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DOT1L Mediated Gene Repression in Extensively Self-Renewing Erythroblasts

Frontiers in genetics, 2022-03, Vol.13, p.828086

2022

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Primitive Erythropoiesis in the Mouse is Independent of DOT1L Methyltransferase Activity

Frontiers in cell and developmental biology, 2022-01, Vol.9, p.813503-813503

2022

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MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape

Molecular cell, 2022-03, Vol.82 (6), p.1140-1155.e11

2022

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Targeted Therapies for Pediatric AML: Gaps and Perspective

Frontiers in pediatrics, 2019-11, Vol.7, p.463-463

2019

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Repurposing epigenetic inhibitors to target the Clostridioides difficile-specific DNA adenine methyltransferase and sporulation regulator CamA

Epigenetics, 2022-09, Vol.17 (9), p.970-981

2022

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Design, synthesis, and biological evaluation of adenosine derivatives targeting DOT1L and HAT as anti-leukemia agents

Bioorganic chemistry, 2024-12, Vol.153, p.107771, Article 107771

2024

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Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome

Molecular cell, 2019-01, Vol.73 (1), p.61-72.e3

2019

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Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity

Bioorganic & medicinal chemistry, 2021-04, Vol.35, p.116072-116072, Article 116072

2021

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DOT1L complex regulates transcriptional initiation in human erythroleukemic cells

Proceedings of the National Academy of Sciences - PNAS, 2021-07, Vol.118 (27), p.1-10

2021

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Neointima abating and endothelium preserving — An adventitia-localized nanoformulation to inhibit the epigenetic writer DOT1L

Biomaterials, 2023-10, Vol.301, p.122245-122245, Article 122245

2023

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Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival

Theranostics, 2018-01, Vol.8 (16), p.4359-4371

2018

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Convenient preparation of pinometostat and related 5′-deoxy-5′-amino adenosine derivatives as well as their activity against DOT1L

Tetrahedron letters, 2018-01, Vol.59 (4), p.415-417

2018

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MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition

Haematologica (Roma), 2015-05, Vol.100 (5), p.e190-e193

2015

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Inhibition of Dot1L Alleviates Fulminant Hepatitis Through Myeloid-Derived Suppressor CellsSummary

Cellular and molecular gastroenterology and hepatology, 2021-01, Vol.12 (1), p.81-98

2021

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New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms

Bioorganic & medicinal chemistry letters, 2016-09, Vol.26 (18), p.4518-4522

2016

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Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects

Epigenetics & chromatin, 2023-12, Vol.16 (1), p.50-50, Article 50

2023

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DOT-1.1 (DOT1L) deficiency in C. elegans leads to small RNA-dependent gene activation

BBA advances, 2023-01, Vol.3, p.100080-100080, Article 100080

2023

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Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors

Bioorganic chemistry, 2018-10, Vol.80, p.649-654

2018

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Preparation of 5′-deoxy-5′-amino-5′-C-methyl adenosine derivatives and their activity against DOT1L

Bioorganic & medicinal chemistry letters, 2017-11, Vol.27 (22), p.4960-4963

2017

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Targeting Histone Methyltransferase DOT1L by a Novel Psammaplin A Analog Inhibits Growth and Metastasis of Triple-Negative Breast Cancer

Molecular therapy. Oncolytics, 2019-12, Vol.15, p.140-152

2019

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Dot1l deficiency leads to increased intercalated cells and upregulation of V-ATPase B1 in mice

Experimental cell research, 2016-06, Vol.344 (2), p.167-175

2016

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Involvement of DOT1L in the Remodeling of Heterochromatin Configuration During Early Preimplantation Development in Mice1

Biology of reproduction, 2013-12, Vol.89 (6)

2013

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Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches

Journal of computer-aided molecular design, 2018-03, Vol.32 (3), p.435-458

2018

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Mechanistic investigations into the species differences in pinometostat clearance: impact of binding to alpha-1-acid glycoprotein and permeability-limited hepatic uptake

Xenobiotica, 2017-03, Vol.47 (3), p.185-193

2017

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Inhibition of Dot1L Alleviates Fulminant Hepatitis Through Myeloid-Derived Suppressor Cells

Cellular and molecular gastroenterology and hepatology, 2021-01, Vol.12 (1), p.81-98

2021

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DOT1L Mediated Gene Repression in Extensively Self-Renewing Erythroblasts

Primitive Erythropoiesis in the Mouse is Independent of DOT1L Methyltransferase Activity

MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape

Targeted Therapies for Pediatric AML: Gaps and Perspective

Repurposing epigenetic inhibitors to target the Clostridioides difficile-specific DNA adenine methyltransferase and sporulation regulator CamA

Design, synthesis, and biological evaluation of adenosine derivatives targeting DOT1L and HAT as anti-leukemia agents

Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome

Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity

DOT1L complex regulates transcriptional initiation in human erythroleukemic cells

Neointima abating and endothelium preserving — An adventitia-localized nanoformulation to inhibit the epigenetic writer DOT1L

Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival

Convenient preparation of pinometostat and related 5′-deoxy-5′-amino adenosine derivatives as well as their activity against DOT1L

MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition

Inhibition of Dot1L Alleviates Fulminant Hepatitis Through Myeloid-Derived Suppressor CellsSummary

New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms

Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects

DOT-1.1 (DOT1L) deficiency in C. elegans leads to small RNA-dependent gene activation

Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors

Preparation of 5′-deoxy-5′-amino-5′-C-methyl adenosine derivatives and their activity against DOT1L

Targeting Histone Methyltransferase DOT1L by a Novel Psammaplin A Analog Inhibits Growth and Metastasis of Triple-Negative Breast Cancer

Dot1l deficiency leads to increased intercalated cells and upregulation of V-ATPase B1 in mice

Involvement of DOT1L in the Remodeling of Heterochromatin Configuration During Early Preimplantation Development in Mice1

Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches

Mechanistic investigations into the species differences in pinometostat clearance: impact of binding to alpha-1-acid glycoprotein and permeability-limited hepatic uptake

Inhibition of Dot1L Alleviates Fulminant Hepatitis Through Myeloid-Derived Suppressor Cells

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