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Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

The Journal of neuroscience, 2011-11, Vol.31 (46), p.16507-16516

2011

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Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.8076-8100

2021

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Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug–Drug Interaction Risk Profile

Journal of medicinal chemistry, 2022-03, Vol.65 (5), p.3786-3797

2022

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Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt)

Journal of medicinal chemistry, 2021-05, Vol.64 (9), p.5470-5484

2021

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Two Prodrugs of Potent and Selective GluR5 Kainate Receptor Antagonists Actives in Three Animal Models of Pain

Journal of medicinal chemistry, 2005-06, Vol.48 (13), p.4200-4203

2005

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Ethyl (3S,4aR,6S,8aR)-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester: A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine

Journal of medicinal chemistry, 2002-09, Vol.45 (20), p.4383-4386

2002

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Novel Potent 5-HT1F Receptor Agonists: Structure−Activity Studies of a Series of Substituted N-[3-(1-Methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides

Journal of medicinal chemistry, 2003-07, Vol.46 (14), p.3060-3071

2003

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Substituted furo[3,2- b]pyridines: novel bioisosteres of 5-HT 1F receptor agonists

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.167-170

2004

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Discovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT₁ F receptor agonists: Evolution from bicyclic to monocyclic cores

Bioorganic & medicinal chemistry letters, 2015-10, Vol.25 (19), p.4337-4341

2015

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Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides

Journal of medicinal chemistry, 2003-07, Vol.46 (14), p.3060-3071

2003

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Novel Potent 5-HT 1F Receptor Agonists: Structure−Activity Studies of a Series of Substituted N -[3-(1-Methyl-4-piperidinyl)-1 H -pyrrolo[3,2- b ]pyridin-5-yl]amides

Journal of medicinal chemistry, 2003-07, Vol.46 (14), p.3060-3071

2003

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Substituted Furo[3,2‐b]pyridines: Novel Bioisosteres of 5‐HT 1F Receptor Agonists

ChemInform, 2004-04, Vol.35 (17)

Mathes, Brian M.

2004

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A General Method for the Preparation of 2,3,5-Trisubstituted-furo[3,2-b]pyridines

ChemInform, 2003-05, Vol.34 (18), p.no-no

2003

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Substituted Furo[3,2-b]pyridines: Novel Bioisosteres of 5-HT1F Receptor Agonists

ChemInform, 2004-04, Vol.35 (17), p.no-no

2004

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Cyberchondria: Overlap with health anxiety and unique relations with impairment, quality of life, and service utilization

Psychiatry research, 2018-03, Vol.261, p.204-211

2018

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Alcohol consumption and dependence risk among male and female Veterans: Trajectories and predictors

Drug and alcohol dependence, 2024-04, Vol.257, p.111138-111138, Article 111138

2024

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Disturbance theory for ecosystem ecologists: A primer

Ecology and evolution, 2024-06, Vol.14 (6), p.e11403-n/a

2024

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Evaluating the long-term (Three Year) durability of brief interventions targeting risk factors for psychopathology

Journal of anxiety disorders, 2023-05, Vol.96, p.102710-102710, Article 102710

2023

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Importance of Incidental Findings in Preoperative Computed Tomography Angiography for Abdominally Based Free Flap Breast Reconstruction: A Multi-Institutional Study

Plastic and reconstructive surgery (1963), 2022-09, Vol.150 (3), p.527-535

2022

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How willing are you? Willingness as a predictor of change during treatment of adults with obsessive–compulsive disorder

Depression and anxiety, 2017-11, Vol.34 (11), p.1057-1064

2017

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Hostility and Suicide Risk Among Veterans: The Mediating Role of Perceived Burdensomeness

Cognitive therapy and research, 2020-06, Vol.44 (3), p.636-644

2020

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Validation of the distress tolerance scale‐short form in obsessive compulsive disorder

Journal of clinical psychology, 2018-06, Vol.74 (6), p.916-925

2018

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Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans

Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor

Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug–Drug Interaction Risk Profile

Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt)

Two Prodrugs of Potent and Selective GluR5 Kainate Receptor Antagonists Actives in Three Animal Models of Pain

Ethyl (3S,4aR,6S,8aR)-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester: A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine

Novel Potent 5-HT1F Receptor Agonists: Structure−Activity Studies of a Series of Substituted N-[3-(1-Methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides

Substituted furo[3,2- b]pyridines: novel bioisosteres of 5-HT 1F receptor agonists

Discovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT₁ F receptor agonists: Evolution from bicyclic to monocyclic cores

Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain : 2005 American Chemical Society Award for Computers in Chemical and Pharmaceutical Research

Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides

Novel Potent 5-HT 1F Receptor Agonists: Structure−Activity Studies of a Series of Substituted N -[3-(1-Methyl-4-piperidinyl)-1 H -pyrrolo[3,2- b ]pyridin-5-yl]amides

Ethyl (3S, 4aR, 6S, 8aR)-6-(4-ethoxycarbonylimidazol-1-ylmethyl)decahydroisoquinoline-3-c arboxylic ester: A prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine

Substituted Furo[3,2‐b]pyridines: Novel Bioisosteres of 5‐HT 1F Receptor Agonists

A General Method for the Preparation of 2,3,5-Trisubstituted-furo[3,2-b]pyridines

Substituted Furo[3,2-b]pyridines: Novel Bioisosteres of 5-HT1F Receptor Agonists

Cyberchondria: Overlap with health anxiety and unique relations with impairment, quality of life, and service utilization

Alcohol consumption and dependence risk among male and female Veterans: Trajectories and predictors

Disturbance theory for ecosystem ecologists: A primer

Evaluating the long-term (Three Year) durability of brief interventions targeting risk factors for psychopathology

Importance of Incidental Findings in Preoperative Computed Tomography Angiography for Abdominally Based Free Flap Breast Reconstruction: A Multi-Institutional Study

How willing are you? Willingness as a predictor of change during treatment of adults with obsessive–compulsive disorder

Hostility and Suicide Risk Among Veterans: The Mediating Role of Perceived Burdensomeness

Validation of the distress tolerance scale‐short form in obsessive compulsive disorder

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