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Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

Nature (London), 2020-02, Vol.578 (7794), p.306-310

2020

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Discovery of N‑Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo‑1H‑pyrrolo[2,3‑c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain

Journal of medicinal chemistry, 2020-05, Vol.63 (10), p.5585-5623

2020

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Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies

Cancer research (Chicago, Ill.), 2017-06, Vol.77 (11), p.2976-2989

2017

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Highlights of the Structure–Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530)

Journal of medicinal chemistry, 2018-05, Vol.61 (9), p.4052-4066

2018

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Discovery of ABT-267, a Pan-Genotypic Inhibitor of HCV NS5A

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.2047-2057

2014

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Profiling Glucosinolates and Phenolics in Vegetative and Reproductive Tissues of the Multi-Purpose Trees Moringa oleifera L. (Horseradish Tree) and Moringa stenopetala L

Journal of agricultural and food chemistry, 2003-06, Vol.51 (12), p.3546-3553

2003

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In Vivo Imaging of Immune Rejection in Transplanted Pancreatic Islets

Diabetes (New York, N.Y.), 2006-09, Vol.55 (9), p.2419-2428

2006

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Risk Vulnerability and the Tempering Effect of Background Risk

Econometrica, 1996-09, Vol.64 (5), p.1109-1123

1996

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Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.1153-1163

2018

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Discovery of pyrido[2,3-d]pyrimidine-based inhibitors of HCV NS5A

Bioorganic & medicinal chemistry letters, 2013-06, Vol.23 (12), p.3627-3630

2013

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Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (10), p.1804-1810

2018

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Methylpyrrole inhibitors of BET bromodomains

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (10), p.2225-2233

2017

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Nondiscrimination and monotonicity in fair division

Annals of operations research, 2010-04, Vol.176 (1), p.379-387

Pratt, John W.

2010

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Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro

Antimicrobial Agents and Chemotherapy, 2005-10, Vol.49 (10), p.4305-4314

2005

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Nonsteroidal Selective Glucocorticoid Modulators: The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Journal of medicinal chemistry, 2003-03, Vol.46 (6), p.1016-1030

2003

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Orbital Inflammation and Lyme Disease

Ophthalmology (Rochester, Minn.), 2011-09, Vol.118 (9), p.1892.e1-1892.e2

2011

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Mechanistic Study of HCV Polymerase Inhibitors at Individual Steps of the Polymerization Reaction

Biochemistry (Easton), 2006-09, Vol.45 (38), p.11312-11323

2006

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Nonsteroidal Selective Glucocorticoid Modulators: the Effect of C-5 Alkyl Substitution on the Transcriptional Activation/Repression Profile of 2,5-Dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Journal of medicinal chemistry, 2001-12, Vol.44 (25), p.4481-4491

2001

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Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (7), p.1721-1727

2004

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Des-A-ring benzothiadiazines: Inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (8), p.2735-2738

2008

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Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Biological Characterization of Unsymmetrical Dialkyl-Hydroxynaphthalenoyl-benzothiadiazines

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1659-1669

2009

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Citizen scientists filling knowledge gaps of phosphate pollution dynamics in rural areas

Environmental monitoring and assessment, 2024-02, Vol.196 (2), p.220-220, Article 220

2024

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The effect of chronic lorazepam administration in aging mice

Brain research, 2006-11, Vol.1118 (1), p.13-24

2006

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1 – 25 von 1.098

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Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

Discovery of N‑Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo‑1H‑pyrrolo[2,3‑c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain

Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies

Discovery of N‑(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro‑1H‑pyrrolo[2,3‑c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor

Highlights of the Structure–Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530)

Discovery of ABT-267, a Pan-Genotypic Inhibitor of HCV NS5A

Profiling Glucosinolates and Phenolics in Vegetative and Reproductive Tissues of the Multi-Purpose Trees Moringa oleifera L. (Horseradish Tree) and Moringa stenopetala L

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors

In Vivo Imaging of Immune Rejection in Transplanted Pancreatic Islets

Risk Vulnerability and the Tempering Effect of Background Risk

Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability

Discovery of pyrido[2,3-d]pyrimidine-based inhibitors of HCV NS5A

Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors

Methylpyrrole inhibitors of BET bromodomains

Nondiscrimination and monotonicity in fair division

Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro

Nonsteroidal Selective Glucocorticoid Modulators: The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Orbital Inflammation and Lyme Disease

Mechanistic Study of HCV Polymerase Inhibitors at Individual Steps of the Polymerization Reaction

Nonsteroidal Selective Glucocorticoid Modulators: the Effect of C-5 Alkyl Substitution on the Transcriptional Activation/Repression Profile of 2,5-Dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators

Des-A-ring benzothiadiazines: Inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase

Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Biological Characterization of Unsymmetrical Dialkyl-Hydroxynaphthalenoyl-benzothiadiazines

Citizen scientists filling knowledge gaps of phosphate pollution dynamics in rural areas

The effect of chronic lorazepam administration in aging mice

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