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A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design

Journal of medicinal chemistry, 2015-06, Vol.58 (11), p.4383-4438

2015

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Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study

PloS one, 2019-10, Vol.14 (10), p.e0224076

2019

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A Small Molecule Inhibitor Selectively Induces Apoptosis in Cells Transformed by High Risk Human Papilloma Viruses

PloS one, 2016-06, Vol.11 (6), p.e0155909-e0155909

2016

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Epitope and Paratope Mapping of PD-1/Nivolumab by Mass Spectrometry-Based Hydrogen–Deuterium Exchange, Cross-linking, and Molecular Docking

Analytical chemistry (Washington), 2020-07, Vol.92 (13), p.9086-9094

2020

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Ligand-induced changes in hepatitis C virus NS5B polymerase structure

Antiviral research, 2010-11, Vol.88 (2), p.197-206

2010

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An Integrated Approach for Determining a Protein–Protein Binding Interface in Solution and an Evaluation of Hydrogen–Deuterium Exchange Kinetics for Adjudicating Candidate Docking Models

Analytical chemistry (Washington), 2019-12, Vol.91 (24), p.15709-15717

2019

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Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.2925-2929

2011

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Atropisomerism Observed in Galactose-Based Monosaccharide Inhibitors of Galectin‑3 Comprising 2‑Methyl-4-phenyl-2,4-dihydro‑3H‑1,2,4-triazole-3-thione

Journal of medicinal chemistry, 2024-08, Vol.67 (16), p.14184-14199

2024

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Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL‑6 Receptor upon Binding of Protein Therapeutics

Analytical chemistry (Washington), 2017-07, Vol.89 (14), p.7742-7749

2017

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Synthesis, Structure–Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin‑3 Inhibitors

Journal of medicinal chemistry, 2021-05, Vol.64 (10), p.6634-6655

2021

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Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: Potent allosteric inhibitors of the hepatitis C virus NS5B polymerase

Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (8), p.2866-2871

2012

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High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus

PloS one, 2012-08, Vol.7 (8), p.e42609-e42609

2012

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Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition

Bioorganic & medicinal chemistry letters, 2021-03, Vol.36, p.127823-127823, Article 127823

2021

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Hydrogen-Deuterium Exchange and Hydroxyl Radical Footprinting for Mapping Hydrophobic Interactions of Human Bromodomain with a Small Molecule Inhibitor

Journal of the American Society for Mass Spectrometry, 2019-12, Vol.30 (12), p.2795-2804

2019

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Conformationally Restricted Homotryptamines. Part 7: 3-cis-(3-Aminocyclopentyl)indoles As Potent Selective Serotonin Reuptake Inhibitors

Journal of medicinal chemistry, 2010-11, Vol.53 (21), p.7564-7572

2010

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Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1855-1879

2014

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Discovery and exploration of monosaccharide linked dimers of galectin-3 inhibitors to target fibrosis

Medicinal chemistry research, 2023-07, Vol.32 (7), p.1453-1480

2023

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Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity

The Journal of pharmacology and experimental therapeutics, 2015-09, Vol.354 (3), p.340-349

2015

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A Becke3LYP/6-31G Study of the Cope Rearrangements of Substituted 1,5-Hexadienes Provides Computational Evidence for a Chameleonic Transition State

Journal of the American Chemical Society, 1999-11, Vol.121 (45), p.10529-10537

1999

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An Antibody exo Diels-Alderase Inhibitor Complex at 1.95 Angstrom Resolution

Science (American Association for the Advancement of Science), 1998-03, Vol.279 (5358), p.1934-1940

1998

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Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2017-01, Vol.27 (2), p.295-298

2017

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C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors

Bioorganic & medicinal chemistry, 2016-04, Vol.24 (8), p.1757-1770

2016

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Conformationally Restricted Homotryptamines. 2. Indole Cyclopropylmethylamines as Selective Serotonin Reuptake Inhibitors

Journal of medicinal chemistry, 2005-09, Vol.48 (19), p.6023-6034

2005

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Discovery of BMS-955176, a Second Generation HIV‑1 Maturation Inhibitor with Broad Spectrum Antiviral Activity

ACS medicinal chemistry letters, 2016-06, Vol.7 (6), p.568-572

2016

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A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design

Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study

Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies

A Small Molecule Inhibitor Selectively Induces Apoptosis in Cells Transformed by High Risk Human Papilloma Viruses

Epitope and Paratope Mapping of PD-1/Nivolumab by Mass Spectrometry-Based Hydrogen–Deuterium Exchange, Cross-linking, and Molecular Docking

Ligand-induced changes in hepatitis C virus NS5B polymerase structure

An Integrated Approach for Determining a Protein–Protein Binding Interface in Solution and an Evaluation of Hydrogen–Deuterium Exchange Kinetics for Adjudicating Candidate Docking Models

Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus

Atropisomerism Observed in Galactose-Based Monosaccharide Inhibitors of Galectin‑3 Comprising 2‑Methyl-4-phenyl-2,4-dihydro‑3H‑1,2,4-triazole-3-thione

Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL‑6 Receptor upon Binding of Protein Therapeutics

Synthesis, Structure–Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin‑3 Inhibitors

Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: Potent allosteric inhibitors of the hepatitis C virus NS5B polymerase

High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus

Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition

Hydrogen-Deuterium Exchange and Hydroxyl Radical Footprinting for Mapping Hydrophobic Interactions of Human Bromodomain with a Small Molecule Inhibitor

Conformationally Restricted Homotryptamines. Part 7: 3-cis-(3-Aminocyclopentyl)indoles As Potent Selective Serotonin Reuptake Inhibitors

Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase

Discovery and exploration of monosaccharide linked dimers of galectin-3 inhibitors to target fibrosis

Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity

A Becke3LYP/6-31G Study of the Cope Rearrangements of Substituted 1,5-Hexadienes Provides Computational Evidence for a Chameleonic Transition State

An Antibody exo Diels-Alderase Inhibitor Complex at 1.95 Angstrom Resolution

Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors

Conformationally Restricted Homotryptamines. 2. Indole Cyclopropylmethylamines as Selective Serotonin Reuptake Inhibitors

Discovery of BMS-955176, a Second Generation HIV‑1 Maturation Inhibitor with Broad Spectrum Antiviral Activity

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