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Increase of Ceramide and Induction of Mixed Apoptosis/Necrosis by N-(4-Hydroxyphenyl)- retinamide in Neuroblastoma Cell Lines

JNCI : Journal of the National Cancer Institute, 1999-07, Vol.91 (13), p.1138-1146

1999

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Targeting Ceramide Metabolism—a Strategy for Overcoming Drug Resistance

JNCI : Journal of the National Cancer Institute, 2001-03, Vol.93 (5), p.347-357

2001

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Modification of ceramide metabolism increases cancer cell sensitivity to cytotoxics

International journal of oncology, 1999-09, Vol.15 (3), p.541

1999

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SDZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drug-resistant cancer cells

Cancer research (Chicago, Ill.), 1999-02, Vol.59 (4), p.880-885

1999

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Glucosylceramide: a marker for multiple-drug resistant cancers

Anticancer research, 1998-01, Vol.18 (1B), p.475

1998

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Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug‐resistant cancer cells

Cancer, 1999-07, Vol.86 (2), p.300-311

1999

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Ceramide glycosylation potentiates cellular multidrug resistance

The FASEB journal, 2001-03, Vol.15 (3), p.719-730

2001

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Synergistic Cytotoxicity in Solid Tumor Cell Lines Between N-(4-Hydroxyphenyl)retinamide and Modulators of Ceramide Metabolism

JNCI : Journal of the National Cancer Institute, 2000-12, Vol.92 (23), p.1897-1909

2000

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Ceramide toxicity and metabolism differ in wild-type and multidrug-resistant cancer cells

International journal of oncology, 1999-09, Vol.15 (3), p.535

1999

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Expression of Glucosylceramide Synthase, Converting Ceramide to Glucosylceramide, Confers Adriamycin Resistance in Human Breast Cancer Cells

The Journal of biological chemistry, 1999-01, Vol.274 (2), p.1140-1146

1999

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N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase

Cancer research (Chicago, Ill.), 2001-07, Vol.61 (13), p.5102-5105

2001

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SDZ PSC 833 the drug resistance modulator activates cellular ceramide formation by a pathway independent of P-glycoprotein

Cancer letters, 2000-02, Vol.149 (1), p.143-151

2000

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Accumulation of Glucosylceramides in Multidrug-resistant Cancer Cells

The Journal of biological chemistry, 1996-08, Vol.271 (32), p.19530-19536

1996

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Tamoxifen induces selective membrane association of protein kinase C epsilon in MCF‐7 human breast cancer cells

International journal of cancer, 1998-09, Vol.77 (6), p.928-932

1998

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Agents that Reverse Multidrug Resistance, Tamoxifen, Verapamil, and Cyclosporin A, Block Glycosphingolipid Metabolism by Inhibiting Ceramide Glycosylation in Human Cancer Cells

The Journal of biological chemistry, 1997-01, Vol.272 (3), p.1682-1687

1997

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Identification of phosphatidylcholine-selective and phosphatidylinositol-selective phospholipases D in Madin-Darby canine kidney cells

The Journal of biological chemistry, 1992-08, Vol.267 (24), p.16859-16865

1992

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Tamoxifen activates cellular phospholipase C and D and elicits protein kinase C translocation

International journal of cancer, 1997-03, Vol.70 (5), p.567-574

1997

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Vasopressin-induced polyphosphoinositide and phosphatidylcholine degradation in fibroblasts. Temporal relationship for formation of phospholipase C and phospholipase D hydrolysis products

The Journal of biological chemistry, 1990-10, Vol.265 (29), p.17468-17473

1990

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Uncoupling Ceramide Glycosylation by Transfection of Glucosylceramide Synthase Antisense Reverses Adriamycin Resistance

The Journal of biological chemistry, 2000-03, Vol.275 (10), p.7138-7143

2000

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Taxol-induced ceramide generation and apoptosis in human breast cancer cells

Cancer chemotherapy and pharmacology, 2001-05, Vol.47 (5), p.444-450

2001

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Lipid signal transduction pathways in angiotensin II type 1 receptor-transfected fibroblasts

American Journal of Physiology: Cell Physiology, 1995-08, Vol.269 (2), p.C435-C442

1995

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Glycosylation of Ceramide Potentiates Cellular Resistance to Tumor Necrosis Factor-α-Induced Apoptosis

Experimental cell research, 1999-11, Vol.252 (2), p.464-470

1999

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The antitumor phospholipid analog, hexadecylphosphocholine, activates cellular phospholipase D

Cancer letters, 1996-02, Vol.100 (1), p.71-79

1996

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The multidrug resistance modulator SDZ PSC 833 is a potent activator of cellular ceramide formation

FEBS letters, 1998-07, Vol.431 (2), p.185-188

1998

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Phorbol diesters stimulate the accumulation of phosphatidate, phosphatidylethanol, and diacylglycerol in three cell types. Evidence for the indirect formation of phosphatidylcholine-derived diacylglycerol by a phospholipase D pathway and direct formation of diacylglycerol by a phospholipase C pathway

The Journal of biological chemistry, 1990-09, Vol.265 (25), p.14858-14863

1990

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Increase of Ceramide and Induction of Mixed Apoptosis/Necrosis by N-(4-Hydroxyphenyl)- retinamide in Neuroblastoma Cell Lines

Targeting Ceramide Metabolism—a Strategy for Overcoming Drug Resistance

Modification of ceramide metabolism increases cancer cell sensitivity to cytotoxics

SDZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drug-resistant cancer cells

Glucosylceramide: a marker for multiple-drug resistant cancers

Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug‐resistant cancer cells

Ceramide glycosylation potentiates cellular multidrug resistance

Synergistic Cytotoxicity in Solid Tumor Cell Lines Between N-(4-Hydroxyphenyl)retinamide and Modulators of Ceramide Metabolism

Ceramide toxicity and metabolism differ in wild-type and multidrug-resistant cancer cells

Expression of Glucosylceramide Synthase, Converting Ceramide to Glucosylceramide, Confers Adriamycin Resistance in Human Breast Cancer Cells

N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase

SDZ PSC 833 the drug resistance modulator activates cellular ceramide formation by a pathway independent of P-glycoprotein

Accumulation of Glucosylceramides in Multidrug-resistant Cancer Cells

Tamoxifen induces selective membrane association of protein kinase C epsilon in MCF‐7 human breast cancer cells

Agents that Reverse Multidrug Resistance, Tamoxifen, Verapamil, and Cyclosporin A, Block Glycosphingolipid Metabolism by Inhibiting Ceramide Glycosylation in Human Cancer Cells

Identification of phosphatidylcholine-selective and phosphatidylinositol-selective phospholipases D in Madin-Darby canine kidney cells

Tamoxifen activates cellular phospholipase C and D and elicits protein kinase C translocation

Vasopressin-induced polyphosphoinositide and phosphatidylcholine degradation in fibroblasts. Temporal relationship for formation of phospholipase C and phospholipase D hydrolysis products

Uncoupling Ceramide Glycosylation by Transfection of Glucosylceramide Synthase Antisense Reverses Adriamycin Resistance

Taxol-induced ceramide generation and apoptosis in human breast cancer cells

Lipid signal transduction pathways in angiotensin II type 1 receptor-transfected fibroblasts

Glycosylation of Ceramide Potentiates Cellular Resistance to Tumor Necrosis Factor-α-Induced Apoptosis

The antitumor phospholipid analog, hexadecylphosphocholine, activates cellular phospholipase D

The multidrug resistance modulator SDZ PSC 833 is a potent activator of cellular ceramide formation

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