-ol

Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models

α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties

Total Synthesis of (±)-Cytisine via the Intramolecular Heck Cyclization of Activated N-Alkyl Glutarimides

Syntheses of the opioid substructures 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine and 2,3,4,5-tetrahydro-1,5-methano-1H-2-benzazepine

In pursuit of α4β2 nicotinic receptor partial agonists for smoking cessation: Carbon analogs of (−)-cytisine

Cyclopentadiene: The Impact of Storage Conditions on Thermal Stability

3,5-Bicyclic aryl piperidines: A novel class of α4β2 neuronal nicotinic receptor partial agonists for smoking cessation

A novel series of [3.2.1] azabicyclic biaryl ethers as α3β4 and α6/4β4 nicotinic receptor agonists

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