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Very long-chain fatty acids: elongation, physiology and related disorders

Journal of biochemistry (Tokyo), 2012-11, Vol.152 (5), p.387-395

Kihara, Akio

2012

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Very long‐chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice

The FASEB journal, 2018-06, Vol.32 (6), p.2966-2978

2018

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Enzyme Activities of the Ceramide Synthases CERS2–6 Are Regulated by Phosphorylation in the C-terminal Region

The Journal of biological chemistry, 2016-04, Vol.291 (14), p.7477-7487

2016

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Formation of fatty alcohols—components of meibum lipids—by the fatty acyl‐CoA reductase FAR2 is essential for dry eye prevention

The FASEB journal, 2022-04, Vol.36 (4), p.e22216-n/a

2022

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ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis

Proceedings of the National Academy of Sciences - PNAS, 2010-10, Vol.107 (43), p.18439-18444

2010

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Membrane Protein Rim21 Plays a Central Role in Sensing Ambient pH in Saccharomyces cerevisiae

The Journal of biological chemistry, 2012-11, Vol.287 (46), p.38473-38481

2012

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Dual Functions of the Trans-2-Enoyl-CoA Reductase TER in the Sphingosine 1-Phosphate Metabolic Pathway and in Fatty Acid Elongation

The Journal of biological chemistry, 2014-09, Vol.289 (36), p.24736-24748

2014

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The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways

The Journal of biological chemistry, 2017-09, Vol.292 (37), p.15538-15551

2017

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Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system

Molecular biology of the cell, 2012-12, Vol.23 (23), p.4543-4551

2012

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Sphingolipids activate the endoplasmic reticulum stress surveillance pathway

The Journal of cell biology, 2018-02, Vol.217 (2), p.495-505

2018

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Loop 5 region is important for the activity of the long-chain base transporter Rsb1

Journal of biochemistry (Tokyo), 2017-02, Vol.161 (2), p.207-213

2017

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A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC)

Molecular biology of the cell, 2016-02, Vol.27 (3), p.491-499

2016

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The C-terminal Cytosolic Region of Rim21 Senses Alterations in Plasma Membrane Lipid Composition

The Journal of biological chemistry, 2015-12, Vol.290 (52), p.30797-30805

2015

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Congenital myopathy is caused by mutation of HACD1

Human molecular genetics, 2013-12, Vol.22 (25), p.5229-5236

2013

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Mutation for Nonsyndromic Mental Retardation in the trans-2-Enoyl-CoA Reductase TER Gene Involved in Fatty Acid Elongation Impairs the Enzyme Activity and Stability, Leading to Change in Sphingolipid Profile

The Journal of biological chemistry, 2013-12, Vol.288 (51), p.36741-36749

2013

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Mouse Sphingosine Kinase Isoforms SPHK1a and SPHK1b Differ in Enzymatic Traits Including Stability, Localization, Modification, and Oligomerization

The Journal of biological chemistry, 2006-02, Vol.281 (7), p.4532-4539

2006

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Cross talk between sphingolipids and glycerophospholipids in the establishment of plasma membrane asymmetry

Molecular biology of the cell, 2004-11, Vol.15 (11), p.4949-4959

2004

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The Rim101 pathway is involved in Rsb1 expression induced by altered lipid asymmetry

Molecular biology of the cell, 2008-05, Vol.19 (5), p.1922-1931

2008

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FVT-1 Is a Mammalian 3-Ketodihydrosphingosine Reductase with an Active Site That Faces the Cytosolic Side of the Endoplasmic Reticulum Membrane

The Journal of biological chemistry, 2004-11, Vol.279 (47), p.49243-49250

2004

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Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress

Proceedings of the National Academy of Sciences - PNAS, 2014-02, Vol.111 (8), p.3080-3085

2014

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Identification and Characterization of a Novel Human Sphingosine-1-phosphate Phosphohydrolase, hSPP2

The Journal of biological chemistry, 2003-01, Vol.278 (2), p.1268-1272

2003

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Membrane Topology and Essential Amino Acid Residues of Phs1, a 3-Hydroxyacyl-CoA Dehydratase Involved in Very Long-chain Fatty Acid Elongation

The Journal of biological chemistry, 2008-04, Vol.283 (17), p.11199-11209

2008

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Feedback Inactivation of D-Serine Synthesis by NMDA Receptor-Elicited Translocation of Serine Racemase to the Membrane

Proceedings of the National Academy of Sciences - PNAS, 2009-05, Vol.106 (18), p.7589-7594

2009

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Lysophosphatidic Acid 2 Receptor-mediated Supramolecular Complex Formation Regulates Its Antiapoptotic Effect

The Journal of biological chemistry, 2009-05, Vol.284 (21), p.14558-14571

2009

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Role of 2-hydroxy acyl-CoA lyase HACL2 in odd-chain fatty acid production via α-oxidation in vivo

Molecular biology of the cell, 2023-08, Vol.34 (9), p.ar85-ar85

2023

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Very long-chain fatty acids: elongation, physiology and related disorders

Very long‐chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice

Enzyme Activities of the Ceramide Synthases CERS2–6 Are Regulated by Phosphorylation in the C-terminal Region

Formation of fatty alcohols—components of meibum lipids—by the fatty acyl‐CoA reductase FAR2 is essential for dry eye prevention

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis

Membrane Protein Rim21 Plays a Central Role in Sensing Ambient pH in Saccharomyces cerevisiae

Dual Functions of the Trans-2-Enoyl-CoA Reductase TER in the Sphingosine 1-Phosphate Metabolic Pathway and in Fatty Acid Elongation

The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways

Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system

Sphingolipids activate the endoplasmic reticulum stress surveillance pathway

Loop 5 region is important for the activity of the long-chain base transporter Rsb1

A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC)

The C-terminal Cytosolic Region of Rim21 Senses Alterations in Plasma Membrane Lipid Composition

Congenital myopathy is caused by mutation of HACD1

Mutation for Nonsyndromic Mental Retardation in the trans-2-Enoyl-CoA Reductase TER Gene Involved in Fatty Acid Elongation Impairs the Enzyme Activity and Stability, Leading to Change in Sphingolipid Profile

Mouse Sphingosine Kinase Isoforms SPHK1a and SPHK1b Differ in Enzymatic Traits Including Stability, Localization, Modification, and Oligomerization

Cross talk between sphingolipids and glycerophospholipids in the establishment of plasma membrane asymmetry

The Rim101 pathway is involved in Rsb1 expression induced by altered lipid asymmetry

FVT-1 Is a Mammalian 3-Ketodihydrosphingosine Reductase with an Active Site That Faces the Cytosolic Side of the Endoplasmic Reticulum Membrane

Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress

Identification and Characterization of a Novel Human Sphingosine-1-phosphate Phosphohydrolase, hSPP2

Membrane Topology and Essential Amino Acid Residues of Phs1, a 3-Hydroxyacyl-CoA Dehydratase Involved in Very Long-chain Fatty Acid Elongation

Feedback Inactivation of D-Serine Synthesis by NMDA Receptor-Elicited Translocation of Serine Racemase to the Membrane

Lysophosphatidic Acid 2 Receptor-mediated Supramolecular Complex Formation Regulates Its Antiapoptotic Effect

Role of 2-hydroxy acyl-CoA lyase HACL2 in odd-chain fatty acid production via α-oxidation in vivo

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