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Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria

Journal of medicinal chemistry, 2020-07, Vol.63 (14), p.7773-7816

2020

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Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria

Journal of medicinal chemistry, 2021-05, Vol.64 (9), p.6329-6357

2021

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Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3309-3324

2018

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Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3325-3349

2018

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Optimization of CoaD Inhibitors against Gram-Negative Organisms through Targeted Metabolomics

ACS infectious diseases, 2018-03, Vol.4 (3), p.391-402

2018

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Rhizochalins C and D from the Sponge Rhizochalina incrustata. A Rare threo-Sphingolipid and a Facile Method for Determination of the Carbonyl Position in α,ω-Bifunctionalized Ketosphingolipids

Journal of natural products (Washington, D.C.), 2007-12, Vol.70 (12), p.1991-1998

2007

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Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activityElectronic supplementary information (ESI) available: Full experimental details and copies of 1H and 13C NMR spectra are provided. CCDC 1475225-1475228. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc04146a

2017-01

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Long-Chain 2 H -Azirines with Heterogeneous Terminal Halogenation from the Marine Sponge Dysidea fragilis

Journal of organic chemistry, 2008-04, Vol.73 (7), p.2592-2597

2008

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Synthesis and chain-dependent antifungal activity of long-chain 2 H-azirine-carboxylate esters related to dysidazirine

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (6), p.2029-2032

2010

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Synthesis and Anti-fungal Activity of (−)-(Z)-Dysidazirine

Organic letters, 2008-10, Vol.10 (22), p.5269-5271

2008

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A Tetrachloro Polyketide Hexahydro-1 H -isoindolone, Muironolide A, from the Marine Sponge Phorbas sp. Natural Products at the Nanomole Scale

Journal of the American Chemical Society, 2009-06, Vol.131 (22), p.7552-7553

2009

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Addition of Cl 2 C: to (−)- O -Menthyl Acrylate under Sonication−Phase-Transfer Catalysis. Efficient Synthesis of (+)- and (−)-(2-Chlorocyclopropyl)methanol

Journal of organic chemistry, 2005-05, Vol.70 (10), p.4162-4165

2005

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ChemInform Abstract: Long-Chain 2H-Azirines with Heterogeneous Terminal Halogenation from the Marine Sponge Dysidea fragilis

ChemInform, 2008-08, Vol.39 (34), p.no-no

2008

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ChemInform Abstract: A Tetrachloro Polyketide Hexahydro-1H-isoindolone, Muironolide A from the Marine Sponge Phorbas sp. Natural Products at the Nanomole Scale

ChemInform, 2009-11, Vol.40 (44), p.no-no

2009

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ChemInform Abstract: Phorbasides A-E, Cytotoxic Chlorocyclopropane Macrolide Glycosides from the Marine Sponge Phorbas sp. CD Determination of C-Methyl Sugar Configurations

ChemInform, 2008-09, Vol.39 (39), p.no-no

2008

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Paclitaxel Affects Cytosolic Calcium Signals by Opening the Mitochondrial Permeability Transition Pore

The Journal of biological chemistry, 2002-02, Vol.277 (8), p.6504-6510

2002

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Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria

Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria

Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria

Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity

Optimization of CoaD Inhibitors against Gram-Negative Organisms through Targeted Metabolomics

Rhizochalins C and D from the Sponge Rhizochalina incrustata. A Rare threo-Sphingolipid and a Facile Method for Determination of the Carbonyl Position in α,ω-Bifunctionalized Ketosphingolipids

Long-Chain 2 H -Azirines with Heterogeneous Terminal Halogenation from the Marine Sponge Dysidea fragilis

Synthesis and chain-dependent antifungal activity of long-chain 2 H-azirine-carboxylate esters related to dysidazirine

Synthesis and Anti-fungal Activity of (−)-(Z)-Dysidazirine

A Tetrachloro Polyketide Hexahydro-1 H -isoindolone, Muironolide A, from the Marine Sponge Phorbas sp. Natural Products at the Nanomole Scale

Addition of Cl 2 C: to (−)- O -Menthyl Acrylate under Sonication−Phase-Transfer Catalysis. Efficient Synthesis of (+)- and (−)-(2-Chlorocyclopropyl)methanol

ChemInform Abstract: Long-Chain 2H-Azirines with Heterogeneous Terminal Halogenation from the Marine Sponge Dysidea fragilis

ChemInform Abstract: A Tetrachloro Polyketide Hexahydro-1H-isoindolone, Muironolide A from the Marine Sponge Phorbas sp. Natural Products at the Nanomole Scale

ChemInform Abstract: Phorbasides A-E, Cytotoxic Chlorocyclopropane Macrolide Glycosides from the Marine Sponge Phorbas sp. CD Determination of C-Methyl Sugar Configurations

Paclitaxel Affects Cytosolic Calcium Signals by Opening the Mitochondrial Permeability Transition Pore

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