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Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

PLoS medicine, 2016-10, Vol.13 (10), p.e1002139

2016

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Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes

PloS one, 2014-02, Vol.9 (2), p.e89561-e89561

2014

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A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease

Journal of autoimmunity, 2018-12, Vol.95, p.1-14

2018

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Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

Genome medicine, 2020-06, Vol.12 (1), p.55-55, Article 55

2020

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Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases

Nature communications, 2019-07, Vol.10 (1), p.3216-15, Article 3216

2019

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Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping

PLoS genetics, 2015-06, Vol.11 (6), p.e1005272-e1005272

2015

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Chromosome contacts in activated T cells identify autoimmune disease candidate genes

Genome Biology, 2017-09, Vol.18 (1), p.165-165, Article 165

2017

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SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile

Genome medicine, 2023-09, Vol.15 (1), p.1-69, Article 69

2023

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Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice

PLoS genetics, 2019-06, Vol.15 (6), p.e1008178-e1008178

2019

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Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes

Nature genetics, 2007-09, Vol.39 (9), p.1074-1082

2007

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PTPN22 alters the development of regulatory T cells in the thymus

The Journal of immunology (1950), 2012-06, Vol.188 (11), p.5267-5275

2012

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Low-dose IL-2 reduces IL-21 + T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes

Nature communications, 2022-11, Vol.13 (1), p.7324-7324, Article 7324

2022

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The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus

Arthritis research & therapy, 2018-07, Vol.20 (1), p.152-152, Article 152

2018

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The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults

Diabetologia, 2024-06, Vol.67 (6), p.995-1008

2024

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Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

Journal of autoimmunity, 2017-11, Vol.84, p.75-86

2017

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Circulating C-Peptide Levels in Living Children and Young People and Pancreatic Beta Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration

Diabetes (New York, N.Y.), 2022-07, Vol.71 (7), p.1591-1596

2022

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Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells

Nature communications, 2023-04, Vol.14 (1), p.2071-2071, Article 2071

2023

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Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

Nature genetics, 2009-09, Vol.41 (9), p.1011-1015

2009

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Liver autoimmunity triggered by microbial activation of natural killer T cells

Cell host & microbe, 2008-05, Vol.3 (5), p.304-315

2008

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Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells

Journal of autoimmunity, 2015-01, Vol.56, p.66-80

2015

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Genetic Protection from the Inflammatory Disease Type 1 Diabetes in Humans and Animal Models

Immunity, 2001-09, Vol.15 (3), p.387-395

2001

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In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes

Nature genetics, 2006-04, Vol.38 (4), p.479-483

2006

Volltextzugriff (PDF)

Genetic susceptibility to type 1 diabetes

Current Opinion in Immunology, 2005-12, Vol.17 (6), p.601-608

2005

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Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles

The Journal of immunology (1950), 2014-07, Vol.193 (2), p.889-900

2014

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Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes

A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile

Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes

PTPN22 alters the development of regulatory T cells in the thymus

Low-dose IL-2 reduces IL-21 + T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes

The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus

The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

Circulating C-Peptide Levels in Living Children and Young People and Pancreatic Beta Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

Liver autoimmunity triggered by microbial activation of natural killer T cells

Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells

Genetic Protection from the Inflammatory Disease Type 1 Diabetes in Humans and Animal Models

In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes

Genetic susceptibility to type 1 diabetes

Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles

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