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Role of reactive metabolites in the circulation in extrahepatic toxicity

Expert opinion on drug metabolism & toxicology, 2012-09, Vol.8 (9), p.1157-1172

2012

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Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes

The Journal of pharmacology and experimental therapeutics, 2009-06, Vol.329 (3), p.1148

2009

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S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant

The Journal of pharmacology and experimental therapeutics, 2007-06, Vol.321 (3), p.1095

2007

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Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences

The Journal of pharmacology and experimental therapeutics, 2001-04, Vol.297 (1), p.155

2001

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Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: evidence for two distinct mechanisms in rats

The Journal of pharmacology and experimental therapeutics, 1999-09, Vol.290 (3), p.950

1999

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Glutathione conjugation of trichloroethylene in rats and mice: sex-, species-, and tissue-dependent differences

Drug metabolism and disposition, 1998-01, Vol.26 (1), p.12

1998

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Flavin-containing monooxygenase (FMO)-dependent metabolism of methionine and evidence for FMO3 being the major FMO involved in methionine sulfoxidation in rabbit liver and kidney microsomes

The Journal of biological chemistry, 1994-07, Vol.269 (26), p.17525-17530

1994

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N-Biotinyl-S-(1,2-dichlorovinyl)-l-cysteine Sulfoxide as a Potential Model for S-(1,2-Dichlorovinyl)-l-cysteine Sulfoxide: Characterization of Stability and Reactivity with Glutathione and Kidney Proteins in Vitro

Chemical research in toxicology, 2011-11, Vol.24 (11), p.1915-1923

2011

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Cellular and molecular basis for species, sex and tissue differences in 1,3-butadiene metabolism

Chemico-biological interactions, 2001-06, Vol.135, p.239-248

2001

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Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity

Biochemical pharmacology, 1986-01, Vol.35 (2), p.283-288

1986

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Renal Cellular Transport, Metabolism, and Cytotoxicity of S-(6-Purinyl)glutathione, a Prodrug of 6-Mercaptopurine, and Analogues

Biochemical pharmacology, 1997-12, Vol.54 (12), p.1341-1349

1997

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Targeting of 6-mercaptopurine to the kidneys. Metabolism and kidney-selectivity of S-(6-purinyl)-L-cysteine analogs in rats

Drug metabolism and disposition, 1993-09, Vol.21 (5), p.841

1993

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Methimazole protection of rats against chemically induced kidney damage in vivo

The Journal of pharmacology and experimental therapeutics, 1992-01, Vol.260 (1), p.393

1992

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Reactivity of cysteine S-conjugate sulfoxides: formation of S-[1-chloro-2-(S-glutathionyl)vinyl]-L-cysteine sulfoxide by the reaction of S-(1,2-dichlorovinyl)-L-cysteine sulfoxide with glutathione

Chemical research in toxicology, 1991-11, Vol.4 (6), p.655-660

1991

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Cysteine S-conjugates may act as kidney-selective prodrugs: formation of 6-mercaptopurine by the renal metabolism of S-(6-purinyl)-L-cysteine

The Journal of pharmacology and experimental therapeutics, 1989-11, Vol.251 (2), p.448

1989

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Alpha-ketoacids stimulate rat renal cysteine conjugate beta-lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine

Molecular pharmacology, 1987-02, Vol.31 (2), p.208-212

1987

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Methimazole as a protectant against cisplatin-induced nephrotoxicity using the dog as a model

Cancer chemotherapy and pharmacology, 1993-01, Vol.33 (1), p.25-30

1993

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S-(1,2-dichlorovinyl)- l-homocysteine-induced cytotoxicity in isolated rat kidney cells

Archives of biochemistry and biophysics, 1986-12, Vol.251 (2), p.432-439

1986

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Nephrotoxic amino acid and glutathione S-conjugates: formation and renal activation

Advances in experimental medicine and biology, 1986, Vol.197, p.443

1986

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Role of reactive metabolites in the circulation in extrahepatic toxicity

Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes

S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant

Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences

Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: evidence for two distinct mechanisms in rats

Glutathione conjugation of trichloroethylene in rats and mice: sex-, species-, and tissue-dependent differences

Flavin-containing monooxygenase (FMO)-dependent metabolism of methionine and evidence for FMO3 being the major FMO involved in methionine sulfoxidation in rabbit liver and kidney microsomes

N-Biotinyl-S-(1,2-dichlorovinyl)-l-cysteine Sulfoxide as a Potential Model for S-(1,2-Dichlorovinyl)-l-cysteine Sulfoxide: Characterization of Stability and Reactivity with Glutathione and Kidney Proteins in Vitro

Cellular and molecular basis for species, sex and tissue differences in 1,3-butadiene metabolism

Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity

Renal Cellular Transport, Metabolism, and Cytotoxicity of S-(6-Purinyl)glutathione, a Prodrug of 6-Mercaptopurine, and Analogues

Targeting of 6-mercaptopurine to the kidneys. Metabolism and kidney-selectivity of S-(6-purinyl)-L-cysteine analogs in rats

Methimazole protection of rats against chemically induced kidney damage in vivo

Reactivity of cysteine S-conjugate sulfoxides: formation of S-[1-chloro-2-(S-glutathionyl)vinyl]-L-cysteine sulfoxide by the reaction of S-(1,2-dichlorovinyl)-L-cysteine sulfoxide with glutathione

Cysteine S-conjugates may act as kidney-selective prodrugs: formation of 6-mercaptopurine by the renal metabolism of S-(6-purinyl)-L-cysteine

Alpha-ketoacids stimulate rat renal cysteine conjugate beta-lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine

Methimazole as a protectant against cisplatin-induced nephrotoxicity using the dog as a model

S-(1,2-dichlorovinyl)- l-homocysteine-induced cytotoxicity in isolated rat kidney cells

Nephrotoxic amino acid and glutathione S-conjugates: formation and renal activation

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