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Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level

Nature communications, 2018-08, Vol.9 (1), p.3243-12, Article 3243

2018

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Biocatalytic synthesis of chiral five-membered carbasugars intermediates utilizing CV2025 ω-transaminase from Chromobacterium violaceum

Journal of bioscience and bioengineering, 2023-05, Vol.135 (5), p.369-374

2023

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Design and synthesis of N–acetylglucosamine derived 5a-carbasugar analogues as glycosidase inhibitors

Tetrahedron, 2018-04, Vol.74 (15), p.1957-1964

2018

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Application of a tandem seleno-michael/aldol reaction in the total syntheses of (+)-Pericosine B, (+)-Pericosine C, (+)-COTC and 7-chloro-analogue of (+)-Gabosine C

Tetrahedron, 2020-08, Vol.76 (34), p.131397, Article 131397

2020

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Synthesis of 5a,5a′-dicarba-d-glucobioses from conformationally restricted carbaglucosyl triflates using SN2-type inversion with carbaglucosyl nucleophiles

Bioorganic & medicinal chemistry, 2019-06, Vol.27 (12), p.2345-2367

2019

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Highly functionalized cyclic and bicyclic β−amino acids from sugar β−nitroesters

Tetrahedron, 2020-01, Vol.76 (3), p.130837, Article 130837

2020

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Carbasugar probes to explore the enzyme binding pocket at the anomeric position: application to the design of Golgi mannosidase II inhibitors

Current medicinal chemistry, 2013-10, Vol.20 (30), p.3797-3801

2013

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Carba-d,l-allal- and -d,l-galactal-derived vinyl N-nosyl aziridines as useful tools for the synthesis of 4-deoxy-4-(N-nosylamino)-2,3-unsaturated-5a-carbasugars

Tetrahedron, 2017-11, Vol.73 (48), p.6677-6695

2017

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Antileishmanial Carbasugars from Geosmithia langdonii

Journal of natural products (Washington, D.C.), 2018-10, Vol.81 (10), p.2222-2227

2018

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Synthesis of Highly Oxygenated Bicyclic Carbasugars. Remarkable Difference in the Reactivity of the d- gluco and d -xylo- Derived Trienes

Molecules (Basel, Switzerland), 2020-07, Vol.25 (15), p.3357

2020

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Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus

ACS chemical biology, 2011-07, Vol.6 (7), p.675-678

2011

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Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C -5a-Substituted Derivatives of 4- epi -Isofagomine

Molecules (Basel, Switzerland), 2020-09, Vol.25 (17), p.4025

2020

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Synergy of R-(-)carvone and cyclohexenone-based carbasugar precursors with antibiotics to enhance antibiotic potency and inhibit biofilm formation

Scientific reports, 2022-10, Vol.12 (1), p.18019-18019, Article 18019

2022

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Comparative Metabolomic Analysis of an Alternative Biosynthetic Pathway to Pseudosugars in Actinosynnema mirum DSM 43827

Chembiochem : a European journal of chemical biology, 2013-09, Vol.14 (13), p.1548-1551

2013

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Design and synthesis of biologically active carbaglycosylamines: From glycosidase inhibitors to pharmacological chaperones

Proceedings of the Japan Academy, Series B, 2022/07/29, Vol.98(7), pp.336-360

2022

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Review of Total Synthesis of Valienamine

Yŏujī huàxué, 2016-12, Vol.36 (12), p.2771

2016

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The Structure and Stereochemistry of Gabosine K: Syntheses of 7-O-Acetylstreptol and 7-O-Acetyl-1-epi-streptol

Synlett, 2010, Vol.2010 (1), p.142-144

2010

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Glycosidase inhibitors: a patent review (2008 - 2013)

Expert opinion on therapeutic patents, 2014-08, Vol.24 (8), p.857-874

2014

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A quantitative analytical method for valienone and its application in the evaluation of valienone production by a breakthrough microbial process

Chinese journal of natural medicines, 2017-10, Vol.15 (10), p.794-800

2017

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From Quercitols to Biologically Active Valienamine and Conduramine Derivatives: Development of Pharmacological Chaperones

Trends in Glycoscience and Glycotechnology, 2016/01/25, Vol.28(159), pp.J13-J22

2016

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Olefin Metathesis - Application in the Synthesis of Natural Products and Related Organic Compounds

Proceedings of the Indian National Science Academy, Part A: Physical sciences, 2014-03, Vol.80 (1), p.37

2014

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Development of Phyllanthusmin Derivatives as Anticancer Agents: Pharmacological Optimization and Mechanistic Insight

Huntsman, Andrew C

2019

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From Quercitols to Biologically Active Valienamine and Conduramine Derivatives: Development of Pharmacological Chaperones

Trends in Glycoscience and Glycotechnology, 2016/01/25, Vol.28(159), pp.E13-E22

2016

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クエルシトールから生理活性バリエナミン、コンデュラミン誘導体へ：薬理学的シャペロン治療薬の開発

Trends in Glycoscience and Glycotechnology, 2016/01/25, Vol.28(159), pp.J13-J22

2016

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Recent Advances in the Synthesis of the Carbocyclic Nucleosides as Potential Antiviral Agents

Antiviral Chemistry and Chemotherapy, 2004-10, Vol.15 (5), p.235-250

2004

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Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level

Biocatalytic synthesis of chiral five-membered carbasugars intermediates utilizing CV2025 ω-transaminase from Chromobacterium violaceum

Design and synthesis of N–acetylglucosamine derived 5a-carbasugar analogues as glycosidase inhibitors

Application of a tandem seleno-michael/aldol reaction in the total syntheses of (+)-Pericosine B, (+)-Pericosine C, (+)-COTC and 7-chloro-analogue of (+)-Gabosine C

Synthesis of 5a,5a′-dicarba-d-glucobioses from conformationally restricted carbaglucosyl triflates using SN2-type inversion with carbaglucosyl nucleophiles

Highly functionalized cyclic and bicyclic β−amino acids from sugar β−nitroesters

Carbasugar probes to explore the enzyme binding pocket at the anomeric position: application to the design of Golgi mannosidase II inhibitors

Carba-d,l-allal- and -d,l-galactal-derived vinyl N-nosyl aziridines as useful tools for the synthesis of 4-deoxy-4-(N-nosylamino)-2,3-unsaturated-5a-carbasugars

Antileishmanial Carbasugars from Geosmithia langdonii

Synthesis of Highly Oxygenated Bicyclic Carbasugars. Remarkable Difference in the Reactivity of the d- gluco and d -xylo- Derived Trienes

Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus

Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C -5a-Substituted Derivatives of 4- epi -Isofagomine

Synergy of R-(-)carvone and cyclohexenone-based carbasugar precursors with antibiotics to enhance antibiotic potency and inhibit biofilm formation

Comparative Metabolomic Analysis of an Alternative Biosynthetic Pathway to Pseudosugars in Actinosynnema mirum DSM 43827

Design and synthesis of biologically active carbaglycosylamines: From glycosidase inhibitors to pharmacological chaperones

Review of Total Synthesis of Valienamine

The Structure and Stereochemistry of Gabosine K: Syntheses of 7-O-Acetylstreptol and 7-O-Acetyl-1-epi-streptol

Glycosidase inhibitors: a patent review (2008 - 2013)

A quantitative analytical method for valienone and its application in the evaluation of valienone production by a breakthrough microbial process

From Quercitols to Biologically Active Valienamine and Conduramine Derivatives: Development of Pharmacological Chaperones

Olefin Metathesis - Application in the Synthesis of Natural Products and Related Organic Compounds

Development of Phyllanthusmin Derivatives as Anticancer Agents: Pharmacological Optimization and Mechanistic Insight

From Quercitols to Biologically Active Valienamine and Conduramine Derivatives: Development of Pharmacological Chaperones

クエルシトールから生理活性バリエナミン、コンデュラミン誘導体へ：薬理学的シャペロン治療薬の開発

Recent Advances in the Synthesis of the Carbocyclic Nucleosides as Potential Antiviral Agents

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