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Rational design of a new antibiotic class for drug-resistant infections

Nature (London), 2021-09, Vol.597 (7878), p.698-702

2021

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N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay

Bioorganic & medicinal chemistry, 2020-12, Vol.28 (24), p.115826-115826, Article 115826

2020

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Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (19), p.4775-4780

2016

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Whole-Cell-Based Assay To Evaluate Structure Permeation Relationships for Carbapenem Passage through the Pseudomonas aeruginosa Porin OprD

ACS infectious diseases, 2017-04, Vol.3 (4), p.310-319

2017

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Experimental evaluation of an elastic foundation model to predict contact pressures in knee replacements

Journal of biomechanics, 2003-11, Vol.36 (11), p.1659-1668

2003

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An amine protecting group deprotectable under nearly neutral oxidative conditions

Beilstein journal of organic chemistry, 2018-07, Vol.14 (1), p.1750-1757

2018

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Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

The Journal of biological chemistry, 2002-08, Vol.277 (35), p.31499-31505

2002

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Addiction liability of pharmacotherapeutic interventions in obesity

Current pharmaceutical design, 2011-04, Vol.17 (12), p.1188-1192

2011

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2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (11), p.3399-3403

2011

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Synthesis and enzymatic evaluation of a P1 arginine aminocoumarin substrate library for trypsin-like serine proteases

Bioorganic & medicinal chemistry letters, 2000-10, Vol.10 (20), p.2291-2294

2000

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Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering

Bioorganic & medicinal chemistry letters, 2015-12, Vol.25 (24), p.5743-5747

2015

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5‑Carboxytetramethylrhodamine-Ampicillin Fluorescence Anisotropy-Based Assay of Escherichia coli Penicillin-Binding Protein 2 Transpeptidase Inhibition

ACS infectious diseases, 2019-06, Vol.5 (6), p.863-872

2019

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Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency

Journal of medicinal chemistry, 2007-11, Vol.50 (24), p.5912-5925

2007

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Discovery of Efficacious Pseudomonas aeruginosa-Targeted Siderophore-Conjugated Monocarbams by Application of a Semi-mechanistic Pharmacokinetic/Pharmacodynamic Model

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2195-2205

2015

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Ketamine Psychedelic Psychotherapy: Focus on its Pharmacology, Phenomenology, and Clinical Applications

International journal of transpersonal studies, 2014-07, Vol.33 (2), p.84-140

2014

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Discovery of Spirofused Piperazine and Diazepane Amides as Selective Histamine‑3 Antagonists with in Vivo Efficacy in a Mouse Model of Cognition

Journal of medicinal chemistry, 2014-02, Vol.57 (3), p.733-758

2014

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Board and Monitoring Committee Independence

Abacus (Sydney), 2003-06, Vol.39 (2), p.211-232

2003

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SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3

ACS medicinal chemistry letters, 2015-05, Vol.6 (5), p.537-542

2015

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Discovery of ATP-Competitive Inhibitors of tRNAIle Lysidine Synthetase (TilS) by High-Throughput Screening

Journal of biomolecular screening, 2014-09, Vol.19 (8), p.1137-1146

2014

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C3 activation is inhibited by analogs of compstatin but not by serine protease inhibitors or peptidyl α-ketoheterocycles

Immunopharmacology, 2000-07, Vol.48 (2), p.199-212

2000

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[ 125I]YP20: A novel radioligand specific for the extracellular domain of the CRF 1 receptor

European journal of pharmacology, 2010, Vol.649 (1), p.59-63

2010

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[115I]YP20: A novel radioligand specific for the extracellular domain of the CRF1 receptor

European journal of pharmacology, 2010-12, Vol.649 (1-3), p.59-63

2010

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Synthesis and enzymatic evaluation of a P 1 arginine aminocoumarin substrate library for trypsin-like serine proteases

Bioorganic & medicinal chemistry letters, 2000-10, Vol.10 (20), p.2291-2294

2000

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Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa

Chemistry & biology, 2015-04, Vol.22 (4), p.535-547

2015

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Plant The Seed For Voluntary Sales Success

National Underwriter. Life & Health, 2009-09, Vol.113 (18), p.36

Sylvester, Mark

2009

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Rational design of a new antibiotic class for drug-resistant infections

N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay

Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering

Whole-Cell-Based Assay To Evaluate Structure Permeation Relationships for Carbapenem Passage through the Pseudomonas aeruginosa Porin OprD

Experimental evaluation of an elastic foundation model to predict contact pressures in knee replacements

An amine protecting group deprotectable under nearly neutral oxidative conditions

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

Addiction liability of pharmacotherapeutic interventions in obesity

2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity

Synthesis and enzymatic evaluation of a P1 arginine aminocoumarin substrate library for trypsin-like serine proteases

Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering

5‑Carboxytetramethylrhodamine-Ampicillin Fluorescence Anisotropy-Based Assay of Escherichia coli Penicillin-Binding Protein 2 Transpeptidase Inhibition

Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency

Discovery of Efficacious Pseudomonas aeruginosa-Targeted Siderophore-Conjugated Monocarbams by Application of a Semi-mechanistic Pharmacokinetic/Pharmacodynamic Model

Ketamine Psychedelic Psychotherapy: Focus on its Pharmacology, Phenomenology, and Clinical Applications

Discovery of Spirofused Piperazine and Diazepane Amides as Selective Histamine‑3 Antagonists with in Vivo Efficacy in a Mouse Model of Cognition

Board and Monitoring Committee Independence

SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3

Discovery of ATP-Competitive Inhibitors of tRNAIle Lysidine Synthetase (TilS) by High-Throughput Screening

C3 activation is inhibited by analogs of compstatin but not by serine protease inhibitors or peptidyl α-ketoheterocycles

[ 125I]YP20: A novel radioligand specific for the extracellular domain of the CRF 1 receptor

[115I]YP20: A novel radioligand specific for the extracellular domain of the CRF1 receptor

Synthesis and enzymatic evaluation of a P 1 arginine aminocoumarin substrate library for trypsin-like serine proteases

Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa

Plant The Seed For Voluntary Sales Success

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