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CYP induction-mediated drug interactions: in vitro assessment and clinical implications

Pharmaceutical research, 2006-06, Vol.23 (6), p.1089-1116

Lin, Jiunn H

2006

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Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites

The Journal of pharmacology and experimental therapeutics, 2002-02, Vol.300 (2), p.549

2002

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Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein

The Journal of pharmacology and experimental therapeutics, 2009-11, Vol.331 (2), p.392

2009

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Possible mechanisms of thyroid hormone disruption in mice by BDE 47, a major polybrominated diphenyl ether congener

Toxicology and applied pharmacology, 2008-02, Vol.226 (3), p.244-250

2008

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Role for mitogen-activated protein kinases in phenobarbital-induced expression of cytochrome P450 2B in primary cultures of rat hepatocytes

Toxicology letters, 2006-02, Vol.161 (1), p.61-72

2006

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Impacts of Blast-Induced Traumatic Brain Injury on Expressions of Hepatic Cytochrome P450 1A2, 2B1, 2D1, and 3A2 in Rats

Cellular and molecular neurobiology, 2017-01, Vol.37 (1), p.111-120

2017

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CAR expression and inducibility of CYP2B genes in liver of rats treated with PB-like inducers

Toxicology (Amsterdam), 2005-12, Vol.216 (2), p.147-153

2005

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Reduction of thyroid hormones triggers down-regulation of hepatic CYP2B through nuclear receptors CAR and TR in a rat model of acute stroke

Biochemical pharmacology, 2014-02, Vol.87 (4), p.636-649

2014

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Higher gene expression of CYP1A2, 2B1 and 2D2 in the brain of female compared with male rats

Pharmazie, 2016-06, Vol.71 (6), p.334-336

2016

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Pressure prods an elusive superconductor to emerge at last

Nature (London), 2022-05, Vol.605 (7908), p.10-10

2022

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Toxicological Consequences of Differential Regulation of Cytochrome P450 Isoforms in Rat Brain Regions by Phenobarbital

Archives of biochemistry and biophysics, 2002-03, Vol.399 (1), p.56-65

2002

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Effect of Conformational Dynamics on Substrate Recognition and Specificity as Probed by the Introduction of a de Novo Disulfide Bond into Cytochrome P450 2B1

The Journal of biological chemistry, 2009-09, Vol.284 (38), p.25678-25686

2009

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Cytochrome P450 gene induction in rats ex vivo assessed by quantitative real-time reverse transcriptase-polymerase chain reaction (TaqMan)

Drug metabolism and disposition, 2006-06, Vol.34 (6), p.1063

2006

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N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: Effects of cytochrome P450 induction by phenobarbital

Toxicology letters, 2011-10, Vol.206 (2), p.139-143

2011

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Cytochrome-P450 2B1 gene silencing attenuates puromycin aminonucleoside-induced cytotoxicity in glomerular epithelial cells

Kidney international, 2010-07, Vol.78 (2), p.182-190

2010

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Covalent modification of Thr302 in cytochrome P450 2B1 by the mechanism-based inactivator 4-tert-butylphenylacetylene

The Journal of pharmacology and experimental therapeutics, 2010-06, Vol.333 (3), p.663

2010

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Green tea extract increases cyclophosphamide-induced teratogenesis by modulating the expression of cytochrome P-450 mRNA

Reproductive toxicology (Elmsford, N.Y.), 2009, Vol.27 (1), p.79-84

2009

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Role of the Alanine at Position 363 of Cytochrome P450 2B2 in Influencing the NADPH- and Hydroperoxide-Supported Activities

Archives of biochemistry and biophysics, 1998-02, Vol.350 (2), p.324-332

1998

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Expression and localization of the CYP2B subfamily predominantly in neurones of rat brain

Journal of neurochemistry, 2001-01, Vol.76 (2), p.332-340

2001

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Orphan Receptor Promiscuity in the Induction of Cytochromes P450 by Xenobiotics

The Journal of biological chemistry, 2001-04, Vol.276 (16), p.12822-12826

2001

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Piperine inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in V79 Chinese hamster cells genetically engineered to express rat cytochrome P4502B1

Journal of ethnopharmacology, 1997-11, Vol.58 (3), p.165-173

1997

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Induction of cytochromes P450 in small intestine by chemopreventive compounds

Neuro-endocrinology letters, 2008-10, Vol.29 (5), p.717

2008

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A Rational Approach to Re-engineer Cytochrome P450 2B1 Regioselectivity Based on the Crystal Structure of Cytochrome P450 2C5

The Journal of biological chemistry, 2003-05, Vol.278 (19), p.17178-17184

2003

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Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1

Biochemical journal, 2001-04, Vol.355 (Pt 1), p.71-78

2001

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Repression of Phenobarbital-Dependent CYP2B1 mRNA Induction by Reactive Oxygen Species in Primary Rat Hepatocyte Cultures

Molecular pharmacology, 2001-06, Vol.59 (6), p.1402-1409

2001

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CYP induction-mediated drug interactions: in vitro assessment and clinical implications

Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites

Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein

Possible mechanisms of thyroid hormone disruption in mice by BDE 47, a major polybrominated diphenyl ether congener

Role for mitogen-activated protein kinases in phenobarbital-induced expression of cytochrome P450 2B in primary cultures of rat hepatocytes

Impacts of Blast-Induced Traumatic Brain Injury on Expressions of Hepatic Cytochrome P450 1A2, 2B1, 2D1, and 3A2 in Rats

CAR expression and inducibility of CYP2B genes in liver of rats treated with PB-like inducers

Reduction of thyroid hormones triggers down-regulation of hepatic CYP2B through nuclear receptors CAR and TR in a rat model of acute stroke

Higher gene expression of CYP1A2, 2B1 and 2D2 in the brain of female compared with male rats

Pressure prods an elusive superconductor to emerge at last

Toxicological Consequences of Differential Regulation of Cytochrome P450 Isoforms in Rat Brain Regions by Phenobarbital

Effect of Conformational Dynamics on Substrate Recognition and Specificity as Probed by the Introduction of a de Novo Disulfide Bond into Cytochrome P450 2B1

Cytochrome P450 gene induction in rats ex vivo assessed by quantitative real-time reverse transcriptase-polymerase chain reaction (TaqMan)

N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: Effects of cytochrome P450 induction by phenobarbital

Cytochrome-P450 2B1 gene silencing attenuates puromycin aminonucleoside-induced cytotoxicity in glomerular epithelial cells

Covalent modification of Thr302 in cytochrome P450 2B1 by the mechanism-based inactivator 4-tert-butylphenylacetylene

Green tea extract increases cyclophosphamide-induced teratogenesis by modulating the expression of cytochrome P-450 mRNA

Role of the Alanine at Position 363 of Cytochrome P450 2B2 in Influencing the NADPH- and Hydroperoxide-Supported Activities

Expression and localization of the CYP2B subfamily predominantly in neurones of rat brain

Orphan Receptor Promiscuity in the Induction of Cytochromes P450 by Xenobiotics

Piperine inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in V79 Chinese hamster cells genetically engineered to express rat cytochrome P4502B1

Induction of cytochromes P450 in small intestine by chemopreventive compounds

A Rational Approach to Re-engineer Cytochrome P450 2B1 Regioselectivity Based on the Crystal Structure of Cytochrome P450 2C5

Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1

Repression of Phenobarbital-Dependent CYP2B1 mRNA Induction by Reactive Oxygen Species in Primary Rat Hepatocyte Cultures

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