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Role of reactive metabolites in the circulation in extrahepatic toxicity

Expert opinion on drug metabolism & toxicology, 2012-09, Vol.8 (9), p.1157-1172

2012

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L-methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination

The Journal of pharmacology and experimental therapeutics, 2008-09, Vol.326 (3), p.809-817

2008

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L-methionine-dl-sulfoxide metabolism and toxicity in freshly isolated mouse hepatocytes: gender differences and inhibition with aminooxyacetic acid

Drug metabolism and disposition, 2008-11, Vol.36 (11), p.2252-2260

2008

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Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes

The Journal of pharmacology and experimental therapeutics, 2009-06, Vol.329 (3), p.1148-1155

2009

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S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant

The Journal of pharmacology and experimental therapeutics, 2007-06, Vol.321 (3), p.1095-1101

2007

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Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes

Drug metabolism and disposition, 2008-12, Vol.36 (12), p.2468-2474

2008

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Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design

Expert opinion on drug discovery, 2018-09, Vol.13 (9), p.815-824

2018

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NREL VI rotor blade: numerical investigation and winglet design and optimization using CFD

Wind energy (Chichester, England), 2014-04, Vol.17 (4), p.605-626

2014

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Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties

Expert opinion on drug metabolism & toxicology, 2017-05, Vol.13 (5), p.513-524

2017

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Gender differences in methionine accumulation and metabolism in freshly isolated mouse hepatocytes: Potential roles in toxicity

Toxicology and applied pharmacology, 2009-05, Vol.236 (3), p.358-365

2009

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Roles of necrosis, Apoptosis, and mitochondrial dysfunction in S-(1,2-dichlorovinyl)-L-cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.1163-1172

2003

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In vivo metabolism of L-methionine in mice: evidence for stereoselective formation of methionine-d-sulfoxide and quantitation of other major metabolites

Drug metabolism and disposition, 2006-12, Vol.34 (12), p.2036-2043

2006

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Mercapturic Acid Urinary Metabolites of 3-Butene-1,2-diol as in Vivo Evidence for the Formation of Hydroxymethylvinyl Ketone in Mice and Rats

Chemical research in toxicology, 2004-06, Vol.17 (6), p.819-826

2004

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Hydroxymethylvinyl Ketone: A Reactive Michael Acceptor Formed by the Oxidation of 3-Butene-1,2-diol by cDNA-Expressed Human Cytochrome P450s and Mouse, Rat, and Human Liver Microsomes

Chemical research in toxicology, 2001-12, Vol.14 (12), p.1590-1595

2001

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Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National Cancer Institute's anticancer drug screen

Drug metabolism and disposition, 2004-03, Vol.32 (3), p.321-327

2004

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Mutagenicity of the cysteine S -conjugate sulfoxides of trichloroethylene and tetrachloroethylene in the Ames test

Toxicology (Amsterdam), 2013-04, Vol.306, p.157-161

2013

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Human Liver Microsomes Are Efficient Catalysts of 1,3-Butadiene Oxidation: Evidence for Major Roles by Cytochromes P450 2A6 and 2E1

Archives of biochemistry and biophysics, 1994-06, Vol.311 (2), p.342-349

1994

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In vitro reactions of butadiene monoxide with single- and double-stranded DNA : Characterization and quantitation of several purine and pyrimidine adducts

Carcinogenesis (New York), 1999-02, Vol.20 (2), p.285-292

1999

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Characterization of the Reaction Products of 2‘-Deoxyguanosine and 1,2,3,4-Diepoxybutane after Acid Hydrolysis: Formation of Novel Guanine and Pyrimidine Adducts

Chemical research in toxicology, 2004-04, Vol.17 (4), p.521-528

2004

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Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences

The Journal of pharmacology and experimental therapeutics, 2001-04, Vol.297 (1), p.155

2001

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Alcohol Dehydrogenase- and Rat Liver Cytosol-Dependent Bioactivation of 1‑Chloro-2-hydroxy-3-butene to 1‑Chloro-3-buten-2-one, a Bifunctional Alkylating Agent

Chemical research in toxicology, 2012-11, Vol.25 (11), p.2600-2607

2012

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Identification of a Fused-Ring 2′-Deoxyadenosine Adduct Formed in Human Cells Incubated with 1‑Chloro-3-buten-2-one, a Potential Reactive Metabolite of 1,3-Butadiene

Chemical research in toxicology, 2016-06, Vol.29 (6), p.1041-1050

2016

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Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: evidence for two distinct mechanisms in rats

The Journal of pharmacology and experimental therapeutics, 1999-09, Vol.290 (3), p.950

1999

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Species and sex differences in expression of flavin-containing monooxygenase form 3 in liver and kidney microsomes

Drug metabolism and disposition, 1999-01, Vol.27 (1), p.46

1999

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Role of reactive metabolites in the circulation in extrahepatic toxicity

L-methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination

L-methionine-dl-sulfoxide metabolism and toxicity in freshly isolated mouse hepatocytes: gender differences and inhibition with aminooxyacetic acid

Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes

S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant

Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes

Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design

NREL VI rotor blade: numerical investigation and winglet design and optimization using CFD

Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties

Gender differences in methionine accumulation and metabolism in freshly isolated mouse hepatocytes: Potential roles in toxicity

Roles of necrosis, Apoptosis, and mitochondrial dysfunction in S-(1,2-dichlorovinyl)-L-cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells

In vivo metabolism of L-methionine in mice: evidence for stereoselective formation of methionine-d-sulfoxide and quantitation of other major metabolites

Mercapturic Acid Urinary Metabolites of 3-Butene-1,2-diol as in Vivo Evidence for the Formation of Hydroxymethylvinyl Ketone in Mice and Rats

Hydroxymethylvinyl Ketone: A Reactive Michael Acceptor Formed by the Oxidation of 3-Butene-1,2-diol by cDNA-Expressed Human Cytochrome P450s and Mouse, Rat, and Human Liver Microsomes

Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National Cancer Institute's anticancer drug screen

Mutagenicity of the cysteine S -conjugate sulfoxides of trichloroethylene and tetrachloroethylene in the Ames test

Human Liver Microsomes Are Efficient Catalysts of 1,3-Butadiene Oxidation: Evidence for Major Roles by Cytochromes P450 2A6 and 2E1

In vitro reactions of butadiene monoxide with single- and double-stranded DNA : Characterization and quantitation of several purine and pyrimidine adducts

Characterization of the Reaction Products of 2‘-Deoxyguanosine and 1,2,3,4-Diepoxybutane after Acid Hydrolysis: Formation of Novel Guanine and Pyrimidine Adducts

Compared Performance of the 2023 Duke–International Society for Cardiovascular Infectious Diseases, 2000 Modified Duke, and 2015 European Society of Cardiology Criteria for the Diagnosis of Infective Endocarditis in a French Multicenter Prospective Cohort

Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences

Alcohol Dehydrogenase- and Rat Liver Cytosol-Dependent Bioactivation of 1‑Chloro-2-hydroxy-3-butene to 1‑Chloro-3-buten-2-one, a Bifunctional Alkylating Agent

Identification of a Fused-Ring 2′-Deoxyadenosine Adduct Formed in Human Cells Incubated with 1‑Chloro-3-buten-2-one, a Potential Reactive Metabolite of 1,3-Butadiene

Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: evidence for two distinct mechanisms in rats

Species and sex differences in expression of flavin-containing monooxygenase form 3 in liver and kidney microsomes

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