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Novel 3-(pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile derivatives induce intrinsic and extrinsic apoptotic death mediated P53 in HCT116 colon carcinoma

Scientific reports, 2023-12, Vol.13 (1), p.22486-22486, Article 22486

2023

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Molecular Docking Study, Cytotoxicity, Cell Cycle Arrest and Apoptotic Induction of Novel Chalcones Incorporating Thiadiazolyl Isoquinoline in Cervical Cancer

Anti-cancer agents in medicinal chemistry, 2020-01, Vol.20 (1), p.70

2020

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Yttrium Oxide nanoparticles induce cytotoxicity, genotoxicity, apoptosis, and ferroptosis in the human triple-negative breast cancer MDA-MB-231 cells

BMC cancer, 2023-11, Vol.23 (1), p.1-1151, Article 1151

2023

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DNA Fragmentation, Cell Cycle Arrest, and Docking Study of Novel Bis Spiro-cyclic 2-oxindole of Pyrimido[4,5-b]quinoline-4,6-dione Derivatives Against Breast Carcinoma

Current cancer drug targets, 2018-05, Vol.18 (4), p.372

2018

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Novel Tetrahydro-[1,2,4]triazolo[3,4- a ]isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis

Molecules (Basel, Switzerland), 2023-04, Vol.28 (8), p.3338

2023

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Anticancer Activities of New N-hetaryl-2-cyanoacetamide Derivatives Incorporating 4,5,6,7-Tetrahydrobenzo[b]thiophene Moiety

Anti-cancer agents in medicinal chemistry, 2017-07, Vol.17 (8), p.1084

2017

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An overview on synthetic strategies for the construction of star-shaped molecules

RSC advances, 2019-05, Vol.9 (29), p.1666-16682

2019

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Synthesis, Cytotoxicity and Molecular Docking Simulation of Novel bis-1,4-Dihydropyridines Linked to Aliphatic or Arene Core via Amide or Ester-Amide Linkages

Mini reviews in medicinal chemistry, 2020-01, Vol.20 (9), p.801

2020

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Novel Scaffolds Based on Bis-thiazole Connected to Quinoxaline or Thienothiophene through 2-Phenoxy- N -arylacetamide Groups as New Hybrid Molecules: Synthesis, Antibacterial Activity, and Molecular Docking Investigations

ACS omega, 2023-11, Vol.8 (46), p.44312-44327

2023

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Recent Synthetic Approaches and Biological Evaluations of Amino Hexahydroquinolines and Their Spirocyclic Structures

Anti-cancer agents in medicinal chemistry, 2019-01, Vol.19 (7), p.875

2019

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New Azacycles by One‐Pot Three‐Component Hantzsch‐Like Synthesis of Tetra(hexa)azacyclopenta[a]anthracenes, Tetraazaindeno[5,4‐b]fluorenes, and Oxatetraazacyclopenta[m]tetraphenes

ChemistryOpen (Weinheim), 2023-03, Vol.12 (3), p.e202300009-n/a

2023

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Utility of 2‑Chloro‑N‑arylacetamide and 1,1′-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines]

ACS omega, 2024-03, Vol.9 (9), p.10146-10159

2024

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Novel hybrid thiazoles, bis-thiazoles linked to azo-sulfamethoxazole: Synthesis, docking, and antimicrobial activity

Heliyon, 2024-05, Vol.10 (10), p.e31082-e31082, Article e31082

2024

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Synthesis of Novel Diphenyl Ether-Based Bis-Heterocycles as Novel Hybrid Molecules via Michael and Other Cyclocondensation Reactions

ACS omega, 2024-01, Vol.9 (3), p.4073-4084

2024

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Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer

Chemico-biological interactions, 2023-01, Vol.369, p.110297-110297, Article 110297

2023

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Synthesis, characterization and antimicrobial activity of a novel chitosan Schiff bases based on heterocyclic moieties

International journal of biological macromolecules, 2020-06, Vol.153, p.492-501

2020

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Cytotoxicity, molecular modeling, cell cycle arrest, and apoptotic induction induced by novel tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline chalcones

European journal of medicinal chemistry, 2018-01, Vol.143, p.532-541

2018

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[1,2,4] Triazolo [3,4-a]isoquinoline chalcone derivative exhibits anticancer activity via induction of oxidative stress, DNA damage, and apoptosis in Ehrlich solid carcinoma-bearing mice

Naunyn-Schmiedeberg's archives of pharmacology, 2022-10, Vol.395 (10), p.1225-1238

2022

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Synthesis of novel chitosan-Schiff bases nanoparticles for high efficiency Helicobacter pylori inhibition

International journal of biological macromolecules, 2024-08, Vol.274 (Pt 2), p.133499, Article 133499

2024

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Novel 2‐cyanoacrylamido‐4,5,6,7‐tetrahydrobenzo[b]thiophene derivatives as potent anticancer agents

Archiv der Pharmazie (Weinheim), 2020-10, Vol.353 (10), p.e2000069-n/a

2020

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Recent advances in the functionalization of azulene through Rh‐, Ir‐, Ru‐, Au‐, Fe‐, Ni‐, and Cu‐catalyzed reactions

Applied organometallic chemistry, 2022-08, Vol.36 (8), p.n/a

2022

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Anticancer behaviour of 2,2′-(pyridin-2-ylmethylene)bis(5,5-dimethylcyclohexane-1,3-dione)-based palladium(II) complex and its DNA, BSA binding propensity and DFT study

Journal of inorganic biochemistry, 2024-04, Vol.253, p.112488-112488, Article 112488

2024

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Synthesis, anticancer evaluation of novel hybrid pyrazole-based chalcones, molecular docking, DNA fragmentation, and gene expression: in vitro studies

RSC advances, 2024-07, Vol.14 (30), p.21859-21873

2024

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Synthesis, cytotoxicity, anti-inflammatory, anti-metastatic and anti-oxidant activities of novel chalcones incorporating 2-phenoxy-N-arylacetamide and thiophene moieties: induction of apoptosis in MCF7 and HEP2 cells

Naunyn-Schmiedeberg's archives of pharmacology, 2024-07

2024

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Novel eco-friendly [1,2,4]triazolo[3,4-a]isoquinoline chalcone derivatives efficiency against fungal deterioration of ancient Egyptian mummy cartonnage, Egypt

Archives of microbiology, 2023-02, Vol.205 (2), p.57-57, Article 57

2023

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Novel 3-(pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile derivatives induce intrinsic and extrinsic apoptotic death mediated P53 in HCT116 colon carcinoma

Molecular Docking Study, Cytotoxicity, Cell Cycle Arrest and Apoptotic Induction of Novel Chalcones Incorporating Thiadiazolyl Isoquinoline in Cervical Cancer

Yttrium Oxide nanoparticles induce cytotoxicity, genotoxicity, apoptosis, and ferroptosis in the human triple-negative breast cancer MDA-MB-231 cells

DNA Fragmentation, Cell Cycle Arrest, and Docking Study of Novel Bis Spiro-cyclic 2-oxindole of Pyrimido[4,5-b]quinoline-4,6-dione Derivatives Against Breast Carcinoma

Novel Tetrahydro-[1,2,4]triazolo[3,4- a ]isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis

Anticancer Activities of New N-hetaryl-2-cyanoacetamide Derivatives Incorporating 4,5,6,7-Tetrahydrobenzo[b]thiophene Moiety

An overview on synthetic strategies for the construction of star-shaped molecules

Synthesis, Cytotoxicity and Molecular Docking Simulation of Novel bis-1,4-Dihydropyridines Linked to Aliphatic or Arene Core via Amide or Ester-Amide Linkages

Novel Scaffolds Based on Bis-thiazole Connected to Quinoxaline or Thienothiophene through 2-Phenoxy- N -arylacetamide Groups as New Hybrid Molecules: Synthesis, Antibacterial Activity, and Molecular Docking Investigations

Recent Synthetic Approaches and Biological Evaluations of Amino Hexahydroquinolines and Their Spirocyclic Structures

New Azacycles by One‐Pot Three‐Component Hantzsch‐Like Synthesis of Tetra(hexa)azacyclopenta[a]anthracenes, Tetraazaindeno[5,4‐b]fluorenes, and Oxatetraazacyclopenta[m]tetraphenes

Utility of 2‑Chloro‑N‑arylacetamide and 1,1′-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines]

Novel hybrid thiazoles, bis-thiazoles linked to azo-sulfamethoxazole: Synthesis, docking, and antimicrobial activity

Synthesis of Novel Diphenyl Ether-Based Bis-Heterocycles as Novel Hybrid Molecules via Michael and Other Cyclocondensation Reactions

Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer

Synthesis, characterization and antimicrobial activity of a novel chitosan Schiff bases based on heterocyclic moieties

Cytotoxicity, molecular modeling, cell cycle arrest, and apoptotic induction induced by novel tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline chalcones

[1,2,4] Triazolo [3,4-a]isoquinoline chalcone derivative exhibits anticancer activity via induction of oxidative stress, DNA damage, and apoptosis in Ehrlich solid carcinoma-bearing mice

Synthesis of novel chitosan-Schiff bases nanoparticles for high efficiency Helicobacter pylori inhibition

Novel 2‐cyanoacrylamido‐4,5,6,7‐tetrahydrobenzo[b]thiophene derivatives as potent anticancer agents

Recent advances in the functionalization of azulene through Rh‐, Ir‐, Ru‐, Au‐, Fe‐, Ni‐, and Cu‐catalyzed reactions

Anticancer behaviour of 2,2′-(pyridin-2-ylmethylene)bis(5,5-dimethylcyclohexane-1,3-dione)-based palladium(II) complex and its DNA, BSA binding propensity and DFT study

Synthesis, anticancer evaluation of novel hybrid pyrazole-based chalcones, molecular docking, DNA fragmentation, and gene expression: in vitro studies

Synthesis, cytotoxicity, anti-inflammatory, anti-metastatic and anti-oxidant activities of novel chalcones incorporating 2-phenoxy-N-arylacetamide and thiophene moieties: induction of apoptosis in MCF7 and HEP2 cells

Novel eco-friendly [1,2,4]triazolo[3,4-a]isoquinoline chalcone derivatives efficiency against fungal deterioration of ancient Egyptian mummy cartonnage, Egypt

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