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Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro

Antimicrobial Agents and Chemotherapy, 2005-10, Vol.49 (10), p.4305-4314

2005

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A new class of potent non-imidazole H3 antagonists: 2-aminoethylbenzofurans

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (3), p.689-693

2004

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Nonsteroidal Selective Glucocorticoid Modulators: The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Journal of medicinal chemistry, 2003-03, Vol.46 (6), p.1016-1030

2003

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Nonsteroidal Selective Glucocorticoid Modulators: the Effect of C-5 Alkyl Substitution on the Transcriptional Activation/Repression Profile of 2,5-Dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Journal of medicinal chemistry, 2001-12, Vol.44 (25), p.4481-4491

2001

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Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (7), p.1721-1727

2004

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Des-A-ring benzothiadiazines: Inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (8), p.2735-2738

2008

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Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Biological Characterization of Unsymmetrical Dialkyl-Hydroxynaphthalenoyl-benzothiadiazines

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1659-1669

2009

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Inhibitors of HCV NS5B polymerase: synthesis and structure–activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines

Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (6), p.1577-1582

2005

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Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3833-3838

2006

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Identification of halosalicylamide derivatives as a novel class of allosteric inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2008-06, Vol.18 (11), p.3173-3177

2008

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Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (13), p.3367-3370

2006

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The effect of chronic lorazepam administration in aging mice

Brain research, 2006-11, Vol.1118 (1), p.13-24

2006

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Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2079-2082

2004

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In vitro Optimization of Structure Activity Relationships of Analogues of A‐331440 Combining Radioligand Receptor Binding Assays and Micronucleus Assays of Potential Antiobesity Histamine H3 Receptor Antagonists

Basic & clinical pharmacology & toxicology, 2004-09, Vol.95 (3), p.144-152

2004

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Pyridopyrimidine analogues as novel adenosine kinase inhibitors

Bioorganic & medicinal chemistry letters, 2001-08, Vol.11 (16), p.2071-2074

2001

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Structure−Activity Studies for a Novel Series of Bicyclic Substituted Hexahydrobenz[e]isoindole α1A Adrenoceptor Antagonists as Potential Agents for the Symptomatic Treatment of Benign Prostatic Hyperplasia

Journal of medicinal chemistry, 2001-06, Vol.44 (12), p.1971-1985

2001

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Pharmacodynamic and receptor binding changes during chronic lorazepam administration

Pharmacology, biochemistry and behavior, 2001-05, Vol.69 (1), p.1-8

2001

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D-Amino Acid Homopiperazine Amides: Discovery of A-320436, a Potent and Selective Non-Imidazole Histamine H3-Receptor Antagonist

Archiv der Pharmazie (Weinheim), 2004-04, Vol.337 (4), p.219-229

2004

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Lorazepam Attenuates the Behavioral Effects of Dizocilpine

Pharmacology, biochemistry and behavior, 1999-01, Vol.62 (1), p.103-110

1999

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Adenosine kinase inhibitors: Polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity: Recent advances in the design of kinase inhibitors as novel therapeutic agents

Bioorganic & medicinal chemistry letters, 2003, Vol.13 (18), p.3041-3044

2003

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5-Membered ring heterocyclic carboxylic acids as angiotensin II antagonists

Bioorganic & medicinal chemistry letters, 1994-01, Vol.4 (1), p.169-172

1994

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Adrenal suppression by oral high-dose medroxyprogesterone acetate in breast cancer patients

Cancer chemotherapy and pharmacology, 1984-01, Vol.12 (2), p.83-86

1984

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Vernakalant Hydrochloride for Rapid Conversion of Atrial Fibrillation : A Phase 3, Randomized, Placebo-Controlled Trial

Circulation (New York, N.Y.), 2008-03, Vol.117 (12), p.1518-1525

2008

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Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction

The Lancet (British edition), 1996-07, Vol.348 (9019), p.7-12

1996

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Approaches to the simultaneous inactivation of metallo-and serine-β-lactamases

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (6), p.1618-1622

2009

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Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro

A new class of potent non-imidazole H3 antagonists: 2-aminoethylbenzofurans

Nonsteroidal Selective Glucocorticoid Modulators: The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Nonsteroidal Selective Glucocorticoid Modulators: the Effect of C-5 Alkyl Substitution on the Transcriptional Activation/Repression Profile of 2,5-Dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators

Des-A-ring benzothiadiazines: Inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase

Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Biological Characterization of Unsymmetrical Dialkyl-Hydroxynaphthalenoyl-benzothiadiazines

Inhibitors of HCV NS5B polymerase: synthesis and structure–activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines

Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring

Identification of halosalicylamide derivatives as a novel class of allosteric inhibitors of HCV NS5B polymerase

Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides

The effect of chronic lorazepam administration in aging mice

Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists

In vitro Optimization of Structure Activity Relationships of Analogues of A‐331440 Combining Radioligand Receptor Binding Assays and Micronucleus Assays of Potential Antiobesity Histamine H3 Receptor Antagonists

Pyridopyrimidine analogues as novel adenosine kinase inhibitors

Structure−Activity Studies for a Novel Series of Bicyclic Substituted Hexahydrobenz[e]isoindole α1A Adrenoceptor Antagonists as Potential Agents for the Symptomatic Treatment of Benign Prostatic Hyperplasia

Pharmacodynamic and receptor binding changes during chronic lorazepam administration

D-Amino Acid Homopiperazine Amides: Discovery of A-320436, a Potent and Selective Non-Imidazole Histamine H3-Receptor Antagonist

Lorazepam Attenuates the Behavioral Effects of Dizocilpine

Adenosine kinase inhibitors: Polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity: Recent advances in the design of kinase inhibitors as novel therapeutic agents

5-Membered ring heterocyclic carboxylic acids as angiotensin II antagonists

Adrenal suppression by oral high-dose medroxyprogesterone acetate in breast cancer patients

Vernakalant Hydrochloride for Rapid Conversion of Atrial Fibrillation : A Phase 3, Randomized, Placebo-Controlled Trial

Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction

Approaches to the simultaneous inactivation of metallo-and serine-β-lactamases

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