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MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

PLoS biology, 2019-09, Vol.17 (9), p.e3000354-e3000354

2019

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Selective activation of PFKL suppresses the phagocytic oxidative burst

Cell, 2021-08, Vol.184 (17), p.4480-4494.e15

2021

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Identifying transcriptional programs underlying cancer drug response with TraCe-seq

Nature biotechnology, 2022-01, Vol.40 (1), p.86-93

2022

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Targeted degradation via direct 26S proteasome recruitment

Nature chemical biology, 2023-01, Vol.19 (1), p.55-63

2023

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RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy

Cancer discovery, 2022-01, Vol.12 (1), p.204-219

2022

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Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

PLoS biology, 2019-10, Vol.17 (10), p.e3000529-e3000529

2019

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Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation

Cell chemical biology, 2023-02, Vol.30 (2), p.175-187.e15

2023

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A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands

Biochemistry (Easton), 2023-02, Vol.62 (3), p.633-644

2023

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The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site

Structure (London), 2012-10, Vol.20 (10), p.1704-1714

2012

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Abstract DDT02-01: Discovery of GDC-0077, a highly isoform selective inhibitor of PI3Kα that promotes selective loss of mutant-p110α

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.DDT02-01-DDT02-01

Staben, Steven T.

2017

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A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands

Biochemistry (Easton), 2022-01, Vol.62 (3)

2022

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Abstract PR03: Selective degradation of mutant PIK3CA promotes increased mutant specificity in a subset of PI3K ATP-competitive inhibitors

Molecular cancer research, 2020-10, Vol.18 (10_Supplement), p.PR03-PR03

2020

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Isoform Selective PI3K Inhibitors for Treating Cancer

Cancer II, p.333-333

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Abstract 156: Preclinical characterization of GDC-0077, a specific PI3K alpha inhibitor in early clinical development

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.156-156

2017

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Four‐Component Synthesis of Fully Substituted 1,2,4‐Triazoles

Angewandte Chemie, 2010-01, Vol.122 (2), p.335-338

2010

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Selective inhibition of NF-kB inducing kinase (NIK) is therapeutically efficacious in IFNα-accelerated lupus nephritis prone mice

The Journal of immunology (1950), 2017-05, Vol.198 (1_Supplement), p.217-217.4

2017

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Abstract A067: Targeting p21-activated kinases in breast cancer

Molecular cancer research, 2013-10, Vol.11 (10_Supplement), p.A067-A067

2013

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Four-Component Synthesis of Fully Substituted 1,2,4-Triazoles

Angewandte Chemie, 2010-01, Vol.122 (2), p.335-338

2010

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Abstract DDT02-01: Discovery of GDC-0032: A beta-sparing PI3K inhibitor active against PIK3CA mutant tumors

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.DDT02-01-DDT02-01

2013

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ChemInform Abstract: Heteroarylation of Azine N-Oxides

ChemInform, 2012-06, Vol.43 (24), p.no-no

2012

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Potent and selective inhibitors of PI3KI': Obtaining isoform selectivity from the affinity pocket and tryptophan shelf

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (13), p.4296-4302

2012

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Gold(I)-Catalyzed Cyclizations of Silyl Enol Ethers: Application to the Synthesis of (+)-Lycopladine A

Angewandte Chemie, 2006-09, Vol.118 (36), p.6137-6140

2006

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Gold( I )‐Catalyzed 5‐ endo ‐ dig Carbocyclization of Acetylenic Dicarbonyl Compounds

Angewandte Chemie, 2004-10, Vol.116 (40), p.5464-5466

2004

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MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

Selective activation of PFKL suppresses the phagocytic oxidative burst

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

Identifying transcriptional programs underlying cancer drug response with TraCe-seq

Targeted degradation via direct 26S proteasome recruitment

RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy

Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation

A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands

The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site

Abstract DDT02-01: Discovery of GDC-0077, a highly isoform selective inhibitor of PI3Kα that promotes selective loss of mutant-p110α

Overcoming Preclinical Safety Obstacles to Discover ( S )- N -((1,2,3,5,6,7-Hexahydro- s -indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5 H -pyrazolo[5,1- b ][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor

A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands

Abstract PR03: Selective degradation of mutant PIK3CA promotes increased mutant specificity in a subset of PI3K ATP-competitive inhibitors

Isoform Selective PI3K Inhibitors for Treating Cancer

Abstract 156: Preclinical characterization of GDC-0077, a specific PI3K alpha inhibitor in early clinical development

Four‐Component Synthesis of Fully Substituted 1,2,4‐Triazoles

Selective inhibition of NF-kB inducing kinase (NIK) is therapeutically efficacious in IFNα-accelerated lupus nephritis prone mice

Abstract A067: Targeting p21-activated kinases in breast cancer

Four-Component Synthesis of Fully Substituted 1,2,4-Triazoles

Abstract DDT02-01: Discovery of GDC-0032: A beta-sparing PI3K inhibitor active against PIK3CA mutant tumors

ChemInform Abstract: Heteroarylation of Azine N-Oxides

Potent and selective inhibitors of PI3KI': Obtaining isoform selectivity from the affinity pocket and tryptophan shelf

Gold(I)-Catalyzed Cyclizations of Silyl Enol Ethers: Application to the Synthesis of (+)-Lycopladine A

Gold( I )‐Catalyzed 5‐ endo ‐ dig Carbocyclization of Acetylenic Dicarbonyl Compounds

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