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Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure−Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid (BMS-688521)

Journal of medicinal chemistry, 2010-05, Vol.53 (9), p.3814-3830

2010

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Novel Synthesis of the Hexahydroimidazo[1,5b]isoquinoline Scaffold: Application to the Synthesis of Glucocorticoid Receptor Modulators

Journal of medicinal chemistry, 2010-02, Vol.53 (3), p.1270-1280

2010

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Identification and Preclinical Pharmacology of ((1R,3S)‑1-Amino-3-((S)‑6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials

Journal of medicinal chemistry, 2019-03, Vol.62 (5), p.2265-2285

2019

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Perspectives on Nuclear Magnetic Resonance Spectroscopy in Drug Discovery Research

Journal of medicinal chemistry, 2024-02, Vol.67 (3), p.1701-1733

2024

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Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling

Nature (London), 2023-11, Vol.623 (7988), p.745-751

2023

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RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation

The Journal of immunology (1950), 2019-01, Vol.202 (1), p.79-92

2019

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Acridone-Based Inhibitors of Inosine 5‘-Monophosphate Dehydrogenase: Discovery and SAR Leading to the Identification of N-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)

Journal of medicinal chemistry, 2007-07, Vol.50 (15), p.3730-3742

2007

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Rationally Designed, Conformationally Constrained Inverse Agonists of RORγtIdentification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy

Journal of medicinal chemistry, 2019-11, Vol.62 (21), p.9931-9946

2019

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Special issue of Medicinal Chemistry Research in honor of Dr. Nicholas A. Meanwell

Medicinal chemistry research, 2023-07, Vol.32 (7), p.1205-1207

2023

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Tricyclic-Carbocyclic RORγt Inverse AgonistsDiscovery of BMS-986313

Journal of medicinal chemistry, 2021-03, Vol.64 (5), p.2714-2724

2021

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Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.15050-15071

2020

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Correction: RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation

The Journal of immunology (1950), 2021-06, Vol.206 (11), p.2764-2765

2021

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Pharmacological inhibition of RORC2 enhances human Th17‐Treg stability and function

European journal of immunology, 2020-09, Vol.50 (9), p.1400-1411

2020

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Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists

ACS medicinal chemistry letters, 2019-03, Vol.10 (3), p.367-373

2019

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Bicyclic Ligand-Biased Agonists of S1P1: Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles

Journal of medicinal chemistry, 2021-02, Vol.64 (3), p.1454-1480

2021

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Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist

ACS medicinal chemistry letters, 2020-06, Vol.11 (6), p.1221-1227

2020

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Bicyclic Ligand-Biased Agonists of S1P 1 : Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles

Journal of medicinal chemistry, 2021-02, Vol.64 (3), p.1454-1480

2021

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Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach

ACS medicinal chemistry letters, 2020-12, Vol.11 (12), p.2510-2518

2020

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Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P1) Modulators: Optimization of the PK, PD, and Safety Profiles

ACS medicinal chemistry letters, 2020-09, Vol.11 (9), p.1766-1772

2020

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Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure−Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid (BMS-688521)

Novel Synthesis of the Hexahydroimidazo[1,5b]isoquinoline Scaffold: Application to the Synthesis of Glucocorticoid Receptor Modulators

Identification and Preclinical Pharmacology of ((1R,3S)‑1-Amino-3-((S)‑6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials

Perspectives on Nuclear Magnetic Resonance Spectroscopy in Drug Discovery Research

Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design

Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling

RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation

Acridone-Based Inhibitors of Inosine 5‘-Monophosphate Dehydrogenase: Discovery and SAR Leading to the Identification of N-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)

Rationally Designed, Conformationally Constrained Inverse Agonists of RORγtIdentification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy

Special issue of Medicinal Chemistry Research in honor of Dr. Nicholas A. Meanwell

Tricyclic-Carbocyclic RORγt Inverse AgonistsDiscovery of BMS-986313

Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches

Identification of potent tricyclic prodrug S1P1 receptor modulators

Correction: RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation

Pharmacological inhibition of RORC2 enhances human Th17‐Treg stability and function

Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists

Bicyclic Ligand-Biased Agonists of S1P1: Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist

Bicyclic Ligand-Biased Agonists of S1P 1 : Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles

Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach

Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P1) Modulators: Optimization of the PK, PD, and Safety Profiles

Discovery of N-[2-[2-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a Novel and Potent Inhibitor of Inosine Monophosphate Dehydrogenase with Excellent in Vivo Activity

Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)‑1-Amino-3-((R)‑6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator

Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor

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