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Identifying ligands at orphan GPCRs: current status using structure‐based approaches

British journal of pharmacology, 2016-10, Vol.173 (20), p.2934-2951

2016

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Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity

PLoS biology, 2020-04, Vol.18 (4), p.e3000656-e3000656

2020

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A circuit for secretion‐coupled cellular autonomy in multicellular eukaryotic cells

Molecular systems biology, 2023-04, Vol.19 (4), p.e11127-n/a

2023

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Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity

Science signaling, 2016-04, Vol.9 (423), p.ra36

2016

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Analysis of drug binding pockets and repurposing opportunities for twelve essential enzymes of ESKAPE pathogens

PeerJ (San Francisco, CA), 2017-09, Vol.5, p.e3765-e3765, Article e3765

2017

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Rapid Knockout and Reporter Mouse Line Generation and Breeding Colony Establishment Using EUCOMM Conditional-Ready Embryonic Stem Cells: A Case Study

Frontiers in endocrinology (Lausanne), 2015-06, Vol.6, p.105-105

2015

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Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control

Biology of sex differences, 2018-04, Vol.9 (1), p.14-14, Article 14

2018

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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

British journal of pharmacology, 2021-10, Vol.178 (S1), p.S27-S156

2021

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Ponesimod inhibits astrocyte‐mediated neuroinflammation and protects against cingulum demyelination via S1P1‐selective modulation

The FASEB journal, 2022-02, Vol.36 (2), p.e22132-n/a

2022

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Impulse Oscillometry to Evaluate Lung Function in Young Children Under Five Years with Sickle Cell Disease

Blood, 2019-11, Vol.134 (Supplement_1), p.4853-4853

2019

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Ponesimod inhibits astrocyte-mediated neuroinflammation and protects against cingulum demyelination via S1P 1 -selective modulation

The FASEB journal, 2022-02, Vol.36 (2), p.e22132

2022

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The G protein-coupled receptor N-terminus and receptor signalling: N-tering a new era

Cellular signalling, 2017-05, Vol.33, p.1-9

2017

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Structural basis for GPCR-independent activation of heterotrimeric Gi proteins

Proceedings of the National Academy of Sciences - PNAS, 2019-08, Vol.116 (33), p.16394-16403

2019

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Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi

Proceedings of the National Academy of Sciences - PNAS, 2020-11, Vol.117 (46), p.28763-28774

2020

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A long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding

The Journal of biological chemistry, 2021-01, Vol.296, p.100493-100493, Article 100493

2021

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Orphan receptor ligand discovery by pickpocketing pharmacological neighbors

Nature chemical biology, 2017-02, Vol.13 (2), p.235

2017

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Functionally Discrete Mimics of Light-activated Rhodopsin Identified through Expression of Soluble Cytoplasmic Domains

The Journal of biological chemistry, 2000-12, Vol.275 (50), p.39354-39363

2000

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The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases

Scientific reports, 2020-11, Vol.10 (1), p.19995-19995, Article 19995

2020

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Structure and Signaling Mechanisms of G Protein‐Coupled and b‐Arrestin‐Biased Chemokine Receptors

The FASEB journal, 2018-04, Vol.32 (S1), p.382.3-382.3

2018

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Improving Worker Safety for Handling Nanomaterials at the Benchtop

Microscopy and microanalysis, 2016-07, Vol.22 (S3), p.2050-2051

2016

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The Receptor-Bound “Empty Pocket” State of the Heterotrimeric G-Protein α-Subunit Is Conformationally Dynamic

Biochemistry (Easton), 2006-10, Vol.45 (43), p.12986-12997

2006

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5-HT^sub 1A^ receptor pharmacophores to screen for off-target activity of [alpha]^sub 1^-adrenoceptor antagonists

Journal of computer-aided molecular design, 2013-04, Vol.27 (4), p.305

2013

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5-HT sub(1A) receptor pharmacophores to screen for off-target activity of alpha sub(1)-adrenoceptor antagonists

Journal of computer-aided molecular design, 2013-04, Vol.27 (4), p.305-319

2013

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One-step purification of a functional, constitutively activated form of visual arrestin

Protein expression and purification, 2012-03, Vol.82 (1), p.55-60

2012

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Folding and Assembly in Rhodopsin

The Journal of biological chemistry, 1999-07, Vol.274 (30), p.21437-21442

1999

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Identifying ligands at orphan GPCRs: current status using structure‐based approaches

Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity

A circuit for secretion‐coupled cellular autonomy in multicellular eukaryotic cells

Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity

Analysis of drug binding pockets and repurposing opportunities for twelve essential enzymes of ESKAPE pathogens

Rapid Knockout and Reporter Mouse Line Generation and Breeding Colony Establishment Using EUCOMM Conditional-Ready Embryonic Stem Cells: A Case Study

Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

Ponesimod inhibits astrocyte‐mediated neuroinflammation and protects against cingulum demyelination via S1P1‐selective modulation

Impulse Oscillometry to Evaluate Lung Function in Young Children Under Five Years with Sickle Cell Disease

Ponesimod inhibits astrocyte-mediated neuroinflammation and protects against cingulum demyelination via S1P 1 -selective modulation

The G protein-coupled receptor N-terminus and receptor signalling: N-tering a new era

Structural basis for GPCR-independent activation of heterotrimeric Gi proteins

Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi

A long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding

Orphan receptor ligand discovery by pickpocketing pharmacological neighbors

Functionally Discrete Mimics of Light-activated Rhodopsin Identified through Expression of Soluble Cytoplasmic Domains

The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases

Structure and Signaling Mechanisms of G Protein‐Coupled and b‐Arrestin‐Biased Chemokine Receptors

Improving Worker Safety for Handling Nanomaterials at the Benchtop

The Receptor-Bound “Empty Pocket” State of the Heterotrimeric G-Protein α-Subunit Is Conformationally Dynamic

5-HT^sub 1A^ receptor pharmacophores to screen for off-target activity of [alpha]^sub 1^-adrenoceptor antagonists

5-HT sub(1A) receptor pharmacophores to screen for off-target activity of alpha sub(1)-adrenoceptor antagonists

One-step purification of a functional, constitutively activated form of visual arrestin

Folding and Assembly in Rhodopsin

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