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Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1673-1693

2014

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In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

Antimicrobial Agents and Chemotherapy, 2009-04, Vol.53 (4), p.1377-1385

2009

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Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts

Bone (New York, N.Y.), 2008-01, Vol.42 (1), p.200-211

2008

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Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

Bioorganic & medicinal chemistry, 2008-09, Vol.18 (17), p.4853-4858

2008

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Relationships between Structure and Interaction Kinetics for HIV-1 Protease Inhibitors

Journal of medicinal chemistry, 2002-12, Vol.45 (25), p.5430-5439

2002

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Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-Length NS3 (Protease-Helicase/NTPase): A comparative study of different C-terminals

Bioorganic & medicinal chemistry, 2003-06, Vol.11 (12), p.2551-2568

2003

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Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (1), p.310-317

2013

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Plasmepsins as potential targets for new antimalarial therapy

Medicinal research reviews, 2006-09, Vol.26 (5), p.626-666

2006

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Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Antimicrobial Agents and Chemotherapy, 2011-08, Vol.55 (8), p.3812-3820

2011

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Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II

Bioorganic & medicinal chemistry, 2005-09, Vol.13 (18), p.5371-5390

2005

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Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: Exploration of P2 quinazoline substituents

Bioorganic & medicinal chemistry letters, 2010-07, Vol.20 (14), p.4004-4011

2010

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Erratum to ‘Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts’

Bone (New York, N.Y.), 2021-04, Vol.145, p.115354-115354, Article 115354

2021

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A novel assay for analysis of the regulation of the function of human osteoclasts

Journal of translational medicine, 2006-11, Vol.4 (1), p.45-45, Article 45

2006

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Nucleotide Prodrugs of 2′-Deoxy-2′-spirooxetane Ribonucleosides as Novel Inhibitors of the HCV NS5B Polymerase

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1836-1844

2014

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Impact of the Central Hydroxyl Groups on the Activity of Symmetrical HIV-1 Protease Inhibitors Derived From l-Mannaric Acid

Tetrahedron, 2000-05, Vol.56 (20), p.3219-3225

2000

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A One-Pot, Solid-Phase Synthesis of Secondary Amines from Reactive Alkyl Halides and an Alkyl Azide

Synlett, 2008-01, Vol.2008 (1), p.97-99

2008

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Synthesis of carbocyclic 2′3′-dideoxy-2′-fluoro-3′-C-hydroxymethyl nucleoside analogues as potential inhibitors of HIV and HSV

Tetrahedron, 1997-02, Vol.53 (5), p.1861-1872

1997

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2′-Deoxy-2′-spirocyclopropylcytidine Revisited: A New and Selective Inhibitor of the Hepatitis C Virus NS5B Polymerase

Journal of medicinal chemistry, 2010-11, Vol.53 (22), p.8150-8160

2010

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Potent Inhibitors of the Plasmodium falciparum Enzymes Plasmepsin I and II Devoid of Cathepsin D Inhibitory Activity

Journal of medicinal chemistry, 2004-01, Vol.47 (1), p.110-122

2004

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Synthesis of [4,5-Bis(hydroxymethyl)-1,3-dioxolan-2-yl]nucleosides as Potential Inhibitors of HIV

Journal of organic chemistry, 1996-05, Vol.61 (11), p.3599-3603

1996

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Synthesis of a small library of non-symmetric cyclic sulfamide HIV-1 protease inhibitors

Tetrahedron, 2010-06, Vol.66 (23), p.4049-4056

2010

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Asymmetric Synthesis of α- and β-Benzylhydroxy-γ-butyrolactones

Synlett, 2010-01, Vol.2010 (1), p.131-133

2010

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Design and synthesis of novel P2 substituents in diol-based HIV protease inhibitors

European journal of medicinal chemistry, 2010, Vol.45 (1), p.160-170

2010

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Synthesis of Malarial Plasmepsin Inhibitors and Prediction of Binding Modes by Molecular Dynamics Simulations

Journal of medicinal chemistry, 2005-09, Vol.48 (19), p.6090-6106

2005

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Design and Synthesis of Plasmepsin I and Plasmepsin II Inhibitors with Activity in Plasmodium falciparum-Infected Cultured Human Erythrocytes

Journal of medicinal chemistry, 2003-02, Vol.46 (5), p.734-746

2003

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Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor

In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts

Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

Relationships between Structure and Interaction Kinetics for HIV-1 Protease Inhibitors

Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-Length NS3 (Protease-Helicase/NTPase): A comparative study of different C-terminals

Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application

Plasmepsins as potential targets for new antimalarial therapy

Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II

Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: Exploration of P2 quinazoline substituents

Erratum to ‘Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts’

A novel assay for analysis of the regulation of the function of human osteoclasts

Nucleotide Prodrugs of 2′-Deoxy-2′-spirooxetane Ribonucleosides as Novel Inhibitors of the HCV NS5B Polymerase

Impact of the Central Hydroxyl Groups on the Activity of Symmetrical HIV-1 Protease Inhibitors Derived From l-Mannaric Acid

A One-Pot, Solid-Phase Synthesis of Secondary Amines from Reactive Alkyl Halides and an Alkyl Azide

Synthesis of carbocyclic 2′3′-dideoxy-2′-fluoro-3′-C-hydroxymethyl nucleoside analogues as potential inhibitors of HIV and HSV

2′-Deoxy-2′-spirocyclopropylcytidine Revisited: A New and Selective Inhibitor of the Hepatitis C Virus NS5B Polymerase

Potent Inhibitors of the Plasmodium falciparum Enzymes Plasmepsin I and II Devoid of Cathepsin D Inhibitory Activity

Synthesis of [4,5-Bis(hydroxymethyl)-1,3-dioxolan-2-yl]nucleosides as Potential Inhibitors of HIV

Synthesis of a small library of non-symmetric cyclic sulfamide HIV-1 protease inhibitors

Asymmetric Synthesis of α- and β-Benzylhydroxy-γ-butyrolactones

Design and synthesis of novel P2 substituents in diol-based HIV protease inhibitors

Synthesis of Malarial Plasmepsin Inhibitors and Prediction of Binding Modes by Molecular Dynamics Simulations

Design and Synthesis of Plasmepsin I and Plasmepsin II Inhibitors with Activity in Plasmodium falciparum-Infected Cultured Human Erythrocytes

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