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Role of reactive metabolites in the circulation in extrahepatic toxicity

Expert opinion on drug metabolism & toxicology, 2012-09, Vol.8 (9), p.1157-1172

2012

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Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties

Expert opinion on drug metabolism & toxicology, 2017-05, Vol.13 (5), p.513-524

2017

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Gender differences in methionine accumulation and metabolism in freshly isolated mouse hepatocytes: Potential roles in toxicity

Toxicology and applied pharmacology, 2009-05, Vol.236 (3), p.358-365

2009

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Mercapturic Acid Urinary Metabolites of 3-Butene-1,2-diol as in Vivo Evidence for the Formation of Hydroxymethylvinyl Ketone in Mice and Rats

Chemical research in toxicology, 2004-06, Vol.17 (6), p.819-826

2004

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Hydroxymethylvinyl Ketone: A Reactive Michael Acceptor Formed by the Oxidation of 3-Butene-1,2-diol by cDNA-Expressed Human Cytochrome P450s and Mouse, Rat, and Human Liver Microsomes

Chemical research in toxicology, 2001-12, Vol.14 (12), p.1590-1595

2001

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Mutagenicity of the cysteine S -conjugate sulfoxides of trichloroethylene and tetrachloroethylene in the Ames test

Toxicology (Amsterdam), 2013-04, Vol.306, p.157-161

2013

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Characterization of the Reaction Products of 2‘-Deoxyguanosine and 1,2,3,4-Diepoxybutane after Acid Hydrolysis: Formation of Novel Guanine and Pyrimidine Adducts

Chemical research in toxicology, 2004-04, Vol.17 (4), p.521-528

2004

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Alcohol Dehydrogenase- and Rat Liver Cytosol-Dependent Bioactivation of 1‑Chloro-2-hydroxy-3-butene to 1‑Chloro-3-buten-2-one, a Bifunctional Alkylating Agent

Chemical research in toxicology, 2012-11, Vol.25 (11), p.2600-2607

2012

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Identification of a Fused-Ring 2′-Deoxyadenosine Adduct Formed in Human Cells Incubated with 1‑Chloro-3-buten-2-one, a Potential Reactive Metabolite of 1,3-Butadiene

Chemical research in toxicology, 2016-06, Vol.29 (6), p.1041-1050

2016

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Glutathione-dependent metabolism of trichloroethylene in isolated liver and kidney cells of rats and its role in mitochondrial and cellular toxicity

Drug metabolism and disposition, 1995-08, Vol.23 (8), p.846

1995

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Novel adducts from the reaction of 1-chloro-3-buten-2-one with 2′-deoxyguanosine. Structural characterization and potential as tools to investigate 1,3-butadiene carcinogenicity

Chemico-biological interactions, 2015-01, Vol.226, p.40-48

2015

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The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance

Expert opinion on drug metabolism & toxicology, 2010-11, Vol.6 (11), p.1333-1346

2010

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Glutathione conjugation of trichloroethylene in rats and mice: sex-, species-, and tissue-dependent differences

Drug metabolism and disposition, 1998-01, Vol.26 (1), p.12

1998

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Renal Toxicity of Perchloroethylene and S-(1,2,2-Trichlorovinyl)glutathione in Rats and Mice: Sex- and Species-Dependent Differences

Toxicology and applied pharmacology, 2002-03, Vol.179 (3), p.163-171

2002

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Epoxide hydrolase-dependent metabolism of butadiene monoxide to 3-butene-1,2-diol in mouse, rat, and human liver

Drug metabolism and disposition, 1997-08, Vol.25 (8), p.1013

1997

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A Comprehensive Structural Analysis of Hemoglobin Adducts Formed after in Vitro Exposure of Erythrocytes to Butadiene Monoxide

Chemical research in toxicology, 2000-11, Vol.13 (11), p.1103-1113

2000

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Characterization of the chemical reactivity and nephrotoxicity of N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine sulfoxide, a potential reactive metabolite of trichloroethylene

Toxicology and applied pharmacology, 2013-02, Vol.267 (1), p.1-10

2013

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Formation of Three N-Acetyl-l-cysteine Monoadducts and One Diadduct by the Reaction of S-(1,2-Dichlorovinyl)-l-cysteine Sulfoxide with N-Acetyl-l-cysteine at Physiological Conditions: Chemical Mechanisms and Toxicological Implications

Chemical research in toxicology, 2007-10, Vol.20 (10), p.1563-1569

2007

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Cytotoxicity, genotoxicity, and mutagenicity of 1-chloro-2-hydroxy-3-butene and 1-chloro-3-buten-2-one, two alternative metabolites of 1,3-butadiene

Toxicology and applied pharmacology, 2013-08, Vol.271 (1), p.13-19

2013

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Roles of cysteine conjugate beta-lyase and S-oxidase in nephrotoxicity: studies with S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)-L-cysteine sulfoxide

The Journal of pharmacology and experimental therapeutics, 1994-04, Vol.269 (1), p.374

1994

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Species and Tissue Differences in the Toxicity of 3-Butene-1,2-diol in Male Sprague-Dawley Rats and B6C3F1 Mice

Toxicological sciences, 2004-07, Vol.80 (1), p.3-13

2004

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N-Biotinyl-S-(1,2-dichlorovinyl)-l-cysteine Sulfoxide as a Potential Model for S-(1,2-Dichlorovinyl)-l-cysteine Sulfoxide: Characterization of Stability and Reactivity with Glutathione and Kidney Proteins in Vitro

Chemical research in toxicology, 2011-11, Vol.24 (11), p.1915-1923

2011

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Characterization of N 1- and N 6-Adenosine Adducts and N 1-Inosine Adducts Formed by the Reaction of Butadiene Monoxide with Adenosine: Evidence for the N 1-Adenosine Adducts as Major Initial Products

Chemical research in toxicology, 1996-07, Vol.9 (5), p.875-881

1996

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Biochemistry of 1,3-butadiene metabolism and its relevance to 1,3-butadiene-induced carcinogenicity

Toxicology (Amsterdam), 1996-10, Vol.113 (1), p.23-30

1996

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Cellular and molecular basis for species, sex and tissue differences in 1,3-butadiene metabolism

Chemico-biological interactions, 2001-06, Vol.135, p.239-248

2001

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Role of reactive metabolites in the circulation in extrahepatic toxicity

Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties

Gender differences in methionine accumulation and metabolism in freshly isolated mouse hepatocytes: Potential roles in toxicity

Mercapturic Acid Urinary Metabolites of 3-Butene-1,2-diol as in Vivo Evidence for the Formation of Hydroxymethylvinyl Ketone in Mice and Rats

Hydroxymethylvinyl Ketone: A Reactive Michael Acceptor Formed by the Oxidation of 3-Butene-1,2-diol by cDNA-Expressed Human Cytochrome P450s and Mouse, Rat, and Human Liver Microsomes

Mutagenicity of the cysteine S -conjugate sulfoxides of trichloroethylene and tetrachloroethylene in the Ames test

Characterization of the Reaction Products of 2‘-Deoxyguanosine and 1,2,3,4-Diepoxybutane after Acid Hydrolysis: Formation of Novel Guanine and Pyrimidine Adducts

Alcohol Dehydrogenase- and Rat Liver Cytosol-Dependent Bioactivation of 1‑Chloro-2-hydroxy-3-butene to 1‑Chloro-3-buten-2-one, a Bifunctional Alkylating Agent

Identification of a Fused-Ring 2′-Deoxyadenosine Adduct Formed in Human Cells Incubated with 1‑Chloro-3-buten-2-one, a Potential Reactive Metabolite of 1,3-Butadiene

Glutathione-dependent metabolism of trichloroethylene in isolated liver and kidney cells of rats and its role in mitochondrial and cellular toxicity

Novel adducts from the reaction of 1-chloro-3-buten-2-one with 2′-deoxyguanosine. Structural characterization and potential as tools to investigate 1,3-butadiene carcinogenicity

The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance

Glutathione conjugation of trichloroethylene in rats and mice: sex-, species-, and tissue-dependent differences

Renal Toxicity of Perchloroethylene and S-(1,2,2-Trichlorovinyl)glutathione in Rats and Mice: Sex- and Species-Dependent Differences

Epoxide hydrolase-dependent metabolism of butadiene monoxide to 3-butene-1,2-diol in mouse, rat, and human liver

A Comprehensive Structural Analysis of Hemoglobin Adducts Formed after in Vitro Exposure of Erythrocytes to Butadiene Monoxide

Characterization of the chemical reactivity and nephrotoxicity of N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine sulfoxide, a potential reactive metabolite of trichloroethylene

Formation of Three N-Acetyl-l-cysteine Monoadducts and One Diadduct by the Reaction of S-(1,2-Dichlorovinyl)-l-cysteine Sulfoxide with N-Acetyl-l-cysteine at Physiological Conditions: Chemical Mechanisms and Toxicological Implications

Cytotoxicity, genotoxicity, and mutagenicity of 1-chloro-2-hydroxy-3-butene and 1-chloro-3-buten-2-one, two alternative metabolites of 1,3-butadiene

Roles of cysteine conjugate beta-lyase and S-oxidase in nephrotoxicity: studies with S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)-L-cysteine sulfoxide

Species and Tissue Differences in the Toxicity of 3-Butene-1,2-diol in Male Sprague-Dawley Rats and B6C3F1 Mice

N-Biotinyl-S-(1,2-dichlorovinyl)-l-cysteine Sulfoxide as a Potential Model for S-(1,2-Dichlorovinyl)-l-cysteine Sulfoxide: Characterization of Stability and Reactivity with Glutathione and Kidney Proteins in Vitro

Characterization of N 1- and N 6-Adenosine Adducts and N 1-Inosine Adducts Formed by the Reaction of Butadiene Monoxide with Adenosine: Evidence for the N 1-Adenosine Adducts as Major Initial Products

Biochemistry of 1,3-butadiene metabolism and its relevance to 1,3-butadiene-induced carcinogenicity

Cellular and molecular basis for species, sex and tissue differences in 1,3-butadiene metabolism

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