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Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (29), p.E2724-E2732

2013

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Neonicotinoid insecticides induce salicylate-associated plant defense responses

Proceedings of the National Academy of Sciences - PNAS, 2010-10, Vol.107 (41), p.17527-17532

2010

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Yersiniabactin contributes to overcoming zinc restriction during Yersinia pestis infection of mammalian and insect hosts

Proceedings of the National Academy of Sciences - PNAS, 2021-11, Vol.118 (44), p.1-10

2021

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A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives

Proceedings of the National Academy of Sciences - PNAS, 2022-04, Vol.119 (15), p.e2122512119-e2122512119

2022

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Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (26), p.10830-10835

2013

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Bladder drug mirabegron exacerbates atherosclerosis through activation of brown fat-mediated lipolysis

Proceedings of the National Academy of Sciences - PNAS, 2019-05, Vol.116 (22), p.10937-10942

2019

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Drug resistance confounding prion therapeutics

Proceedings of the National Academy of Sciences - PNAS, 2013-10, Vol.110 (44), p.E4160-E4169

2013

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Rad52 inactivation is synthetically lethal with BRCA2 deficiency

Proceedings of the National Academy of Sciences - PNAS, 2011-01, Vol.108 (2), p.686-691

2011

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MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (25), p.10258-10263

2013

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Selective Small-Molecule Inhibitor Reveals Critical Mitotic Functions of Human CDK1

Proceedings of the National Academy of Sciences - PNAS, 2006-07, Vol.103 (28), p.10660-10665

2006

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small molecule accelerates neuronal differentiation in the adult rat

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (38), p.16542-16547

2010

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Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist

Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (21), p.E1369-E1376

2012

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Selective inhibition of CD4⁺ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2012-09, Vol.109 (36), p.14532-14537

2012

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Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (34), p.12468-12473

2014

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Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway

Proceedings of the National Academy of Sciences - PNAS, 2008-04, Vol.105 (17), p.6302-6307

2008

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Stimulation of Mammalian Translation Initiation Factor eIF4A Activity by a Small Molecule Inhibitor of Eukaryotic Translation

Proceedings of the National Academy of Sciences - PNAS, 2005-07, Vol.102 (30), p.10460-10465

2005

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Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib

Proceedings of the National Academy of Sciences - PNAS, 2007-08, Vol.104 (33), p.13283-13288

2007

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Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

Proceedings of the National Academy of Sciences - PNAS, 2008-10, Vol.105 (43), p.16809-16813

2008

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Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (11), p.4227-4232

2014

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Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

Proceedings of the National Academy of Sciences - PNAS, 2003-12, Vol.100 (26), p.15924-15929

2003

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Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels

Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (21), p.8732-8737

2013

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Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway

Proceedings of the National Academy of Sciences - PNAS, 2010-07, Vol.107 (29), p.12828-12833

2010

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A Selective Peroxisome Proliferator-Activated Receptor δ Agonist Promotes Reverse Cholesterol Transport

Proceedings of the National Academy of Sciences - PNAS, 2001-04, Vol.98 (9), p.5306-5311

2001

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DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice

Proceedings of the National Academy of Sciences - PNAS, 2015-07, Vol.112 (27), p.8385-8390

2015

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Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans

Proceedings of the National Academy of Sciences - PNAS, 2011-08, Vol.108 (32), p.13053-13058

2011

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Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Neonicotinoid insecticides induce salicylate-associated plant defense responses

Yersiniabactin contributes to overcoming zinc restriction during Yersinia pestis infection of mammalian and insect hosts

A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives

Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor

Bladder drug mirabegron exacerbates atherosclerosis through activation of brown fat-mediated lipolysis

Drug resistance confounding prion therapeutics

Rad52 inactivation is synthetically lethal with BRCA2 deficiency

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

Selective Small-Molecule Inhibitor Reveals Critical Mitotic Functions of Human CDK1

small molecule accelerates neuronal differentiation in the adult rat

Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist

Selective inhibition of CD4⁺ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells

Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway

Stimulation of Mammalian Translation Initiation Factor eIF4A Activity by a Small Molecule Inhibitor of Eukaryotic Translation

Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels

Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway

A Selective Peroxisome Proliferator-Activated Receptor δ Agonist Promotes Reverse Cholesterol Transport

DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice

Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans

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