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HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

Journal of pharmacological and toxicological methods, 2011-01, Vol.63 (1), p.59-68

2011

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Glucosepane is a major protein cross-link of the senescent human extracellular matrix. Relationship with diabetes

The Journal of biological chemistry, 2005-04, Vol.280 (13), p.12310-12315

2005

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Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies

Journal of tissue engineering and regenerative medicine, 2015-09, Vol.9 (9), p.1017-1026

2015

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Biotransformation of diclofenac and effects on the metabolome of primary human hepatocytes upon repeated dose exposure

European journal of pharmaceutical sciences, 2012-04, Vol.45 (5), p.716-724

2012

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Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: Improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking

Diabetes (New York, N.Y.), 2005-02, Vol.54 (2), p.517-526

2005

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Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal

Archives of biochemistry and biophysics, 2002-06, Vol.402 (1), p.110-119

2002

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Comparison of in vitro thyroxine (T4) metabolism between Wistar rat and human hepatocyte cultures

Toxicology in vitro, 2024-04, Vol.96, p.105763-105763, Article 105763

2024

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Site-Specific Quantitative Evaluation of the Protein Glycation Product N6-(2,3-Dihydroxy-5,6-dioxohexyl)-l-lysinate by LC−(ESI)MS Peptide Mapping: Evidence for Its Key Role in AGE Formation

Bioconjugate chemistry, 2003-05, Vol.14 (3), p.619-628

2003

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Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies

Biotechnology and bioengineering, 2012-12, Vol.109 (12), p.3172-3181

2012

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Identification and quantification of major maillard cross-links in human serum albumin and lens protein. Evidence for glucosepane as the dominant compound

The Journal of biological chemistry, 2002-07, Vol.277 (28), p.24907-24915

2002

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Synthesis and Evaluation of Heteroaryl-Substituted Dihydronaphthalenes and Indenes: Potent and Selective Inhibitors of Aldosterone Synthase (CYP11B2) for the Treatment of Congestive Heart Failure and Myocardial Fibrosis

Journal of medicinal chemistry, 2006-04, Vol.49 (7), p.2222-2231

2006

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Formation pathways for lysine-arginine cross-links derived from hexoses and pentoses by Maillard processes: unraveling the structure of a pentosidine precursor

The Journal of biological chemistry, 2001-06, Vol.276 (26), p.23405-23412

2001

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Heteroaryl-Substituted Naphthalenes and Structurally Modified Derivatives: Selective Inhibitors of CYP11B2 for the Treatment of Congestive Heart Failure and Myocardial Fibrosis

Journal of medicinal chemistry, 2005-10, Vol.48 (21), p.6632-6642

2005

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Glucosepane Is a Major Protein Cross-link of the Senescent Human Extracellular Matrix

The Journal of biological chemistry, 2005-04, Vol.280 (13), p.12310-12315

2005

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Identification and Quantification of Major Maillard Cross-links in Human Serum Albumin and Lens Protein

The Journal of biological chemistry, 2002-07, Vol.277 (28), p.24907-24915

2002

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Paradoxical Effects of Green Tea (Camellia Sinensis) and Antioxidant Vitamins in Diabetic Rats

Diabetes (New York, N.Y.), 2005-02, Vol.54 (2), p.517-526

2005

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Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies: Serum-free culture of primary human hepatocyte bioreactor

Journal of tissue engineering and regenerative medicine, 2015-09, Vol.9 (9), p.1017-1026

2015

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Formation Pathways for Lysine-Arginine Cross-links Derived from Hexoses and Pentoses by Maillard Processes

The Journal of biological chemistry, 2001-06, Vol.276 (26), p.23405-23412

2001

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Novel 5α-Reductase Inhibitors: Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids

Journal of medicinal chemistry, 2006-01, Vol.49 (2), p.748-759

2006

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Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids

Journal of medicinal chemistry, 2006-01, Vol.49 (2), p.748-759

2006

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Unexpected Carbonyl Mobility in Aminoketoses: The Key to Major Maillard Crosslinks This work was supported by the Deutsche Forschungsgemeinschaft. We are grateful to S. Reeb, Institute of Chemistry, University of Hohenheim, as well as J. Rebell, Institute of Organic Chemistry, University of Stuttgart, for recording the NMR spectra

Angewandte Chemie International Edition, 2002-03, Vol.41 (5), p.801

2002

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Unerwartete Carbonyl-Mobilität in Aminoketosen: der Schlüssel zu wichtigen Maillard-Quervernetzungsprodukten

Angewandte Chemie, 2002-03, Vol.114 (5), p.826-828

2002

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Green Tea (Camellia sinensis) Ameliorates Retinopathy and Renal Mitochondrial Defects but Deteriorates Collagen Glycoxidation and Cross-Linking in Experimental Diabetes

Annals of the New York Academy of Sciences, 2005-06, Vol.1043 (1), p.940-940

2005

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Unerwartete Carbonyl‐Mobilität in Aminoketosen: der Schlüssel zu wichtigen Maillard‐Quervernetzungsprodukten

Angewandte Chemie, 2002-03, Vol.114 (5), p.826-828

2002

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Die Welt des Menschen -- Die Welt der Philosophie: Festschrift Für Jan Patočka

Biemel, Walter

Softcover reprint of the original 1st ed. 1976., 1976

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HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

Glucosepane is a major protein cross-link of the senescent human extracellular matrix. Relationship with diabetes

Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies

Biotransformation of diclofenac and effects on the metabolome of primary human hepatocytes upon repeated dose exposure

Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: Improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking

Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal

Comparison of in vitro thyroxine (T4) metabolism between Wistar rat and human hepatocyte cultures

Site-Specific Quantitative Evaluation of the Protein Glycation Product N6-(2,3-Dihydroxy-5,6-dioxohexyl)-l-lysinate by LC−(ESI)MS Peptide Mapping: Evidence for Its Key Role in AGE Formation

Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies

Identification and quantification of major maillard cross-links in human serum albumin and lens protein. Evidence for glucosepane as the dominant compound

Synthesis and Evaluation of Heteroaryl-Substituted Dihydronaphthalenes and Indenes: Potent and Selective Inhibitors of Aldosterone Synthase (CYP11B2) for the Treatment of Congestive Heart Failure and Myocardial Fibrosis

Formation pathways for lysine-arginine cross-links derived from hexoses and pentoses by Maillard processes: unraveling the structure of a pentosidine precursor

Heteroaryl-Substituted Naphthalenes and Structurally Modified Derivatives: Selective Inhibitors of CYP11B2 for the Treatment of Congestive Heart Failure and Myocardial Fibrosis

Glucosepane Is a Major Protein Cross-link of the Senescent Human Extracellular Matrix

Identification and Quantification of Major Maillard Cross-links in Human Serum Albumin and Lens Protein

Paradoxical Effects of Green Tea (Camellia Sinensis) and Antioxidant Vitamins in Diabetic Rats

Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies: Serum-free culture of primary human hepatocyte bioreactor

Formation Pathways for Lysine-Arginine Cross-links Derived from Hexoses and Pentoses by Maillard Processes

Novel 5α-Reductase Inhibitors: Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids

Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids

Unerwartete Carbonyl-Mobilität in Aminoketosen: der Schlüssel zu wichtigen Maillard-Quervernetzungsprodukten

Green Tea (Camellia sinensis) Ameliorates Retinopathy and Renal Mitochondrial Defects but Deteriorates Collagen Glycoxidation and Cross-Linking in Experimental Diabetes

Unerwartete Carbonyl‐Mobilität in Aminoketosen: der Schlüssel zu wichtigen Maillard‐Quervernetzungsprodukten

Die Welt des Menschen -- Die Welt der Philosophie: Festschrift Für Jan Patočka

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