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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

PloS one, 2018-11, Vol.13 (11), p.e0206279-e0206279

2018

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In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates

Drug metabolism and disposition, 2003-08, Vol.31 (8), p.1005

2003

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Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4

Drug metabolism and disposition, 2005-02, Vol.33 (2), p.243

2005

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A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

Journal of medicinal chemistry, 2014-02, Vol.57 (4), p.1616-1620

2014

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Epoxidation of Olefins by Cytochrome P450: Evidence from Site-Specific Mutagenesis for Hydroperoxo-Iron as an Electrophilic Oxidant

Proceedings of the National Academy of Sciences - PNAS, 1998-03, Vol.95 (7), p.3555-3560

1998

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Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

Drug metabolism and disposition, 2012-03, Vol.40 (3), p.625

2012

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Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug Resistant Community-Acquired Respiratory Tract Infections

Journal of medicinal chemistry, 2009-12, Vol.52 (23), p.7446-7457

2009

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On the Mechanism of Action of Cytochrome P450: Evaluation of Hydrogen Abstraction in Oxygen-Dependent Alcohol Oxidation

Biochemistry (Easton), 1994-05, Vol.33 (21), p.6442-6449

1994

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Discrete Species of Activated Oxygen Yield Different Cytochrome P450 Heme Adducts from Aldehydes

Biochemistry (Easton), 1999-08, Vol.38 (32), p.10511-10518

1999

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Peroxo-Iron and Oxenoid-Iron Species as Alternative Oxygenating Agents in Cytochrome P450-Catalyzed Reactions: Switching by Threonine-302 to Alanine Mutagenesis of Cytochrome P450 2B4

Proceedings of the National Academy of Sciences - PNAS, 1996-05, Vol.93 (10), p.4644-4648

1996

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The use of 18O-exchange and base-catalyzed N-dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

Rapid communications in mass spectrometry, 2010-07, Vol.24 (14), p.2151-2161

2010

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Old yellow enzyme: Aromatization of cyclic enones and the mechanism of a novel dismutation reaction

Biochemistry (Easton), 1995-04, Vol.34 (13), p.4246-4256

1995

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Aromatization of a Bicyclic Steroid Analog, 3-Oxodecalin-4-ene-10-carboxaldehyde, by Liver Microsomal Cytochrome P450 2B4

Biochemistry (Easton), 1994-11, Vol.33 (46), p.13651-13661

1994

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Two Distinct Electrophilic Oxidants Effect Hydroxyl- ation in Cytochrome P-450-Catalyzed Reactions

Journal of the American Chemical Society, 1998-09, Vol.120 (37), p.9718-9719

1998

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Mechanism-Based Inactivation of Cytochrome P450 2B4 by Aldehydes: Relationship to Aldehyde Deformylation via a Peroxyhemiacetal Intermediate

Biochemistry (Easton), 1997-04, Vol.36 (16), p.4895-4902

1997

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A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry: CID product ion tracking of protein-small molecule complexes

Rapid communications in mass spectrometry, 2015-11, Vol.29 (22), p.2175-2183

2015

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1,2,3-Thiadiazole: A Novel Heterocyclic Heme Ligand for the Design of Cytochrome P450 Inhibitors

Biochemistry (Easton), 1997-06, Vol.36 (23), p.7209-7216

1997

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Inactivation of Ethanol-Inducible Cytochrome P450 and Other Microsomal P450 Isozymes by Trans-4-Hydroxy-2-Nonenal, a Major Product of Membrane Lipid Peroxidation

Proceedings of the National Academy of Sciences - PNAS, 1995-04, Vol.92 (9), p.3764-3768

1995

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Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis: implications for treatment of tuberculosis

Biochemical pharmacology, 2001-06, Vol.61 (12), p.1463-1470

2001

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Significance of Glycine 478 in the Metabolism of N-Benzyl-1-aminobenzotriazole to Reactive Intermediates by Cytochrome P450 2B1

Biochemistry (Easton), 1997-09, Vol.36 (39), p.11707-11716

1997

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The use of 18 O‐exchange and base‐catalyzed N ‐dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

Rapid communications in mass spectrometry, 2010-07, Vol.24 (14), p.2151-2161

2010

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Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4

Chemico-biological interactions, 2005-06, Vol.155 (1), p.10-20

2005

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MT FdR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51

Biochimica et biophysica acta, 2005-04, Vol.1707 (2), p.157-169

2005

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Cytochrome P450: progress and predictions

The FASEB journal, 1992-01, Vol.6 (2), p.669-673

1992

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Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide [Erratum to document cited in CA115(5):48632c]

Journal of the American Chemical Society, 1991-11, Vol.113 (23), p.9009-9009

1991

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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates

Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4

A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

Epoxidation of Olefins by Cytochrome P450: Evidence from Site-Specific Mutagenesis for Hydroperoxo-Iron as an Electrophilic Oxidant

Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug Resistant Community-Acquired Respiratory Tract Infections

On the Mechanism of Action of Cytochrome P450: Evaluation of Hydrogen Abstraction in Oxygen-Dependent Alcohol Oxidation

Discrete Species of Activated Oxygen Yield Different Cytochrome P450 Heme Adducts from Aldehydes

Peroxo-Iron and Oxenoid-Iron Species as Alternative Oxygenating Agents in Cytochrome P450-Catalyzed Reactions: Switching by Threonine-302 to Alanine Mutagenesis of Cytochrome P450 2B4

The use of 18O-exchange and base-catalyzed N-dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

Old yellow enzyme: Aromatization of cyclic enones and the mechanism of a novel dismutation reaction

Aromatization of a Bicyclic Steroid Analog, 3-Oxodecalin-4-ene-10-carboxaldehyde, by Liver Microsomal Cytochrome P450 2B4

Two Distinct Electrophilic Oxidants Effect Hydroxyl- ation in Cytochrome P-450-Catalyzed Reactions

Mechanism-Based Inactivation of Cytochrome P450 2B4 by Aldehydes: Relationship to Aldehyde Deformylation via a Peroxyhemiacetal Intermediate

A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry: CID product ion tracking of protein-small molecule complexes

1,2,3-Thiadiazole: A Novel Heterocyclic Heme Ligand for the Design of Cytochrome P450 Inhibitors

Inactivation of Ethanol-Inducible Cytochrome P450 and Other Microsomal P450 Isozymes by Trans-4-Hydroxy-2-Nonenal, a Major Product of Membrane Lipid Peroxidation

Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis: implications for treatment of tuberculosis

Significance of Glycine 478 in the Metabolism of N-Benzyl-1-aminobenzotriazole to Reactive Intermediates by Cytochrome P450 2B1

The use of 18 O‐exchange and base‐catalyzed N ‐dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4

MT FdR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51

Cytochrome P450: progress and predictions

Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide [Erratum to document cited in CA115(5):48632c]

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