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Late-stage meta-C–H alkylation of pharmaceuticals to modulate biological properties and expedite molecular optimisation in a single step

Nature communications, 2024-04, Vol.15 (1), p.3349-3349, Article 3349

2024

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Late-stage synthesis of heterobifunctional molecules for PROTAC applications via ruthenium-catalysed C‒H amidation

Nature communications, 2023-12, Vol.14 (1), p.8222-8222, Article 8222

2023

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Oxalate Oxidase for In Situ H 2 O 2 -Generation in Unspecific Peroxygenase-Catalysed Drug Oxyfunctionalisations

Angewandte Chemie International Edition, 2022-09, Vol.61 (39), p.e202207831

2022

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Ir III -Catalyzed Selective ortho-Monoiodination of Benzoic Acids with Unbiased C-H Bonds

Chemistry : a European journal, 2020-08, Vol.26 (45), p.10185-10190

2020

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Effects of mineral oil administration on the pharmacokinetics, metabolism and pharmacodynamics of atorvastatin and pravastatin in mice and dogs

European journal of pharmaceutical sciences, 2021-06, Vol.161, p.105776, Article 105776

2021

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Iridium-catalyzed C-H methylation and d 3 -methylation of benzoic acids with application to late-stage functionalizations

iScience, 2021-05, Vol.24 (5), p.102467

2021

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GPR103 Antagonists Demonstrating Anorexigenic Activity in Vivo: Design and Development of Pyrrolo[2,3‑c]pyridines That Mimic the C‑Terminal Arg-Phe Motif of QRFP26

Journal of medicinal chemistry, 2014-07, Vol.57 (14), p.5935-5948

2014

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Efficient DBU accelerated synthesis of 18 F-labelled trifluoroacetamides

Chemical communications (Cambridge, England), 2016, Vol.52 (97), p.13963-13966

2016

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Design and Optimization of Pyrazinecarboxamide-Based Inhibitors of Diacylglycerol Acyltransferase 1 (DGAT1) Leading to a Clinical Candidate Dimethylpyrazinecarboxamide Phenylcyclohexylacetic Acid (AZD7687)

Journal of medicinal chemistry, 2012-12, Vol.55 (23), p.10610-10629

2012

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Correction to GPR103 Antagonists Demonstrating Anorexigenic Activity in Vivo: Design and Development of Pyrrolo[2,3‑c]pyridines That Mimic the C‑Terminal Arg-Phe Motif of QRFP26

Journal of medicinal chemistry, 2015-05, Vol.58 (9), p.4086-4086

2015

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Uncatalyzed Diboron Activation by a Strained Hydrocarbon: Experimental and Theoretical Study of 1.1.1Propellane Diborylation

Chemistry : a European journal, 2024-09, Vol.30 (52), p.e202402152

2024

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C–H activation

Nature Reviews Methods Primers, 2021-12, Vol.1 (1), Article 43

2021

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Cover Feature: IrIII‐Catalyzed Selective ortho‐Monoiodination of Benzoic Acids with Unbiased C−H Bonds (Chem. Eur. J. 45/2020)

Chemistry : a European journal, 2020-08, Vol.26 (45), p.10155-10155

2020

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Cover Feature: Ir III ‐Catalyzed Selective ortho ‐Monoiodination of Benzoic Acids with Unbiased C−H Bonds (Chem. Eur. J. 45/2020)

Chemistry : a European journal, 2020-08, Vol.26 (45), p.10155-10155

2020

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Oxalate Oxidase for In Situ H2 O2 -Generation in Unspecific Peroxygenase-Catalysed Drug Oxyfunctionalisations

Angewandte Chemie International Edition, 2022-09, Vol.61 (39), p.e202207831

2022

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Cover Feature: Electrochemical Proton Reduction over Nickel Foam for Z‐Stereoselective Semihydrogenation/deuteration of Functionalized Alkynes (ChemSusChem 1/2022)

ChemSusChem, 2022-01, Vol.15 (1), p.n/a

2022

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Back Cover: General Cyclopropane Assembly by Enantioselective Transfer of a Redox‐Active Carbene to Aliphatic Olefins (Angew. Chem. Int. Ed. 18/2019)

Angewandte Chemie International Edition, 2019-04, Vol.58 (18), p.6106-6106

2019

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Merging Directed C-H Activations with High-throughput Experimentation: Development of Predictable Iridium-catalyzed C-H Aminations Applicable to Late-stage Functionalizations

JACS Au, 2022, Vol.2 (4), p.906

2022

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Efficient DBU accelerated synthesis of 18F-labelled trifluoroacetamidesElectronic supplementary information (ESI) available: Experimental procedures, characterization, radiochemistry and spectral data. See DOI: 10.1039/c6cc08535k

2016-11

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Oxalate Oxidase for In Situ H 2 O 2 ‐Generation in Unspecific Peroxygenase‐Catalysed Drug Oxyfunctionalisations

Angewandte Chemie, 2022-09, Vol.134 (39)

2022

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Nanopalladium-catalyzed conjugate reduction of Michael acceptors - application in flowElectronic supplementary information (ESI) available. See DOI: 10.1039/c5gc02920a

2016-05

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Efficient DBU accelerated synthesis of F-18-labelled trifluoroacetamides

Chemical communications (Cambridge, England), 2016, Vol.52 (97), p.13963

2016

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Selective Heterogeneous C-H Activation/Halogenation Reactions Catalyzed by PdOF Nanocomposites

Chemistry : a European journal, 2016-03, Vol.22 (11), p.3729-3737

2016

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Rücktitelbild: General Cyclopropane Assembly by Enantioselective Transfer of a Redox‐Active Carbene to Aliphatic Olefins (Angew. Chem. 18/2019)

Angewandte Chemie, 2019-04, Vol.131 (18), p.6166-6166

2019

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ChemInform Abstract: Scalable Synthesis of Piperazines Enabled by Visible‐Light Irradiation and Aluminum Organometallics

ChemInform, 2016-03, Vol.47 (13), p.no-no

2016

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Late-stage meta-C–H alkylation of pharmaceuticals to modulate biological properties and expedite molecular optimisation in a single step

Late-stage synthesis of heterobifunctional molecules for PROTAC applications via ruthenium-catalysed C‒H amidation

Oxalate Oxidase for In Situ H 2 O 2 -Generation in Unspecific Peroxygenase-Catalysed Drug Oxyfunctionalisations

Ir III -Catalyzed Selective ortho-Monoiodination of Benzoic Acids with Unbiased C-H Bonds

Effects of mineral oil administration on the pharmacokinetics, metabolism and pharmacodynamics of atorvastatin and pravastatin in mice and dogs

Iridium-catalyzed C-H methylation and d 3 -methylation of benzoic acids with application to late-stage functionalizations

GPR103 Antagonists Demonstrating Anorexigenic Activity in Vivo: Design and Development of Pyrrolo[2,3‑c]pyridines That Mimic the C‑Terminal Arg-Phe Motif of QRFP26

Efficient DBU accelerated synthesis of 18 F-labelled trifluoroacetamides

Design and Optimization of Pyrazinecarboxamide-Based Inhibitors of Diacylglycerol Acyltransferase 1 (DGAT1) Leading to a Clinical Candidate Dimethylpyrazinecarboxamide Phenylcyclohexylacetic Acid (AZD7687)

Correction to GPR103 Antagonists Demonstrating Anorexigenic Activity in Vivo: Design and Development of Pyrrolo[2,3‑c]pyridines That Mimic the C‑Terminal Arg-Phe Motif of QRFP26

Uncatalyzed Diboron Activation by a Strained Hydrocarbon: Experimental and Theoretical Study of 1.1.1Propellane Diborylation

C–H activation

Cover Feature: IrIII‐Catalyzed Selective ortho‐Monoiodination of Benzoic Acids with Unbiased C−H Bonds (Chem. Eur. J. 45/2020)

Cover Feature: Ir III ‐Catalyzed Selective ortho ‐Monoiodination of Benzoic Acids with Unbiased C−H Bonds (Chem. Eur. J. 45/2020)

Oxalate Oxidase for In Situ H2 O2 -Generation in Unspecific Peroxygenase-Catalysed Drug Oxyfunctionalisations

Cover Feature: Electrochemical Proton Reduction over Nickel Foam for Z‐Stereoselective Semihydrogenation/deuteration of Functionalized Alkynes (ChemSusChem 1/2022)

Back Cover: General Cyclopropane Assembly by Enantioselective Transfer of a Redox‐Active Carbene to Aliphatic Olefins (Angew. Chem. Int. Ed. 18/2019)

Merging Directed C-H Activations with High-throughput Experimentation: Development of Predictable Iridium-catalyzed C-H Aminations Applicable to Late-stage Functionalizations

Efficient DBU accelerated synthesis of 18F-labelled trifluoroacetamidesElectronic supplementary information (ESI) available: Experimental procedures, characterization, radiochemistry and spectral data. See DOI: 10.1039/c6cc08535k

Oxalate Oxidase for In Situ H 2 O 2 ‐Generation in Unspecific Peroxygenase‐Catalysed Drug Oxyfunctionalisations

Nanopalladium-catalyzed conjugate reduction of Michael acceptors - application in flowElectronic supplementary information (ESI) available. See DOI: 10.1039/c5gc02920a

Efficient DBU accelerated synthesis of F-18-labelled trifluoroacetamides

Selective Heterogeneous C-H Activation/Halogenation Reactions Catalyzed by PdOF Nanocomposites

Rücktitelbild: General Cyclopropane Assembly by Enantioselective Transfer of a Redox‐Active Carbene to Aliphatic Olefins (Angew. Chem. 18/2019)

ChemInform Abstract: Scalable Synthesis of Piperazines Enabled by Visible‐Light Irradiation and Aluminum Organometallics

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